IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer: Recent submissions
Now showing items 221-240 of 3164
Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells
A model of K-Ras-initiated lung cancer was used to follow the transition of precancerous adenoma to adenocarcinoma. In hypoxic, Tgf-β1-rich interiors of adenomas, we show that adenoma cells divide asymmetrically to produce ...
Resemblance of the human liver sinusoid in a fluidic device with biomedical and pharmaceutical applications
Maintenance of the complex phenotype of primary hepatocytes in vitro represents a limitation for developing liver support systems and reliable tools for biomedical research and drug screening. We herein aimed at developing ...
Passive exposure to electronic cigarette aerosol in pregnancy: A case study of a family
Background Passive exposure to the aerosols of electronic cigarettes (e-cigarettes) has been little studied. We assessed this exposure in late pregnancy in a woman and her 3-year-old child, exposed through e-cigarette use ...
Liraglutide improves liver microvascular dysfunction in cirrhosis: Evidence from translational studies
Hepatic stellate cells (HSC) play a key role in the development of chronic liver disease (CLD). Liraglutide, well-established in type 2 diabetes, showed anti-inflammatory and anti-oxidant properties. We evaluated the effects ...
The role of peroral cholangioscopy in liver transplant recipients: A prospective, international series
Background Biliary strictures are a common complication of living and deceased donor liver transplantation. Peroral cholangioscopy (POCS) with POCS-guided biliary tract biopsies may improve diagnostic accuracy compared ...
Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities
Chronic rhinosinusitis (CRS) is a heterogeneous, multifactorial inflammatory disease of the nasal and paranasal mucosa. It has not been possible to date to develop an internationally standardized, uniform classification ...
MOG encephalomyelitis: international recommendations on diagnosis and antibody testing
Over the past few years, new-generation cell-based assays have demonstrated a robust association of autoantibodies to full-length human myelin oligodendrocyte glycoprotein (MOG-IgG) with (mostly recurrent) optic neuritis, ...
Increased rate of FEV1 decline in HIV patients despite effective treatment with HAART
Introduction: Previous studies have reported that the rate of FEV1 decline over time is increased in HIV patients but the mechanisms underlying this observation are unclear. Since current HIV treatment with Highly Active ...
Mixed hepatocellular cholangiocarcinoma tumors: Cholangiolocellular carcinoma is a distinct molecular entity
Background & Aims: Mixed hepatocellular cholangiocarcinoma (HCC-CCA) is a rare and poorly understood type of primary liver cancer. We aimed to perform a comprehensive molecular characterization of this malignancy.Methods: ...
Alteracions del DNA mitocondrial implicades en patologia Humana
La majoria del gens humans es localitzen al nucli de la cèl·lula i s'hereten d'ambdós progenitors. N'existeixen d'altres que es troben al citoplasma, concretament a l'interior dels mitocondris, i són d'origen exclusivament ...
Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial
Aims: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvencion con DIeta MEDiterrnea) primary ...
Image-Based Method to Quantify Decellularization of Tissue Sections
Tissue decellularization is typically assessed through absorbance-based DNA quantification after tissue digestion. This method has several disadvantages, namely its destructive nature and inadequacy in experimental situations ...
MicroCT imaging reveals differential 3D micro-scale remodelling of the murine aorta in ageing and Marfan syndrome
Aortic wall remodelling is a key feature of both ageing and genetic connective tissue diseases, which are associated with vasculopathies such as Marfan syndrome (MFS). Although the aorta is a 3D structure, little attention ...
Vitiliginous alopecia masquerading as frontal fibrosing alopecia
A 73‑year‑old female presented at the Dermatology Department with a white shiny band‑like patch on the temporal and forehead zones [Figure 1]. She had a 4‑year history of vulvar lichen scleroatrophicus (LSA) [Figure 2]. ...
Psychological burden of hepatic encephalopathy on patients and caregivers
Objectives: Hepatic encephalopathy (HE) is common in advanced cirrhosis and is characterized by marked neuropsychiatric abnormalities. However, despite its severity and effects on brain function, the impact of HE on ...
Integrating genetic, neuropsychological and neuroimaging data to model early-onset obsessive compulsive disorder severity
We propose an integrative approach that combines structural magnetic resonance imaging data (MRI), diffusion tensor imaging data (DTI), neuropsychological data, and genetic data to predict early-onset obsessive compulsive ...
Affective temperaments mediate aggressive dimensions in bipolar disorders: A cluster analysis from a large, cross-sectional, international study
Background: Affective temperaments show potential for aggressive behavior (AB) preventive strategies in bipolar disorder (BD). We aim to define intra-diagnostic subgroups of patients with BD based on homogeneous behaviors ...
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
The reanalysis of existing GWAS data represents a powerful and cost-effective opportunity to gain insights into the genetics of complex diseases. By reanalyzing publicly available type 2 diabetes (T2D) genome-wide association ...
Higher circulating Vitamin B12 is associated with lower levels of inflammatory markers in individuals at high cardiovascular risk and in naturally aged mice
Vitamin B12 is an essential nutrient that is involved in numerous physiological processes, and its deficiency can lead to various complications, including neurological and haematological disorders. Some studies have suggested ...
The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 1: Background and Methods of the Development of Guideline
Podeu consultar la part 2: http://hdl.handle.net/2445/116264
