Institut de Neurociències (UBNeuro): Recent submissions
Now showing items 1-20 of 312
Adult-specific Reelin expression alters striatal neuronal organization. Implications for neuropsychiatric disorders.
In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, ...
Human microglia-like cells differentiated from monocytes with GM-CSF and IL-34 show phagocytosis of α-synuclein aggregates and C/EBPβ-dependent proinflammatory activation
Microglia, the main resident immune cells in the central nervous system, are implicated in the pathogenesis of various neurological disorders. Much of our knowledge on microglial biology was obtained using rodent microglial ...
Dense core vesicle markers in CSF and cortical tissues of patients with Alzheimer's disease
Background: New fluid biomarkers for Alzheimer's disease (AD) that reveal synaptic and neural network dysfunctions are needed for clinical practice and therapeutic trial design. Dense core vesicle (DCV) cargos are promising ...
Long-lasting behavioral, molecular and functional connectivity alterations after chronic THC exposure during adolescence in mice
Heavy and daily use of cannabis with high contents of Delta 9-tetrahydrocannabinol (THC) during adolescence is associated with an increased risk of developing psychotic disorders later in life. Here, we treated mice with ...
The PADRIS-PRESTO Cohort: A Comprehensive Population-Based Study on Mental Health in Catalonia
Background: Mental disorders affect nearly 970 million people worldwide, impacting individuals and healthcare systems. Large population databases offer insights often unattainable in smaller studies, but their findings may ...
Neural encoding of speech-in-noise in neonates: A frequency-following response study
Background noise disrupts the neural encoding of speech, making it particularly challenging to extract a speaker's voice from competing voices-an ability crucial for successful speech processing and communication. This ...
Ciberacoso y ansiedad social en adolescentes: una revisión sistemática
El ciberbullying ha suscitado el interés de los investigadores en el campo de la psicología. Una de las variables que se ha estudiado en los últimos años en relación con el ciberbullying es la ansiedad social. Sin embargo, ...
State-dependent skin temperature increase during manic episodes of bipolar disorder
Skin temperature changes during mood episodes and can be continuously monitored through wearable devices, potentially serving as a digital biomarker. We aimed to describe differences in skin temperature among bipolar ...
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood
Background/objectives Excessive body mass index (BMI) has been linked to a low-grade chronic inflammation state. Unhealthy BMI has also been related to neuroanatomical changes in adults. Research in adolescents is relatively ...
Using fMRI to assess brain activity in people with Down Syndrome: A systematic review
Background: In the last few years, many investigations have focused on brain activity in general and in populations with different pathologies using non-invasive techniques such as electroencefalography (EEG), positron ...
Does It Look Good or Evil? Children's Recognition of Moral Identities in Illustrations of Characters in Stories
Children usually use the external and physical features of characters in movies or stories as a means of categorizing them quickly as being either good or bad/evil. This categorization is probably done by means of heuristics ...
Pyrethroids inhibit K2P channels and activate sensory neurons: basis of insecticide-induced paraesthesias
Pyrethroid insecticides are widely used for pest control in agriculture or in human public health commonly as a topical treatment for scabies and head lice. Exposure to pyrethroids such as permethrin or tetramethrin (TM) ...
Postnatal Foxp2 regulates early psychiatric-like phenotypes and associated molecular alterations in the R6/1 transgenic mouse model of Huntington's disease
Huntington's Disease (HD) is a devastating disorder characterized by a triad of motor, psychiatric and cognitive manifestations. Psychiatric and emotional symptoms appear at early stages of the disease which are consistently ...
Sex differences in brain and cognition in de novo Parkinson's disease
Background and objective: Brain atrophy and cognitive impairment in neurodegenerative diseases are influenced by sex. We aimed to investigate sex differences in brain atrophy and cognition in de novo Parkinson's disease ...
One year follow-up of a randomized trial with a dilema-focused intervention for depression: Exploring an alternative to problem-oriented strategies
Background Cognitive behavioural therapy (CBT) is aimed to counteract cognitions and behaviours that are considered as dysfunctional. The aim of the study is to test whether the inclusion of a non-counteractive approach ...
Exploring drug-receptor interaction kinetics: Lessons from a sigma-1 receptor transmembrane biosensor
An important field of study in pharmacology comprises the investigation of drug-target interaction kinetics. Thus, assessing both the lifetime of a drug on its receptor (i.e., drug-target residence time; Copeland, 2016) ...
Stem Cells for Huntington's Disease (SC4HD): An International Consortium to Facilitate Stem Cell-Based Therapy for Huntington's Disease
Huntington's disease (HD) research is entering an exciting phase, with new approaches such as huntingtin lowering strategies and cell therapies on the horizon. Technological advances to direct the differentiation of stem ...
Genetic and psychosocial stressors have independent effects on the level of subclinical psychosis: findings from the multinational EU-GEI study
Aims: Gene x environment (G×E) interactions, i.e. genetic modulation of the sensitivity to environmental factors and/or environmental control of the gene expression, have not been reliably established regarding aetiology ...
Lipidomic traits of plasma and cerebrospinal fluid in amyotrophic lateral sclerosis correlate with disease progression
Since amyotrophic lateral sclerosis cases exhibit significant heterogeneity, we aim to investigate the association of lipid composition of plasma and CSF with amyotrophic lateral sclerosis diagnosis, its progression and ...
Retinal structure and its relationship with premorbid, clinical, and cognitive variables in young Spanish patients with early course schizophrenia spectrum disorders
Emerging evidence suggests that retinal structural alterations are present in schizophrenia spectrum disorders (SSD), potentially reflecting broader neurodevelopmental and neurodegenerative processes. This cross-sectional ...
