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Título:	Integrating genetic, neuropsychological and neuroimaging data to model early-onset obsessive compulsive disorder severity
Autor/a:	Mas Herrero, Sergi; Gassó Astorga, Patricia; Morer Liñán, Astrid; Calvo, Anna; Bargalló Alabart, Núria​; Lafuente, Amàlia, 1952-; Lázaro García, Luisa
Notas:	We propose an integrative approach that combines structural magnetic resonance imaging data (MRI), diffusion tensor imaging data (DTI), neuropsychological data, and genetic data to predict early-onset obsessive compulsive disorder (OCD) severity. From a cohort of 87 patients, 56 with complete information were used in the present analysis. First, we performed a multivariate genetic association analysis of OCD severity with 266 genetic polymorphisms. This association analysis was used to select and prioritize the SNPs that would be included in the model. Second, we split the sample into a training set (N = 38) and a validation set (N = 18). Third, entropy-based measures of information gain were used for feature selection with the training subset. Fourth, the selected features were fed into two supervised methods of class prediction based on machine learning, using the leave-one-out procedure with the train- ing set. Finally, the resulting model was validated with the validation set. Nine variables were used for the creation of the OCD severity predictor, including six genetic polymorphisms and three variables from the neuropsychological data. The developed model classified child and adolescent patients with OCD by disease severity with an accuracy of 0.90 in the testing set and 0.70 in the validation sample. Above its clinical applicability, the combination of particular neuropsychological, neuroimaging, and genetic characteristics could enhance our under- standing of the neurobiological basis of the disorder.
Materia(s):	-Neurosi obsessiva -Neuropsicologia -Genètica humana -Ressonància magnètica -Diagnòstic per la imatge -Farmacogenètica -Obsessive-compulsive disorder -Neuropsychology -Human genetics -Magnetic resonance -Diagnostic imaging -Pharmacogenetics
Derechos:	cc-by (c) Mas Herrero et al., 2016 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Public Library of Science (PLoS)
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