dc.contributor.author
Solé Arjó, Daniel
dc.contributor.author
Mariani, Francesco
dc.contributor.author
Bennasar Fèlix, M. Lluïsa
dc.contributor.author
Fernández Cadenas, Israel
dc.date.issued
2019-01-30T13:51:43Z
dc.date.issued
2019-01-30T13:51:43Z
dc.date.issued
2016-04-15
dc.date.issued
2019-01-30T13:51:43Z
dc.identifier
https://hdl.handle.net/2445/127737
dc.description.abstract
A palladium‐catalyzed carbene insertion into C(sp3)−H bonds leading to pyrrolidines was developed. The coupling reaction can be catalyzed by both Pd0 and PdII, is regioselective, and shows a broad functional group tolerance. This reaction is the first example of palladium‐catalyzed C(sp3)−C(sp3) bond assembly starting from diazocarbonyl compounds. DFT calculations revealed that this direct C(sp3)−H bond functionalization reaction involves an unprecedented concerted metalation-deprotonation step.
dc.format
application/pdf
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1002/anie.201602020
dc.relation
Angewandte Chemie-International Edition, 2016, vol. 55, num. 22, p. 6467-6470
dc.relation
https://doi.org/10.1002/anie.201602020
dc.rights
(c) Wiley-VCH, 2016
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Pal·ladi (Element químic)
dc.subject
Síntesi orgànica
dc.subject
Complexitat computacional
dc.subject
Química organometàl·lica
dc.subject
Organic synthesis
dc.subject
Computational complexity
dc.subject
Organometallic chemistry
dc.title
Palladium-catalyzed intramolecular carbene insertion into C(sp3)-H bonds
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
