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Preparation and Double Michael Addition Reactions of a Synthetic Equivalent of Nazarov Reagent

Author

Amat Tusón, Mercedes

Arioli, Federica

Pérez Bosch, Maria

Molins i Grau, Elies

Bosch Cartes, Joan

Publication date

2017-03-08T14:29:59Z

2017-03-08T14:29:59Z

2013-04-25

2017-03-08T14:29:59Z

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Abstract

A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base-catalyzed double Michael addition reactions with a,b-unsaturated carbonyl compounds, has been developed. The new reagent satisfactorily reacts with unsaturated indolo[2,3-a]quinolizidine lactams to give pentacyclic yohimbinone-type derivatives.

Document Type

Article

Accepted version

Language

English

Subjects and keywords

Indicadors (Química); Proves i reactius químics; Lactames; Indicators and test-papers; Chemical tests and reagents; Lactams

Publisher

American Chemical Society

Related items

Versió postprint del document publicat a: https://doi.org/10.1021/ol400934c

Organic Letters, 2013, vol. 15, num. 10, p. 2470-2473

https://doi.org/10.1021/ol400934c

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DIDL MARC MARC_CCUC METS OAI_DC ORE QDC RDF

Rights

(c) American Chemical Society , 2013

This item appears in the following Collection(s)

Farmacologia, Toxicologia i Química Terapèutica [675]

ISGlobal - Institut de Salut Global de Barcelona [60808]

Nutrició, Ciències de l'Alimentació i Gastronomia [778]