Institut de Neurociències (UBNeuro): Recent submissions
Now showing items 1-20 of 312
Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, ...
Human microglia-like cells differentiated from monocytes with GM-CSF and IL-34 show phagocytosis of α-synuclein aggregates and C/EBPβ-dependent proinflammatory activation
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using rodent microglial ...
Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease
Background: New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising ...
Long-lasting behavioral, molecular and functional connectivity alterations after chronic THC exposure during adolescence in mice
Heavy and daily use of cannabis with high contents of Delta 9-tetrahydrocannabinol (THC) during adolescence is associated with an increased risk of developing psychotic disorders later in life. Here, we treated mice with ...
The PADRIS-PRESTO Cohort: A Comprehensive Population-Based Study on Mental Health in Catalonia
Background: Mental disorders affect nearly 970 million people worldwide, impacting individuals and healthcare systems. Large population databases offer insights often unattainable in smaller studies, but their findings may ...
Boolean analysis shows a high proportion of dopamine D<sub>2</sub> receptors interacting with adenosine A<sub>2A</sub> receptors in striatal medium spiny neurons of mouse and non-human primate models of Parkinson's disease
The antagonistic effect of adenosine on dopaminergic transmission in the basal ganglia indirect motor control pathway is mediated by dopamine D2 (D2R) and adenosine A2A (A2AR) receptors co-expressed on medium spiny striatal ...
Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier
Due to the physical and physiological properties of the blood-brain barrier (BBB), the transport of neurotherapeutics from blood to brain is still a pharmaceutical challenge. We previously conducted a series of experiments ...
JNK signaling and its impact on neural cell maturation and differentiation
C-Jun-N-terminal-kinases (JNKs), members of the mitogen-activated-protein-kinase family, are significantly linked with neurological and neurodegenerative pathologies and cancer progression. However, JNKs serve key roles ...
Early childhood predictors of teen dating violence involvement at age 17
The distal relationship between risk factors in childhood and subsequent dating violence in late adolescence has not often been explored using longitudinal data. This study aims to shed light on the problem of dating ...
Amyotrophic Lateral Sclerosis Is Accompanied by Protein Derangements in the Olfactory Bulb-Tract Axis
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ...
Self-reported sleep relates to hippocampal atrophy across the adult lifespan: results from the Lifebrain consortium
Objectives: Poor sleep is associated with multiple age-related neurodegenerative and neuropsychiatric conditions. The hippocampus plays a special role in sleep and sleep-dependent cognition, and accelerated hippocampal ...
First Organoid Intelligence (OI) workshop to form an OI community
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while ...
Functional Interaction Between Caveolin 1 and LRRC8-Mediated Volume-Regulated Anion Channel
Volume-regulated anion channel (VRAC), constituted by leucine-rich repeat-containing 8 (LRRC8) heteromers, is crucial for volume homeostasis in vertebrate cells. This widely expressed channel has been associated with ...
Pharmacogenetic Modulation of STEP improves motor and cognitive function in a mouse model of Huntington's disease.
Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expansion of a CAG repeat in the huntingtin (htt) gene, which results in an aberrant form of the protein (mhtt). This leads to motor and ...
Validation of the Spanish version of the Irrational Procrastination Scale (IPS)
The present study is centered in adapting and validating a Spanish version of the Irrational Procrastination Scale (IPS). The sample consists of 365 adults aged 18-77 years (M = 37.70, SD = 12.64). Participants were ...
In Memory of Hagop Akiskal
The death of Hagop Akiskal left a great void in all who knew him, and many of us knew him, indeed, all over the world. Hagop was an attentive clinician and innovative researcher as well as a mentor who accompanied the ...
Does It Look Good or Evil? Children's Recognition of Moral Identities in Illustrations of Characters in Stories
Children usually use the external and physical features of characters in movies or stories as a means of categorizing them quickly as being either good or bad/evil. This categorization is probably done by means of heuristics ...
New perspectives on corpora amylacea in the human brain
Corpora amylacea are structures of unknown origin and function that appear with age in human brains and are profuse in selected brain areas in several neurodegenerative conditions. They are constituted of glucose polymers ...
Neural encoding of speech-in-noise in neonates: A frequency-following response study
Background noise disrupts the neural encoding of speech, making it particularly challenging to extract a speaker's voice from competing voices-an ability crucial for successful speech processing and communication. This ...
A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse
Axonal growth and guidance rely on correct growth cone responses to guidance cues. Unlike the signaling cascades that link axonal growth to cytoskeletal dynamics, little is known about the crosstalk mechanisms between ...
