Patologia i Terapèutica Experimental: Recent submissions
Now showing items 401-420 of 1057
Transport de nucleòsids
La presència de transportadors específics per a nucleòsids ha estat descrita en nombrosos tipus cel·lulars. Els factors que justifiquen l'existencia d'aquests transportadors son diversos..
YKL40 in sporadic amyotrophic lateral sclerosis: cerebrospinal fluid levels as a prognosis marker of disease progression
Abstract Amyotrophic lateral sclerosis (ALS) has variable clinical course and fatal outcome. Since inflammation plays a role in the pathogenesis of ALS, chitinase-3-like protein 1 or YKL40 has been assessed as putative ...
The loss of c-Jun N-Terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo
Phosphorylation plays a central role in the dynamic regulation of the processing of the amyloid precursor protein (APP) and the production of amyloid-β (Aβ), one of the clinically most important factors that determine the ...
Neurokinin receptors differentially mediate endogenous acetylcholine release evoked by tachykinins in the neostriatum.
The regulation of neostriatal cholinergic function by tachykinins (TKs) has been studied by measuring endogenous ACh released from rat neostriatal slices. Septide (SEP; a highly selective substance P analog), neurokinin A ...
Peutz-Jeghers syndrome: a systematic review and recommendations for management
Peutz¿Jeghers syndrome (PJS, MIM175200) is an autosomal dominant condition defined by the development of characteristic polyps throughout the gastrointestinal tract and mucocutaneous pigmentation. The majority of patients ...
Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of ...
Incidence of Recurrent High-Grade Anal Dysplasia in HIV-1-Infected Men and Women Following Infrared Coagulation Ablation: A Retrospective Cohort Study
This single-center, retrospective cohort study sought to estimate the cumulative incidence in HIV-1-infected patients of biopsy-proven high-grade anal intraepithelial neoplasia (HGAIN) recurrence after infrared coagulation ...
Generalized muscle pseudo-hypertrophy and stiffness associated with the myotilin Ser55Phe mutation: a novel myotilinopathy phenotype?
Myotilinopathies are a group of muscle disorders caused by mutations in the MYOT gene. It was first described in two families suffering from limb girdle muscle dystrophy type 1 (LGMD 1A), and later identified in a subset ...
Functional and Structural Analysis of C-Terminal BRCA1 Missense Variants
Germline inactivating mutations in BRCA1 and BRCA2 genes are responsible for Hereditary Breast and Ovarian Cancer Syndrome (HBOCS). Genetic testing of these genes is available, although approximately 15% of tests identify ...
Evaluation of Potential Pain Biomarkers in Saliva and Pain Perception After Corneal Advanced Surface Ablation Surgery
Purpose: To evaluate the evolution of a set of proposed pain biomarkers in the saliva of subjects following Advanced Surface Ablation (ASA), in order to determine their validity as objective pain measures. Methods: A ...
Glutamate Transporter Glt1 Expression In Alzheimer Disease And Dementia With Lewy Bodies
Glutamate transporter solute carrier family 1, member 2 (GLT1/EAAT2), a major modulator of glutamate homeostasis in astrocytes, is assessed in post-mortem human brain samples of frontal cortex area 8 in advanced stages of ...
The role of Serratia marcescens porins in antibiotic resistance
The outer membrane permeability of Serratia marcescens was studied by comparing porin-deficient mutants with their parental strains. Omp1-deficient strains were selected by moxalactam resistance, whereas mutants lacking ...
Nuclear localization and phosphorylation modulate pathological effects of α-synuclein
Alpha-synuclein (aSyn) is a central player in Parkinson's disease (PD) but the precise molecular mechanisms underlying its pathogenicity remain unclear. It has recently been suggested that nuclear aSyn may modulate gene ...
Disease-specific phenotypes in dopamine neurons from human iPS-based models of genetic and sporadic Parkinson's disease
Induced pluripotent stem cells (iPSC) offer an unprecedented opportunity to model human disease in relevant cell types, but it is unclear whether they could successfully model age-related diseases such as Parkinson's disease ...
Multiple low dose therapy as an effective strategy to treat EGFR inhibitor-resistant NSCLC tumours
Resistance to targeted cancer drugs is thought to result from selective pressure exerted by a high drug dose. Partial inhibition of multiple components in the same oncogenic signalling pathway may add up to complete pathway ...
Mandible measurements and dental midline deviation after alveolar nerve transection in growing rabbits
Summary: the relationship between sensitive innervation and normal mandibular bone development has been described in the literature. Therefore, neural damage is a potential cause of osseous deformities, particularly in ...
Generation of neurons from somatic cells of healthy individuals and neurological patients through induced pluripotency or direct conversion
Access to healthy or diseased human neural tissue is a daunting task and represents a barrierfor advancing our understanding about the cellular, genetic, and molecular mechanisms underly-ing neurogenesis and neurodegeneration. ...
Oligomerización de receptores acoplados a proteína G y enfermedad de Parkinson
La enfermedad de Parkinson es una condición neurodegenerativa del sistema nervioso central que puede aparecer en la madurez pero cuya incidencia aumenta dramáticamente en la tercera edad. Por este motivo, en las sociedades ...
Special issue: adenosine receptors
Nearly 90 years ago, Drury and Szent-Györgyi revealed that adenosine produced profound hypotension and bradycardia, and it affected kidney function in mammals [1]. Since then, the physiological role and potential therapeutic ...
Tumor xenograft modeling identifies an association between TCF4 loss and breast cancer chemoresistance
Understanding the mechanisms of cancer therapeutic resistance is fundamental to improving cancer care. There is clear benefit from chemotherapy in different breast cancer settings; however, knowledge of the mutations and ...
