Química Inorgànica i Orgànica: Recent submissions
Now showing items 21-40 of 978
Photoactivation of the cytotoxic properties of platinum(II) complexes through ligand photoswitching
The development of photoactivatable metal complexes with potential anticancer properties is a topical area of current investigation. Photoactivated chemotherapy using coordination compounds is typically based on photochemical ...
Cronologia comentada de la cristal·lografia i la química estructural
Podeu consultar la versió en castellà a: http://hdl.handle.net/2445/120607 i la versió en anglès a: http://hdl.handle.net/2445/120608
Alkylation of oxazolones and related heterocycles through an SN1 reaction.
The alkylation of oxazolones through an SN1 reaction by using stabilized carbocations is reported. The reaction (catalyzed by Brønsted acids, such as TFA or thioureas) affords the final compounds in excellent yields. ...
Cronología comentada de la cristalografía y la química estructural
Podeu consultar la versió en català a: http://hdl.handle.net/2445/116604 i la versió en anglès a: http://hdl.handle.net/2445/120608
Single ion anisotropy and intramolecular interactions in CeIII and NdIII dimers
This article reports the syntheses, characterization, structural description, together with magnetic and spectroscopic properties of two isostructural molecular magnets based on the chiral ligand N,N′-bis((1,2-diphenyl-( ...
Multi-Length Scale Communication Effects in Catalysis: Thinking Big and Acting Small
The use of hierarchically structured materialsas catalysts has been finding increasing applicationin the past years. For these catalytic systems, notonly the nano-scale matters: a high degree of orderacross multiple length ...
Photoswitchable dynasore analogs to control endocytosis with light
The spatiotemporal control of cellular dynamic processes has great fundamental interest but lacks versatile molecular tools. Dynamin is a key protein in endocytosis and an appealing target to manipulate cell trafficking ...
[RuCl2(η6 ‑p‑cymene)(P*)] and [RuCl2(κ-P*‑η6 ‑arene)] Complexes Containing P‑Stereogenic Phosphines. Activity in Transfer Hydrogenation and Interactions with DNA
The preparation of a series of half-sandwich ruthenium complexes, [RuCl2(η6-p-cymene)(P*)] (P* = SPMeRR′) and [RuCl2(κ-P*-η6-arene)], containing P-stereogenic phosphines is reported. The borane-protected Pstereogenic ...
Membrane interaction of polymyxin B and synthetic analogues studied in biomimetic systems: implications for antibacterial action
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/46988
Anti-Amyloid Drug Screening Methods Using Bacterial Inclusion Bodies
Amyloid aggregation is linked to a number of human disorders that range from non-neurological illnesses such as type 2 diabetes to neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. The formation of ...
Fluctuation-dominated kinetics under stirring
We investigate the effects of stirring on the kinetics of the A + B → 0 reaction under stoichiometrical conditions in 2D. We consider both a steady eddy-lattice flow and a random flow mimicking turbulence. In both ...
Synthesis of (E)-4-bromo-3-methoxybut-3-en-2-one, the key fragment in the polyhydroxylated chain common to oscillariolide and phormidolides A-C
The terminal bromomethoxydiene (BMD) moiety of the polyhydroxylated chain present in phormidolides and oscillariolides has been synthesized for first time. Several strategies for the stereoselective synthesis of the ...
Membrane association and contact formation by a synthetic analogue of polymyxin B and its fluorescent derivatives
sP-B is a synthetic analogue of the natural lipopeptide antibiotic polymyxin B (PxB) that maintains the ability of the parent compound to form vesicle-vesicle contacts and induce lipid exchange. Exchange is selective, and ...
The synthesis of 1,2,3,6,6a,7-hexahydro-7-methyl-5-imino-1H-pyrrolo[1,2-c]imidazolo[5,4-b]indole
N-3-(1-Methylindol-3-yl)propan-N-(2,2,2-trichloroethoxysulfonyl)guanidine was synthesized from 3-formyl-1-methylindole in six steps and subjected to conditions intended to convert the side-chain into a 2-iminotetrahydropyrimidine- ...
Diverse coordination numbers and geometries in pyridyl adducts of lanthanide(III) complexes based on beta-diketonate
t: Ten mononuclear rare earth complexes of formula [La(btfa)3 (H2O)2 ] (1), [La(btfa)3 (4,40 - Mt2bipy)] (2), [La(btfa)3 (4,40 -Me2bipy)2 ] (3), [La(btfa)3 (5,50 -Me2bipy)2 ] (4), [La(btfa)3 (terpy)] (5), [La(btfa)3 ...
Synthesis and structure - Activity relationship study of potent cytotoxic analogues of the marine alkaloid Lamellarin D
The marine alkaloid, Lamellarin D (Lam-D), has shown potent cytotoxicity in numerous cancer cell lines, and was recently identified as a potent topoisomerase I inhibitor. A library of open lactone analogs of Lam-D was ...
Probing the Kinetic and Thermodynamic Fingerprints of Anti-EGF Nanobodies by Surface Plasmon Resonance
Despite the widespread use of antibodies in clinical applications, the precise molecular mechanisms underlying antibody-antigen (Ab-Ag) interactions are often poorly understood. In this study, we exploit the technical ...
Chapter One – Larock Reaction in the synthesis of heterocyclic compounds
The indole ring is one of the most common features in natural products and small molecules with important bioactivity. Larock reported a new methodology for the synthesis of the indole ring system based on the palladium-catalyzed ...
Structures of ethylenediaminetetraacetato (3-) metal complexes. I complexes with Co, Mg and Cd metals
(I): Hexaaquacobalt(II) aqua[ethylenediaminetetraacetato(3-)]cobaltate(II) dihydrate, [Co(H2O)6][Co(C10H13N2O8)(H2O)]2.2H2O (Ibis): Hexaaquamagnesium(II) aqua[ethylenediaminetetraacetato(3-)]magnesiate(II) dihydrate, ...
Toward the Synthesis of Phormidolides
A convergent and stereoselective approach for the synthesis of marine natural product (MNP) phormidolide D (PM D) is proposed. Two main disconnections divided PM D in three molecular fragments: the macrocyclic core 4, the ...
