Química Inorgànica i Orgànica: Recent submissions
Now showing items 41-60 of 978
Three to Tango: Inhibitory Effect of Quercetin and Apigenin on Acetylcholinesterase, Amyloid-β Aggregation and Acetylcholinesterase-Amyloid Interaction
One of the pathological hallmarks of Alzheimer's disease (AD) is the formation of amyloid-β plaques. Since acetylcholinesterase (AChE) promotes the formation of such plaques, the inhibition of this enzyme could slow down ...
Synthesis of Cyclopalladated Derivatives of (E)-N2 Benzylidene-2-(2,6-dichlorophenyl)ethanamine and Their Reactivity towards Monodentate andSymmetric Bidentate Lewis Bases
Treatment of the monoimine (E)-N-benzylidene-2-(2,6-dichlorophenyl)ethanamine (1) with a stoichiometric amount of Pd(OAc)(2) in acetic acid at 60 degrees C under nitrogen produced the corresponding acetato-bridged endo ...
Structure vs. excitonic transitions in self-assembled porphyrin nanotubes and their effect on light absorption and scattering
The optical properties of diprotonated meso-tetrakis(4-sulphonatophenyl)porphyrin (TPPS4) J-aggregates of elongated thin particles (nanotubes in solution and ribbons when deposited on solid interfaces) are studied by ...
Intercalative DNA binding of the marine anticancer drug variolin B
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic ...
On the mechano-chiral effect of vortical flows on the dichroic spectra of 5-phenyl-10,15,20-tris(4-sulfonatophenyl)porphyrin J-aggregates
Phase-modulated ellipsometry of the J-aggregates of the title porphyrin shows that the material gives a true CD signal. This confirms that there is a real chiral transfer by mechanical forces, mediated by shear gradient ...
3D Electrophoresis-assisted lithography (3DEAL): 3D molecular printing to create functional patterns and anisotropic hydrogels
The ability to easily generate anisotropic hydrogel environments made from functional molecules with microscale resolution is an exciting possibility for the biomaterials community. This study reports a novel 3D ...
Sudemycin K: a synthetic anti-tumor splicing inhibitor variant with improved activity and versatile chemistry
Important links exist between the process of pre-mRNA splicing and cancer, as illustrated by the frequent mutation of splicing factors in tumors and the emergence of various families of antitumor drugs that target components ...
A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity
Bacterial resistance to almost all available antibiotics is an important public health issue. A major goal in antimicrobial drug discovery is the generation of new chemicals capable of killing pathogens with high selectivity, ...
Synergistic antipseudomonal effects of synthetic peptide AMP38 and carbapenems
The aim was to explore the antimicrobial activity of a synthetic peptide (AMP38) and its synergy with imipenem against imipenem-resistant Pseudomonas aeruginosa. The main mechanism of imipenem resistance is the loss or ...
Snapshot circular dichroism measurements
Two coherent waves carrying orthogonal polarizations do not interfere when they superpose, but an interference pattern is generated when the two waves share a common polarization. This well-known principle of coherence and ...
DNA specificities modulate the binding of human transcription factor A to mitochondrial DNA control region
Human mitochondrial DNA (h-mtDNA) codes for 13 subunits of the oxidative phosphorylation pathway, the essential route that produces ATP. H-mtDNA transcription and replication depends on the transcription factor TFAM, which ...
Iron carbide or iron carbide/cobalt nanoparticles for magnetically-induced CO2 hydrogenation over Ni/SiRAlOx catalysts
Magnetic nanoparticles have recently been used as heating agents in heterogeneously catalyzed reactions such as CO2 hydrogenation into methane. In the present work, we explore the potential of heating agents presenting ...
MiniAp-4: A Venom-Inspired Peptidomimetic for Brain Delivery
Drug delivery across the blood-brain barrier (BBB) is a formidable challenge for therapies targeting the central nervous system. Although BBB shuttle peptides enhance transport into the brain non-invasively, their application ...
Rational design of lanthanoid single-ion magnets: predictive power of the theoretical models
We report two new single-ion magnets (SIMs) of a family of oxydiacetate lanthanide complexes with D-3 symmetry to test the predictive capabilities of complete active space ab initio methods (CASSCF and CASPT2) and the ...
Electronic and steric control of the spin-crossover behavior in [(Cp-R)(2)Mn] manganocenes
A computational study of the spin-crossover behavior in the family [(Cp-R)(2)Mn] (R = Me, Pr-i, Bu-t) is presented. Using the OPBE functional, the different electronic and steric effects over the metal's ligand field are ...
Design and optimization of oestrogen receptor PROTACs based on 4-hydroxytamoxifen
In the last four decades, treatment of oestrogen receptor positive (ER+) breast cancer (BCa), has focused on targeting the estrogenic receptor signaling pathway. This signaling function is pivotal to sustain cell proliferation. ...
Substrate-controlled Michael additions of titanium enolates from chiral α-benzyloxy ketones to conjugated nitroalkenes
Lewis acid-mediated substrate-controlled reactions of the titanium(IV) enolates of chiral a-benzyloxy ketones with conjugated nitroalkenes give the 2,4-anti-4,5-syn Michael adducts in good yields and diastereomeric ratios. ...
Effect of solvent polarity on the spectroscopic properties of an alkynyl gold(I) gelator. The particular case of water
The spectroscopic properties of aggregates obtained from the hydrogelator [Au(4-pyridylethynyl)(PTA)] were studied in solvents of different polarities. Inspection of the absorption and emission spectra of diluted solutions ...
An innovative and environmentally friendly bioorganic synthesis of activated carbon based on olive stones and its potential application for CO2 capture
This work presents an innovative, fully environmentally friendly method of obtaining bioorganic activated carbon based on olive stones by applying banana plant extract as an activating agent. The activated carbon prepared ...
A supramolecular helicate with two independent Fe(ii) switchable centres and a [Fe(anilate)3]3− guest
A biphenyl-spaced bis-pyrazolylpyridine ligand interacts with ferrous ions to engender a dimetallic helical coordination cage that encapsulates an Fe3+ tris-anilate complex. The host–guest interaction breaks the symmetry ...
