Patologia i Terapèutica Experimental: Envíos recientes
Mostrando ítems 321-340 de 1057
Cellular redox systems impact the aggregation of CU,Zn Superoxide Dismutase linked to familial Amyotrophic Lateral Sclerosis
Protein misfolding is implicated in neurodegenerative diseases such as ALS, where mutations of superoxide dismutase 1 (SOD1) account for about 20% of the inherited mutations. Human SOD1 (hSOD1) contains four cysteines, ...
Anatomy of the ankle ligaments: a pictorial essay
Understanding the anatomy of the ankle ligaments is important for correct diagnosis and treatment. Ankle ligament injury is the most frequent cause of acute ankle pain. Chronic ankle pain often finds its cause in laxity ...
SK2 Channels Associate With mGlu1α Receptors and CaV2.1 Channels in Purkinje Cells
The small-conductance, Ca2+-activated K+ (SK) channel subtype SK2 regulates the spike rate and firing frequency, as well as Ca2+ transients in Purkinje cells (PCs). To understand the molecular basis by which SK2 channels ...
The effect of food on tramadol and celecoxib bioavailability following oral administration of Co-Crystal of Tramadol-Celecoxib (CTC): a randomised, open label, single-dose, crossover study in healthy volunteers
ackground and Objective Co-Crystal of Tramadol-Celecoxib (CTC), in development for the treatment of moderate to severe acute pain, is a first-in-class co-crystal containing a 1:1 molecular ratio of two active pharmaceutical ...
The tumour suppressor and chromatin-remodelling factor BRG1 antagonizes Myc activity and promotes cell differentiation in human cancer
BRG1, a member of the SWI/SNF complex, is mutated in cancer, but it is unclear how it promotes tumourigenesis. We report that re-expression of BRG1 in lung cancer cells up-regulates lung-specific transcripts, restoring the ...
Inflammatory Gene Expression In Whole Peripheral Blood At Early Stage Of Sporadic Amyotrophic Lateral Sclerosis
Objective: Characterization of altered expression of selected transcripts linked to inflammation in the peripheral blood of sporadic amyotrophic lateral sclerosis (sALS) patients at early stage of disease to increase ...
Fluoquinolone resistance in Streptococcus pneumoniae
To the Editor: Chen et al. (July 22 issue) report an increasing prevalence of Streptococcus pneumoniae strains with reduced susceptibility to fluoroquinolones in Canada. We have found similar results in Barcelona, Spain.Of ...
Double deficiency of Trex2 and DNase1L2 nucleases leads to accumulation of DNA in lingual cornifying keratinocytes without activating inflammatory responses
The cornification of keratinocytes on the surface of skin and oral epithelia is associated with the degradation of nuclear DNA. The endonuclease DNase1L2 and the exonuclease Trex2 are expressed specifically in cornifying ...
Inappropriate prescribing to older patients admitted to hospital: A comparison of different tools of misprescribing and underprescribing
Purpose: This study aims to assess inappropriate prescribing (IP) to elderly patients during the month prior to hospitalization and to compare different IP criteria. Methods: An observational, prospective and multicentric ...
Effects of increased iron intake during the neonatal period on the brain of adult AβPP/PS1 transgenic mice
The present study was aimed to investigate neuropathological changes in AβPP/PS1 transgenic mice (Tg), as a model of Alzheimer's disease, subjected to supplementary iron administration in a critical postnatal period, in ...
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ...
Coneixements d'anatomia i patologia dels estudiants de 4t curs d'Odontologia
Podeu consultar la Vuitena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/66524
Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer
There is evidence for strong functional antagonistic interactions between adenosine A2A receptors (A2ARs) and dopamine D2 receptors (D2Rs). Although a close physical interaction between both receptors has recently been ...
The guanine-based purinergic system: the tale of an orphan neuromodulation
Guanine-based purines (GBPs) have been recently proposed to be not only metabolic agents but also extracellular signaling molecules that regulate important functions in the central nervous system. In such way, GBPs-mediated ...
Molecular characterization of Streptococcus pneumoniae invasive serotype 19A isolates from adults in two Spanish regions (1994-2009)
From 1994 to 2009, the incidence of invasive serotype 19A pneumococci isolated from adults in Barcelona and San Sebastian almost doubled every 4 years. Genotyping of the 167 invasive isolates studied showed serotype 19A ...
Relevance of digestive tract colonization in the epidemiology of nosocomial infections due to multiresistant Acinetobacter baumanii
Fecal colonization with multiresistant Acinetobacter baumannii was evaluated in 189 consecutive patients in intensive care units (ICUs) during two different 2-month periods (October-November 1993 and May-June 1994). Rectal ...
Desviación forzada de la mirada hacia abajo y adentro en un caso de hemorragia de la región periacueductal
Se describe un caso de una paciente con un síndrome incompleto de Koerber-Elschnig, compuesto por imposibilidad de la mirada hacia arriba permaneciendo los ojos hacia abajo y adentro, nistagmus retractor y de convergencia ...
Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1
Excitotoxicity, a critical process in neurodegeneration, induces oxidative stress and neuronal death through mechanisms largely unknown. Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated ...
Prostate tumor overexpressed-1 (PTOV1) promotes docetaxel- resistance and survival of castration resistant prostate cancer cells
Metastatic prostate cancer is presently incurable. The oncogenic protein PTOV1, first described in prostate cancer, was reported as overexpressed and significantly correlated with poor survival in numerous tumors. Here, ...
Role of Serum Cholesterol and Statin Use in the Risk of Prostate Cancer Detection and Tumor Aggressiveness
The aim of this study was to analyze the relationship between statin use along with serum cholesterol levels and prostate cancer (PCa) detection and aggressiveness. Statin users of three years or more and serum cholesterol ...
