Patologia i Terapèutica Experimental: Enviaments recents
Ara mostrant els elements 421-440 de 1057
Familial Alzheimer's disease-associated presenilin-1 alters cerebellar activity and calcium homeostasis
Familial Alzheimer's disease (FAD) is characterized by autosomal dominant heritability and early disease onset. Mutations in the gene encoding presenilin-1 (PS1) are found in approximately 80% of cases of FAD, with some ...
Functional stability and community dynamics during spring and autumn seasons over 3 years in Camargue microbial mats
Microbial mats are complex biofilms in which the major element cycles are represented at a millimeter scale. In this study, community variability within microbial mats from the Camargue wetlands (Rhone Delta, southern ...
Epsilon toxin from clostridium perfringens induces the generation of extracellular vesicles in HeLa cells overexpressing myelin and lymphocyte protein
Epsilon toxin (ETX) from Clostridium perfringens is a pore-forming toxin (PFT) that crosses the blood-brain barrier and binds to myelin structures. In in vitro assays, ETX causes oligodendrocyte impairment, subsequently ...
FOXP2 expression in frontotemporal lobar degeneration-tau
FOXP2 is altered in a variety of language disorders. We found reduced mRNA and protein expression of FOXP2 in frontal cortex area 8 in Pick's disease, and frontotemporal lobar degeneration-tau linked to P301L mutation ...
SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer's disease
Dysfunctional RNA-binding proteins (RBPs) have been implicated in several neurodegenerative disorders. Recently, this paradigm of RBPs has been extended to pathophysiology of Alzheimer's disease (AD). Here, we identified ...
Nontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates.
Non-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the ...
Effectiveness of physically ablative (electrosurgery excision, infrared coagulation) and pharmacological treatments (imiquimod) for anal canal condylomata in HIV-infected men
Background: There is limited information on the effectiveness of available treatments for anal condyloma acuminata in HIV-1-infected men. Aim: To provide data on the effectiveness of electrosurgical excision, infrared ...
Kidins220 correlates with tau in Alzheimer's disease brain and cerebrospinal fluid
Identification of neurodegeneration-monitoring biomarkers would be of great clinical value for Alzheimer's disease (AD) diagnosis. Using N- or C-terminal antibodies, we studied the pro-survival synaptic effector, Kidins220, ...
Genetic association study of coronary collateral circulation in patients with coronary artery disease using 22 single nucleotide polymorphisms corresponding to 10 genes involved in postischemic neovascularization
Background: collateral growth in patients with coronary artery disease (CAD) is highly heterogeneous. Although multiple factors are thought to play a role in collateral development, the contribution of genetic factors to ...
Retrieval of germinal zone neural stem cells from the cerebrospinal fluid of premature infants with intraventricular hemorrhage
Intraventricular hemorrhage is a common cause of morbidity and mortality in premature infants. The rupture of the germinal zone into the ventricles entails loss of neural stem cells and disturbs the normal cytoarchitecture ...
Coexistence of protease sensitive and resistant prion protein in 129VV homozygous sporadic Creutzfeldt-Jakob disease: a case report
Introduction: The coexistence of different molecular types of classical protease-resistant prion protein in the same individual have been described, however, the simultaneous finding of these with the recently described ...
Changes in fluoroquinolone-resistant Streptococcus pneumoniae after 7-valent conjugate vaccination, Spain
Among 4,215 Streptococcus pneumoniae isolates obtained in Spain during 2006, 98 (2.3%) were ciprofloxacin resistant (3.6% from adults and 0.14% from children). In comparison with findings from a 2002 study, global resistance ...
Impact of antibiotic resistance on chemotherapy for pneumococcal infections
Over the past three decades, penicillin-resistant pneumococci have emerged worldwide. In addition, penicillin-resistant strains have also decreased susceptibility to other β-lactams (including cephalosporins) and these ...
Burden of Human Papillomavirus (HPV)-Related Cancers Attributable to HPVs 6/11/16/18/31/33/45/52 and 58
Background: Many countries, mainly high- and upper-middle income, have implemented human papillomavirus (HPV) vacci- nation programs, with 47 million women receiving the full course of vaccine (three doses) in 2014. To ...
Proteome-wide characterization of signalling interactions in the hippocampal CA4/DG subfield of patients with Alzheimer’s disease
Alzheimer's disease (AD) is the most common form of dementia; however, mechanisms and biomarkers remain unclear. Here, we examined hippocampal CA4 and dentate gyrus subfields, which are less studied in the context of AD ...
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer’s disease progression
Olfactory dysfunction is among the earliest features of Alzheimer's disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, ...
Cannabinoid receptor 2 participates in amyloid-β processing in a mouse model of alzheimer's disease but plays a minor role in the therapeutic properties of a cannabis based medicine
The endogenous cannabinoid system represents a promising therapeutic target to modify neurodegenerative pathways linked to Alzheimer's disease (AD). The aim of the present study was to evaluate the specific contribution ...
Succination of protein thiols in human brain aging
Human brain evolution toward complexity has been achieved with increasing energy supply as the main adaptation in brain metabolism. Energy metabolism, like other biochemical reactions in aerobic cells, is under enzymatic ...
Using prodigiosin against some gram-positive and gram-negative bacteria and Trypanosoma cruzi
BACKGROUND: This work aimed to explore the action of natural prodigiosin on both bacterial organisms and Trypanosoma cruzi cells. METHODS: Natural prodigiosin pigment was extracted and purified from cultures of Serratia ...
Effect of ascitic liquid on growth in vitro of embryoid bodies derived from teratocarcinoma
Embryoid bodies (EB) derived from teratocarcinoma (TC)OTT6050 were cultured with ascitic liquids (AL) from animals carrying 16-, 22- and 35-day evolved EB. At the same time the presence of fibronectin (FN) in AL were ...
