Patologia i Terapèutica Experimental: Recent submissions
Now showing items 181-200 of 1057
Percutaneous, intra-articular, Chevron osteotomy (PeICO) for the treatment of hallux valgus: a cadaveric study
Background: Percutaneous surgery is experiencing sustained growth based on third-generation techniques. This cadaveric study was designed with the main goal of exploring the risk of iatrogenic tendon and neurovascular ...
Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer
Adenosine A2A receptor (A2AR)-dopamine D2 receptor (D2R) heteromers are key modulators of striatal neuronal function. It has been suggested that the psychostimulant effects of caffeine depend on its ability to block an ...
Macrophages require distinct arginine catabolism and transport systems for proliferation and for activation.
In murine macrophages, as a result of arginine catabolism during activation, citruline isproduced under the effect of IFN-c and LPS, and ornithine and polyamines by IL-4 and IL-10. For proliferation, arginine is required ...
Telomere length shows no association with BRCA1 and BRCA2 mutation status
This study aimed to determine whether telomere length (TL) is a marker of cancer risk or genetic status amongst two cohorts of BRCA1 and BRCA2 mutation carriers and controls. The first group was a prospective set of 665 ...
Expressió gènica en models d'isquèmia cerebral
La isquèmia cerebral pot causar una lesió irreversible al cervell, amb una important pèrdua neuronal a les zones afectades. Entre els primers canvis que es detecten després de la isquèmia hi ha alteracions del patró ...
Fármacos que inhiben el factor de necrosis tumoral α y embarazo
Pregunta: ?Es segura la administración de los fármacos que inhiben el factor de necrosis tumoral a (TNF-a) durante el embarazo? Respuesta: En los últimos años se han desarrollado medicamentos que inhiben el TNF-a, porque ...
Señalización celular en el hipocampo epiléptico
La señalización celular que manda sobre la muerte o la supervivencia en el hipocampo epiléptico humano es difícil de identificar a causa del prolongado intervalo entre el comienzo de los síntomas y el muestreo del tejido ...
Generation of induced pluripotent stem cells from human cord blood using OCT4 and SOX2
Mouse and human fibroblasts were the first cell types successfully reprog- rammed by ectopic expression of OCT4, SOX2, KLF4, and c-MYC (OSKM) (Lowry et al., 2008; Maherali et al., 2007; Park et al., 2008; Takahashi et al., ...
miR-424(322)/503 is a breast cancer tumor suppressor whose loss promotes resistance to chemotherapy
The female mammary gland is a very dynamic organ that undergoes continuous tissue remodeling during adulthood. Although it is well established that the number of menstrual cycles and pregnancy (in this case transiently) ...
αE-catenin-dependent mechanotransduction is essential for proper convergent extension in zebrafish
Cadherin complexes mediate cell-cell adhesion and are crucial for embryonic development. Besides their structural function, cadherin complexes also transduce tension across the junction-actomyosin axis into proportional ...
Differential expression of genes mapping to recurrently abnormal chromosomal regions characterize neuroblastic tumours with distinct ploidy status
Background: Neuroblastic tumours (NBTs) represent a heterogeneous spectrum of neoplastic diseases associated with multiple genetic alterations. Structural and numerical chromosomal changes are frequent and are predictive ...
Liberación de noradrenalina por reserpina II. Interacción con bretilio en conducto deferente de rata
Desde hace ya algunos años estudiamos en nuestro Departamento la interacción de la reserpina con distintas sustancias que actúan en la presinapsis adrenérgica (simpaticomiméticos indirectos, inhibidores de la MAO, etc.). ...
Multisite Assessment of Aging-Related Tau Astrogliopathy (ARTAG)
Aging-related tau astrogliopathy (ARTAG) is a recently introduced terminology. To facilitate the consistent identification of ARTAG and to distinguish it from astroglial tau pathologies observed in the primary frontotemporal ...
Potential of adipose-derived stem cells in muscular regenerative therapies
Regenerative capacity of skeletal muscles resides in satellite cells, a self-renewing population of muscle cells. Several studies are investigating epigenetic mechanisms that control myogenic proliferation and differentiation ...
Inhibition of the autocrine IL-6-JAK2-STAT3-calprotectin axis as targeted therapy for HR-/HER2+ breast cancers
HER2-positive (HER2(+)) breast adenocarcinomas are a heterogeneous group in which hormone receptor (HR) status influences therapeutic decisions and patient outcome. By combining genome-wide RNAi screens with regulatory ...
TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death
Newborn mice carrying targeted mutations in genes encoding neurotrophins or their signaling Trk receptors display severe neuronal deficits in the peripheral nervous system but not in the CNS. In this study, we show that ...
Estudio embriológico facial: concepto actual
Se presenta el estudio del desarrollo embriológico facial utilizando 10 embriones humanos cuyas edades oscilaban entre los 24 dlas (3 mm) y los 50 días (50 mm). Se valoró la evolución de los procesos naso-medial y naso-lateral ...
The curcumin analog DM-1 induces apoptotic cell death in melanoma
The main difficulty in the successful treatment of metastatic melanoma is that this type of cancer is known to be resistant to chemotherapy. Chemotherapy remains the treatment of choice, and dacarbazine (DTIC) is the best ...
Parkinson's disease DJ-1 L166P alters rRNA biogenesis by exclusion of TTRAP from the nucleolus and sequestration into cytoplasmic aggregates via TRAF6
Mutations in PARK7/DJ-1 gene are associated to autosomal recessive early onset forms of Parkinson"s disease (PD). Although large gene deletions have been linked to a loss-of-function phenotype, the pathogenic mechanism of ...
Prevalence of chronic pain syndrome in patients who have undergone hallux valgus percutaneous surgery: a comparison of sciatic-femoral and ankle regional ultrasound-guided nerve blocks
Background: Chronic pain syndrome (CPS) is a common complication after operative procedures, and only a few studies have focused on the evaluation of CPS in foot-forefoot surgery and specifcally on HV percutaneous correc‑ ...
