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Removal of the chiral inductor from phenylglycinol-derived tricyclic lactams. Unexpected generation of chiral trans-hydrochromene lactones

Author

Griera Farres, Rosa

Pinto, Alexandre

Fabregat, Robert

Cots, Èric

Bosch Cartes, Joan

Amat Tusón, Mercedes

Publication date

2019-01-25T10:06:09Z

2019-12-31T06:10:14Z

2018

2019-01-25T10:06:09Z

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Abstract

In the search for synthetic routes for the preparation of cis- and trans- decahydroquinolin-2- ones, a procedure for the generation of enantiopure trans-hydrochromene lactones, by treatment of (R)- phenylglycinol-derived oxazoloquinolone lactams with Na/liq. NH3 followed by acidification, has been developed.

Document Type

Article

Accepted version

Language

English

Subjects and keywords

Alcaloides; Lactames; Síntesi asimètrica; Alkaloids; Lactams; Asymmetric synthesis

Publisher

Bentham Science Publishers

Related items

Versió postprint del document publicat a: https://doi.org/10.2174/1570178615666171213143657

Letters In Organic Chemistry, 2018, vol. 15, num. 5, p. 335-339

https://doi.org/10.2174/1570178615666171213143657

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Rights

(c) Bentham Science Publishers, 2018

This item appears in the following Collection(s)

Farmacologia, Toxicologia i Química Terapèutica [675]

Institut de Biomedicina (IBUB) [330]

ISGlobal - Institut de Salut Global de Barcelona [60793]