Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.  

Pardo Muñoz, Mónica; Gregorio Jordán, Sara; Montalban, Enrica; Pujadas Puigdomènech, Lluís; Elias-Tersa, Alba; Vílchez Acosta, Alba del Valle; Parent, Annabelle; Auladell i Costa, M.Carme; Girault, Jean-Antoine; Vila, Miquel; Angus, C. Nairn; Manso Sanz, Yasmina; Soriano Garcia, Eduardo (Publication date: 2026-03-10)

In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, ...

Human microglia-like cells differentiated from monocytes with GM-CSF and IL-34 show phagocytosis of α-synuclein aggregates and C/EBPβ-dependent proinflammatory activation 

Llaves López, Andrea; Micoli, Elia; Belmonte Mateos, Carla; Aguilar, Gerard; Alba, Clara; Marsal, Anais; Pulido Salgado, Marta; Rabaneda Lombarte, Neus; Solà i Subirana, Carme; Serratosa i Serdà, Joan; Vidal Taboada, José Manuel; Saura Martí, Josep (Publication date: 2026-02-12)

Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using rodent microglial ...

Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease 

Barranco Muñoz, Neus; Plá, Virginia; Alcolea, Daniel; Sánchez Domínguez, Irene; Fischer-Colbrie, Reiner; Ferrer, Isidro (Ferrer Abizanda); Lleó Bisa, Alberto; Aguado Tomàs, Fernando (Publication date: 2026-02-02)

Background: New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising ...

Long-lasting behavioral, molecular and functional connectivity alterations after chronic THC exposure during adolescence in mice 

Gómez Acero, Laura; Varriano, Federico; Sánchez Fernández, Nuria; Ciruela Alférez, Francisco; Soria, Guadalupe; Aso Pérez, Ester (Publication date: 2025-07-18)

Heavy and daily use of cannabis with high contents of Delta 9-tetrahydrocannabinol (THC) during adolescence is associated with an increased risk of developing psychotic disorders later in life. Here, we treated mice with ...

The PADRIS-PRESTO Cohort: A Comprehensive Population-Based Study on Mental Health in Catalonia 

De Prisco, Michele; Oliva, Vincenzo; Fico, Giovanna; Mas, Ariadna; Valenzuela-Pascual, Clàudia; Montejo Egido, Laura; Bort, Marta; Sommerhof, Constanza; Bortolozzi, Analia; Miquel Rio, Lluís; Vilella, Elisabet; Forte, Maria Florencia; Fortea, Lydia; Fernández-Plaza, Tábatha; Giménez Palomo, Anna; Sagué-Vilavella, Maria; Madero Gómez, Santiago; Llorca-Bofí, Vicent; Bioque Alcázar, Miquel; Grande i Fullana, Iria; Murru, Andrea; Pacchiarotti, Isabella; Cavero Álvarez, Myriam; Blanch Andreu, Jordi; Viñas-Bardolet, Clara; Aparicio-Nogué, Vicenç; Martínez-Cerdá, Juan Francisco; Parellada Rodón, Eduard; Martínez-Arán, Anabel, 1971-; Radua, Joaquim; Vieta i Pascual, Eduard, 1963-; Hidalgo Mazzei, Diego; Anmella, Gerard (Publication date: 2025-11-10)

Background: Mental disorders affect nearly 970 million people worldwide, impacting individuals and healthcare systems. Large population databases offer insights often unattainable in smaller studies, but their findings may ...

Body ownership increases the interference between observed and executed movements 

Burin, Dalila; Kilteni, Konstantina; Rabuffetti, Marco; Slater, Mel; Pia, Lorenzo (Publication date: 2021-03-22)

When we successfully achieve willed actions, the feeling that our moving body parts belong to the self (i.e., body ownership) is barely required. However, how and to what extent the awareness of our own body contributes ...

Validation of the English version of the Mood Rhythm Instrument 

Oliveira, Melissa A. B.; Epifano, Kristina; Mathur, Salina; Gutiérrez Carvalho, Felipe; Scop, Marina; Carissimi, Alicia; Francisco, Ana Paula; Garay, Luciene L. S.; Adan Puig, Ana; Hidalgo, Maria Paz; Frey, Benicio N. (Publication date: 2021-05-11)

Background: Disruption of biological rhythms has been linked to the pathophysiology of mental disorders. However, little is known regarding the rhythmicity of mood symptoms due to the lack of validated clinical questionnaires. ...

Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood 

Prats Soteras, Xavier; Jurado, Ma. Ángeles (María Ángeles); Ottino González, Jonatan; García-García, Isabel; Segura i Fàbregas, Bàrbara; Caldú i Ferrús, Xavier; Sánchez-Garre, Consuelo; Miró, Núria; Tor, C.; Sender Palacios, María José; Garolera i Freixa, Maite (Publication date: 2020-06-08)

Background/objectives Excessive body mass index (BMI) has been linked to a low-grade chronic inflammation state. Unhealthy BMI has also been related to neuroanatomical changes in adults. Research in adolescents is relatively ...

Mismach between perceived family and individual chronotype and their association with sleep-wake patterns 

Pereira Morales, Angela J.; Adan Puig, Ana; Casiraghi, Leandro P.; Camargo, Andrés (Publication date: 2021-04-28)

While social zeitgebers are known to shape diurnal preference, little research has been devoted to determining the contribution of the familiar group chronotype as social zeitgeber on individual circadian rhythms and ...

Effects and Mechanisms of Cognitive, Aerobic Exercise, and Combined Training on Cognition, Health, and Brain Outcomes in Physically Inactive Older Adults: The Projecte Moviment Protocol 

Castells Sánchez, Alba; Roig-Coll, Francesca; Lamonja-Vicente, Noemí; Altés Magret, Marina; Torán Monserrat, Pere; Via i García, Marc; García Molina, Alberto; Tormos, José María; Heras, Antonio; Alzamora, María Teresa; Forés, Rosa; Pera, Guillem; Dacosta-Aguayo, Rosalia; Soriano Raya, Juan José; Cáceres, Cynthia; Montero Alía, Pilar; Montero Alia, Juan José; Jiménez González, María Mercedes; Hernández Pérez, María; Perera Lluna, Alexandre; Grove, George A.; Munuera, Josep; Domènech, Sira; Erickson, Kirk I.; Mataró Serrat, Maria (Publication date: 2021-03-24)

Introduction: Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and ...

One year follow-up of a randomized trial with a dilema-focused intervention for depression: Exploring an alternative to problem-oriented strategies 

Feixas i Viaplana, Guillem; Paz, Clara; García Grau, Eugeni; Montesano del Campo, Adrián; Medina Alcaraz, Juan Carlos; Bados López, Arturo; Trujillo, Adriana; Ortiz Garzón, Eliana; Compañ, Victoria; Salla Martínez, Marta; Aguilera, Marta; Guasch, Victor; Codina, Jordi; Winter, David A., 1950- (Publication date: 2019-03-18)

Background Cognitive behavioural therapy (CBT) is aimed to counteract cognitions and behaviours that are considered as dysfunctional. The aim of the study is to test whether the inclusion of a non-counteractive approach ...

Reducing risk and improving maternal perspective-taking and empathy using virtual embodiment 

Hamilton-Giachritsis, Catherine; Banakou, Domna; García Quiroga, Manuela; Giachritsis, Christos; Slater, Mel (Publication date: 2018-11-07)

The ability to perspective-take (cognitive awareness of another's state) and empathise (emotional/affective response) are important characteristics for sensitive, co-operative and constructive parenting, which assists in ...

RNA editing-based biomarker blood test for the diagnosis of bipolar disorder: protocol of the EDIT-B study 

Miranda-Mendizabal, Andrea; Vetter, Diana; Zambrano, Juan; Zarp, Jeff; Chavarría Romero, Víctor; Giménez Palomo, Anna; Gonzalez Campos, Meritxell; Valentí Ribas, Marc; Walczer Baldinazzo, Lara; Siddi, Sara; Ferrari, Maurizio; Weissmann, Dinah; Henry, Chantal; Haro Abad, Josep Maria; Vedel Kessing, Lars; Vieta i Pascual, Eduard, 1963- (Publication date: 2025-03-25)

Introduction: Misdiagnosis of bipolar disorder (BD) can lead to ineffective treatment, increased risk of manic episodes, and increased severity. Objective diagnostic tests or precise tools to diagnose BD and distinguish ...

Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium 

Fjell, Anders Martin; Sørensen, Øystein; Amlien, Inge K.; Bartrés Faz, David; Macià Bros, Dídac; Buchmann, Nikolaus; Demuth, Ilja; Drevon, Christian A; Düzel, Sandra; Ebmeier, Klaus P.; Idland, Ane-Victoria; Kietzmann, Tim C.; Kievit, Rogier; Kühn, Simone; Lindenberger, Ulman; Mowinckel, Athanasia Monika; Nyberg, Lars; Price, Darren; Sexton, Claire E.; Solé Padullés, Cristina; Pudas, Sara; Sederevicius, Donatas; Suri, Sana; Wagner, Gerd; Watne, Leiv Otto; Westerhausen, René; Zsoldos, Enikő; Walhovd, Kristine B. (Publication date: 2021-05-03)

Objectives: Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal ...

Executive functions, Personality traits and ADHD symptoms in adolescents: A mediation analysis 

Krieger, Virginia; Amador, Juan Antonio; Guàrdia-Olmos, Joan, 1958- (Publication date: 2020-09-03)

Certain personality traits and cognitive domains of executive functions (EF) are differentially related to attention deficit hyperactivity disorder (ADHD) symptoms in adolescents. This study aimed to analyze the five-factor ...

Assessing motivational stages and processes of change for weight management around bariatric surgery: A multicenter study 

Lecube, Albert; Sánchez, Enric; Andrés, Ana; Saldaña García, Carmina; Morales, María José; Calañas, Alfonso; Miñambres, Inka; Pellitero, Silvia; Cordido, Fernando; Bueno, Marta; Caixàs i Pedragós, Assumpta; Vilarrasa, Nuria; Obesity Group of the Spanish Society of Endocrinology and Nutrition (GOSEEN) (Publication date: 2020-04-03)

Introduction/Purpose: The assessment of the patients' motivation as a predictor of behavioral change via five stages (pre- contemplation, contemplation, preparation, action, and maintenance) and four processes (emotional ...

'Marcadores' emocionales de respuestas (des)adaptativas en cáncer 

Fusté Escolano, Adela; Estapé, T.; Ruiz Rodríguez, José; Estapé, J. (Publication date: 2024-06-12)

Neural signatures of memory gain through active exploration in an oculomotor-auditory learning task 

Sturm, Stefanie; Costa Faidella, Jordi; San Miguel Insua, Iria (Publication date: 2025-05-06)

Active engagement improves learning and memory, and self- versus externally generated stimuli are processed differently: perceptual intensity and neural responses are attenuated. Whether the attenuation is linked to memory ...

Patients' adherence to smartphone apps in the management of bipolar disorder: a systematic review 

Patoz, Marie Camille; Hidalgo Mazzei, Diego; Pereira, Bruno; Blanc, Olivier; Chazeron, Ingrid de; Murru, Andrea; Verdolini, Norma; Pacchiarotti, Isabella; Vieta i Pascual, Eduard, 1963-; Llorca, Pierre Michel; Samalin, Ludovic (Publication date: 2022-03-14)

Background: Despite an increasing number of available mental health apps in the bipolar disorder field, these tools remain scarcely implemented in everyday practice and are quickly discontinued by patients after downloading. ...

Allostatic load and disordered white matter microstructure in overweight adults 

Ottino González, Jonatan; Jurado, Ma. Ángeles (María Ángeles); García-García, Isabel; Segura i Fàbregas, Bàrbara; Marqués Iturria, Idoia; Sender Palacios, María José; Tor, Encarnació; Prats Soteras, Xavier; Caldú i Ferrús, Xavier; Junqué i Plaja, Carme, 1955-; Pasternak, Ofer; Garolera i Freixa, Maite (Publication date: 2019-03-01)

Overweight and stress are both related to brain structural abnormalities. The allostatic load model states that frequent disruption of homeostasis is inherently linked to oxidative stress and inflammatory responses that ...