dc.contributor.author
Amat Tusón, Mercedes
dc.contributor.author
Pinto, Alexandre
dc.contributor.author
Griera Farres, Rosa
dc.contributor.author
Bosch Cartes, Joan
dc.date.issued
2017-03-07T13:11:15Z
dc.date.issued
2017-03-07T13:11:15Z
dc.date.issued
2015-07-21
dc.date.issued
2017-03-07T13:11:15Z
dc.identifier
https://hdl.handle.net/2445/108026
dc.description.abstract
The marine alkaloids (-)-lepadins A-C and (+)-lepadin D, belonging to two diastereoisomeric series, were synthesized from an (R)-phenylglycinol-derived tricyclic lactam via a common cis-decahydroquinoline intermediate. Crucial aspects of the synthesis are the stereochemical control in the assembly of the cis-decahydroquinoline platform, in the introduction of the C2 methyl and C3 hydroxy substituents, and in the generation of the C5 stereocenter.
dc.format
application/pdf
dc.relation
Versió postprint del document publicat a: https://doi.org/10.1002/chem.201501909
dc.relation
Chemistry-A European Journal, 2015, vol. 21, num. 36, p. 12804-12808
dc.relation
https://doi.org/10.1002/chem.201501909
dc.rights
(c) Wiley-VCH, 2015
dc.rights
info:eu-repo/semantics/openAccess
dc.source
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)
dc.subject
Compostos heterocíclics
dc.subject
Síntesi asimètrica
dc.subject
Heterocyclic compounds
dc.subject
Asymmetric synthesis
dc.title
Enantioselective synthesis of lepadins A D from a phenylglycinol-derived hydroquinolone lactam
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/acceptedVersion
