Institut de Biomedicina (IBUB): Recent submissions
Now showing items 121-140 of 330
Synthesis of Dibenzo[b,e]azepin-11-ones by Intramolecular Palladium-Catalyzed Acylation of Aryliodides with Aldehydes
The paper describes an efficient methodology for the synthesis of diversely functionalized dihydrodibenzo[b,e]azepin-11-ones based on the Pd(0)-catalyzed intramolecular acylation of aryl iodides with aldehydes.
Immunometabolic effect of Nitric oxide on human macrophages challenged with the SARS-CoV2-induced cytokine storm. A fluxomic approach
The cytokine storm associated with SARS-CoV-2 infection is one of the most distinctive pathological signatures in COVID-19 patients. Macrophages respond to this pro-inflammatory challenge by reprogramming their functional ...
Effects of maternal fructose intake on perinatal ER-Stress: A defective XBP1s nuclear translocation affects the ER-stress resolution
Endoplasmic reticulum (ER) homeostasis is crucial to appropriate cell functioning, and when disturbed, a safeguard system called unfolded protein response (UPR) is activated. Fructose consumption modifies ER homeostasis ...
Thioflavin-S staining of bacterial inclusion bodies for the fast, simple, and inexpensive screening of amyloid aggregation inhibitors
Amyloid aggregation is linked to a large number of human disorders, from neurodegenerative diseases as Alzheimer"s disease (AD) or spongiform encephalopathies to non-neuropathic localized diseases as type II diabetes and ...
Identification of ADHD risk genes in extended pedigrees by combining linkage analysis and whole-exome sequencing
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder with a complex genetic background, hampering identification of underlying genetic risk factors. We hypothesized that combining linkage ...
Estimation of the critical micelle concentration of sodium taurocholate inintestine-relevant conditions using complimentary techniques
Bile salts such as sodium taurocholate (NaTc) play an important role in drugs’ bioavailability due to their capacityto form micelles. These aggregates can host a wide range of drugs and enhance their solubility in ...
In vitro gene delivery in retinal pigment epithelium cells by plasmid DNA-wrapped gold nanoparticles
Many rare diseases course with affectation of neurosensory organs. Among them, the neuroepithelial retina is very vulnerable due to constant light/oxidative stress, but it is also the most accessible and amenable to gene ...
The genome-wide associated candidate gene ZNF804A and psychosis-proneness: Evidence of sex-modulated association
Background: The Zinc finger protein 804A (ZNF804A) is a promising candidate gene for schizophrenia and the broader psychosis phenotype that emerged from genome-wide association studies. It is related to neurodevelopment ...
Hydrogen Atom Transfer (HAT)-Triggered Iron-Catalyzed Intra- and Intermolecular Coupling of Alkenes with Hydrazones: Access to Complex Amines
A methodology for the coupling of alkenes with aldehyde- or ketone-derived Cbz-hydrazones to form a new C−C bond through a radical process is described. The sequence comprises an initial in situ generation of a putative ...
Cross-disorder genetic analyses implicate dopaminergic signaling as a biological link between Attention-Deficit/Hyperactivity Disorder and obesity measures
Attention-Deficit/Hyperactivity Disorder (ADHD) and obesity are frequently comorbid, genetically correlated, and share brain substrates. The biological mechanisms driving this association are unclear, but candidate systems, ...
Contribution of Common Genetic Variants to Risk of Early-Onset Ischemic Stroke
Background and objectives: Current genome-wide association studies of ischemic stroke have focused primarily on late-onset disease. As a complement to these studies, we sought to identify the contribution of common genetic ...
Improving Photodynamic Therapy Anticancer Activity of a Mitochondria-Targeted Coumarin Photosensitizer Using a Polyurethane−Polyurea Hybrid Nanocarrier
Integration of photosensitizers (PSs) within nanoscale delivery systems offers great potential for overcoming some of the 'Achiles' heels' of photodynamic therapy (PDT). Herein, we have encapsulated a mitochondria-targeted ...
Synthesis of (±)-Serralongamine A and the Revised Structure of Huperzine N
A revised structure for the Lycopodium alkaloid huperzine N is proposed and confirmed by synthesis. The key synthetic steps involve an epimerization of a cis-5-oxodecahydroquinoline to the corresponding trans isomer and a ...
Targeting FGF21 for the treatment of nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH), the severe stage of nonalcoholic fatty liver disease (NAFLD), is defined as the presence of hepatic steatosis with inflammation, hepatocyte injury, and different degrees of fibrosis. ...
Determination of the aqueous pKa of very insoluble drugs by capillary electrophoresis: Internal standards for methanol-water extrapolation
A fast determination of acidity constants (pKa) of very insoluble drugs has become a necessity in drug discovery process because it often produces molecules that are highly lipophilic and sparingly soluble in water. In ...
Fructose effects on human health: Molecular insights from experimental models
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/63704
Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD
The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased drastically due to the global obesity pandemic but at present there are no approved therapies. Here, we aimed to revert high-fat diet (HFD)-induced ...
Hepatic regulation of VLDL receptor by PPARbeta/delta and FGF21 modulates non-alcoholic fatty liver disease
OBJECTIVE: The very low-density lipoprotein receptor (VLDLR) plays an important role in the development of hepatic steatosis. In this study, we investigated the role of Peroxisome Proliferator-Activated Receptor (PPAR)beta/delta ...
Planarian Cell Number Depends on blitzschnell, a Novel Gene Family That Balances Cell Proliferation and Cell Death
Control of cell number is crucial to define body size during animal development and to restrict tumoral transformation. The cell number is determined by the balance between cell proliferation and cell death. Although many ...
Fructose induces synthesis and reduces oxidation of liver fatty acids through ChREBP activation
Introduction and aims. During last few decades, the prevalence of obesity, metabolic syndrome and insulin resistance, among other metabolic disturbances, has raised considerably in many countries worldwide. Environmental ...
