Institut de Biomedicina (IBUB): Enviaments recents
Ara mostrant els elements 221-240 de 331
Type of supplemented simple sugar, not merely calorie intake, determines adverse effects on metabolism and aortic function in female rats.
High consumption of simple sugars causes adverse cardiometabolic effects. We investigated the mechanisms underlying the metabolic and vascular effects of glucose or fructose intake and determined whether these effects are ...
Fine tuning the extracellular environment accelerates the derivation of kidney organoids from human pluripotent stem cells
The generation of organoids is one of the biggest scientific advances in regenerative medicine. Here, by lengthening the time that human pluripotent stem cells (hPSCs) were exposed to a three-dimensional microenvironment, ...
Neuropsychopharmacologic and neurotoxicologic effects of the combination of ethanol with mephedrone in adolescent mice
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/103042
Structural model of the hUbA1-UbcH10 quaternary complex: In silico and experimental analysis of the protein-protein interactions between E1, E2 and ubiquitin
UbcH10 is a component of the Ubiquitin Conjugation Enzymes (Ubc; E2) involved in the ubiquitination cascade controlling the cell cycle progression, whereby ubiquitin, activated by E1, is transferred through E2 to the target ...
Use of infrared thermography to estimate brown fat activation after a cooling protocol in patients with severe obesity that underwent bariatric surgery
Background: In contrast to the energy-storing role of white adipose tissue (WAT), brown adipose tissue (BAT) acts as the main site of non-shivering thermogenesis in mammals and has been reported to play a role in protection ...
Effects of S-pindolol in mouse pancreatic and lung cancer cachexia models
Background: It is known that S-pindolol attenuates muscle loss in animal models of cancer cachexia and sarcopenia. In cancer cachexia, it also significantly reduced mortality and improved cardiac function, which is strongly ...
Stereoselective total synthesis of the putative structure of nitraraine
After the structure originally proposed for nitraraine was shown to be incorrect by total synthesis, the alternative structure 5 was recently suggested for the alkaloid on biosynthetic grounds and by comparison with the ...
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epidermal growth factor receptor for microsatellite stable tumors and pembrolizumab for microsatellite ...
Enhancing hepatic fatty acid oxidation as a strategy for reversing metabolic disorders programmed by maternal undernutrition during gestation
Background/Aims: Moderate maternal calorie-restriction during gestation programmes offspring for a major propensity to develop metabolic alterations in adulthood. We aimed to assess whether increased hepatic fatty-acid ...
Circulating metabolic markers after surgery identify patients at risk for severe postoperative complications: a prospective cohort study in colorectal cancer
Background: Early detection of postoperative complications after colorectal cancer (CRC) surgery is associated with improved outcomes. The aim was to investigate early metabolomics signatures capable to detect patients at ...
Can Förster Theory Describe Stereoselective Energy Transfer Dynamics in a Protein-Ligand Complex?
Förster resonance energy transfer (FRET) reactions involving ligands and aromatic amino acids can substantially impact the fluorescence properties of a protein-ligand complex, an impact intimately related to the corresponding ...
Mutation of amphioxus Pdx and Cdx demonstrates conserved roles for ParaHox genes in gut, anus and tail patterning
Background: The homeobox genes Pdx and Cdx are widespread across the animal kingdom and part of the small ParaHox gene cluster. Gene expression patterns suggest ancient roles for Pdx and Cdx in patterning the through-gut ...
Volume and composition of semi-adsorbed stationary phases in hydrophilic interaction liquid chromatography. Comparison of water adsorption in common stationary phases and eluents.
Pycnometric and homologous series retention methods are used to determine the volume and mean composition of the water-rich layers partially adsorbed on the surface of several hydrophilic interaction liquid chromatography ...
Enantioselective synthesis of lepadins A D from a phenylglycinol-derived hydroquinolone lactam
The marine alkaloids (-)-lepadins A-C and (+)-lepadin D, belonging to two diastereoisomeric series, were synthesized from an (R)-phenylglycinol-derived tricyclic lactam via a common cis-decahydroquinoline intermediate. ...
Influence of Ionization and the Addition of Cyclodextrins andHydrophilic Excipients on the Solubility of Benzthiazide,Isoxicam, and Piroxicam
Background: The bioavailability of a drug depends, among other parameters,on solubility. One of the strategies used to enhance the solubility of sparingly solubledrugs is the use of excipients. Excipients can interact with ...
Cyclin A1 is essential for setting the pluripotent state and reducing tumorigenicity of induced pluripotent stem cells
The proper differentiation and threat of cancer rising from the application of induced pluripotent stem (iPS) cells are major bottlenecks in the field and are thought to be inherently linked to the pluripotent nature of ...
Characterization of biosurfactants' micelles formation using flu-orescence measurements: sodium taurocholate as case of study
Background and purpose:The evaluation of micellization parameters of surfactants that aggregate gradually, such as bile salts, is not trivial. In this work,different probes and data treatment models are tested to ...
Exploring N-acyl-4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-enes as 11β-HSD1 inhibitors
We recently found that a cyclohexanecarboxamide derived from 4-azatetracyclo[5.3.2.02,6.08,10]dodec-11-ene displayed low nanomolar inhibition of 11β-HSD1. In continuation of our efforts to discover potent and selective ...
WNT-FRIZZLED-LRP5/6 Signaling Mediates Posterior Fate and Prolifer-ation during Planarian Regeneration
An organizer is defined as a group of cells that secrete extracellular proteins that specify the fate of surrounding cells according to their concentration. Their function during embryogenesis is key in patterning new ...
Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs
Background: Nucleoside analogs used in the chemotherapy of solid tumors, such as the capecitabine catabolite 50-deoxy-5-fluorouridine (50-DFUR) trigger a transcriptomic response that involves the aquaglyceroporin aquaporin ...
