dc.contributor.author
Saladrigas, Mar
dc.contributor.author
Loren, Guillem
dc.contributor.author
Bonjoch i Sesé, Josep
dc.contributor.author
Bradshaw, Ben
dc.date.issued
2019-02-18T10:21:11Z
dc.date.issued
2019-11-30T06:10:19Z
dc.date.issued
2019-02-18T10:21:11Z
dc.identifier
https://hdl.handle.net/2445/128361
dc.description.abstract
A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C−C bond through a radical process is described. The sequence comprises an initial in situ generation of a putative iron hydride followed by a hydrogen atom transfer to an alkene, a coupling with a hydrazone, and a final reduction of the nitrogen-centered radical. Hydrogenation of the obtained hydrazines renders amines, including valuable tert-alkyl amines. KEYWORDS: HAT, iron catalysis, α-tert-amines, C−C bond formation, radical processes, synthetic methods
dc.format
application/pdf
dc.publisher
American Chemical Society
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1021/acscatal.8b03794
dc.relation
ACS Catalysis, 2018, vol. 8, p. 11699-11703
dc.relation
https://doi.org/10.1021/acscatal.8b03794
dc.rights
(c) American Chemical Society , 2018
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Enllaços químics
dc.subject
Química orgànica
dc.subject
Chemical bonds
dc.subject
Organic chemistry
dc.title
Hydrogen Atom Transfer (HAT)-Triggered Iron-Catalyzed Intra- and Intermolecular Coupling of Alkenes with Hydrazones: Access to Complex Amines
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
