Bump attractor dynamics in prefrontal cortex explains behavioral precision in spatial working memory 

Wimmer, Klaus; Nykamp, Duane Q.; Constantinidis, Christos; Compte, Albert (Data de publicació: 2024-03-05)

Prefrontal persistent activity during the delay of spatial working memory tasks is thought to maintain spatial location in memory. A 'bump attractor' computational model can account for this physiology and its relationship ...

Posverdad del consumo de cannabis: de regreso a la medicina basada en la evidencia 

López Pelayo, Hugo; Miquel de Montagut, Laia; Casajuana Kögel, Cristina; Balcells Oliveró, Maria Mercè (Data de publicació: 2020-03-09)

La opinión pública y científica sobre los efectos beneficios y perjudiciales del consumo regular de cannabis no está exenta del fenómeno de la posverdad. En esta editorial revisamos la evidencia científica de los efectos ...

Trends in the Prescription of Strong Opioids for Chronic Non-Cancer Pain in Primary Care in Catalonia: Opicat-Padris-Project 

Perelló Bratescu, Aina; Dürsteler, Christian; Álvarez Carrera, Maria Asunción; Granés, Laura; Kostov, Belchin; Sisó Almirall, Antoni (Data de publicació: 2023-08-02)

In chronic non-cancer pain (CNCP), evidence of the effectiveness of strong opioids (SO) is very limited. Despite this, their use is increasingly common. To examine SO prescriptions, we designed a descriptive, longitudinal, ...

Brugada Syndrome in Women: What Do We Know After 30 Years? 

Martínez Barrios, Estefanía; Arbelo, Elena; César Diaz, Sergio; Cruzalegui, José; Fiol, Victoria; Díez Escuté, Nuria; Hernández, Clara; Brugada, Ramon; Brugada Terradellas, Josep, 1958-; Campuzano Larrea, Oscar; Sarquella Brugada, Georgia (Data de publicació: 2023-06-21)

Brugada syndrome (BrS) was initially described in 1992 by Josep and Pedro Brugada as an arrhythmogenic disease characterized by ST segment elevation in the right precordial leads and increased risk of sudden cardiac death ...

Randomized trials and endpoints in advanced HCC: Role of PFS as a surrogate of survival 

Llovet i Bayer, Josep Maria; Montal, Robert; Villanueva, Augusto (Data de publicació: 2020-01-08)

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide. Around half of patients with HCC will receive systemic therapies during their life span. The pivotal positive sorafenib trial and ...

Enhanced Kidney Targeting and Distribution of Tubuloids During Normothermic Perfusion 

Montagud Marrahí, Enrique; Rodriguez Gonzalo, Adriana; López Aladid, Rubén; Luque, Yosu; Rabadán Ros, Ruben; Cuadrado Payán, Elena; Bañón Maneus, Elisenda; Rovira Juárez, Jordi; Lazo Rodríguez, Marta; Aguilà, Oriol; Arana Aliaga, Carolt; García Busquets, Ainhoa; Hierro, Natalia; Prudhomme, Thomas; Musquera Felip, Mireia; Xia, Yun; Diekmann, Fritz; Campistol, Josep M; Ramírez Bajo, María José (Data de publicació: 2025-11-14)

Tubuloids have become a promising tool for modeling and regenerating kidney disease, although their ability for integration and regeneration in vivo is not well documented. Here, we established, characterized, and compared ...

Tacrolimus-Associated Tremor in Renal Transplant Patients: Potential Impact of the Galenic Formulation. 

Rovira Juárez, Jordi; Millán, Olga; Ventura Aguiar, Pedro; Brunet, Mercè; Diekmann, Fritz (Data de publicació: 2025-12-02)

Background/Objectives: Tacrolimus is the most used immunosuppressive agent in solid organ transplantation due to its efficacy in preventing acute rejection, but it has a narrow therapeutic range, and overexposure often ...

Targeting HER2-AXL heterodimerization to overcome resistance to HER2 blockade in breast cancer 

Adam Artigues, Anna; Arenas Lahuerta, Enrique Javier; Martínez Sabadell, Alex; Brasó Maristany, Fara; Cervera, Raimundo; Tormo, Eduardo; Hernando, Cristina; Martínez, Maria Teresa; Carbonell Asins, Juan; Simón, Soraya; Poveda, Jesús; Moragón, Santiago; Zazo, Sandra; Martínez, Débora; Rovira, Ana; Burgues, Octavio; Rojo, Federico; Albanell Mestres, Joan; Bermejo, Begoña; Lluch Hernández, Ana; Prat Aparicio, Aleix; Arribas, Joaquín; Eroles, Pilar; Cejalvo, Juan Miguel (Data de publicació: 2023-04-27)

Anti-HER2 therapies have markedly improved prognosis of HER2-positive breast cancer. However, different mechanisms play a role in treatment resistance. Here, we identified AXL overexpression as an essential mechanism of ...

Impact of pre- and/or post-autologous stem cell transplantation exposure to brentuximab vedotin on survival outcomes in patients with high-risk Hodgkin lymphoma 

Martinez, Carmen; Haro, Manuel Espeso de; Romero, Samuel; Gutierrez, Antonio; Domingo Domènech, Eva; González Rodríguez, Ana P.; Zeberio, Izaskun; Martínez Badas, María Paz; Rodríguez Izquierdo, Antonia; Carpio, Cecilia; Bastos Oreiro, Mariana; Hernandez Rivas, Jose Angel; Vallansot, Rolando; Kelleher, Nicholas; Díaz Gálvez, Francisco J.; Torrado, Tamara; Pereira, Arturo; Garcia Sanz, Ramon (Data de publicació: 2024-03-25)

The AETHERA trial demonstrated that brentuximab vedotin (BV) consolidation after autologous stem cell transplantation (ASCT) in patients with Hodgkin lymphoma (HL) at high risk of relapse/progression increases progression-free ...

Interleukin-1 receptor associated kinase 1/4 and bromodomain and extra-terminal inhibitions converge on NF-κB blockade and display synergistic antitumoral activity in activated B-cell subset of diffuse large B-cell lymphoma with <i>MYD88</i> L265P mutation 

Dlouhy, Ivan; Armengol, Marc; Recasens Zorzo, Clara; Ribeiro, Marcelo L.; Pérez Galán, Patricia; Bosch, Francesc; López Guillermo, Armando; Roue, Gaël (Data de publicació: 2024-02-19)

Donor-derived Cell-free DNA Shows High Sensitivity for the Diagnosis of Pancreas Graft Rejection in Simultaneous Pancreas-Kidney Transplantation 

Abreu Aguiarà, Pedro Ventura; Ramírez Bajo, María José; Rovira Juárez, Jordi; Bañón Maneus, Elisenda; Hierro García, Natalia; Lazo Rodríguez, Marta; Cuatrecasas Freixas, Miriam; Garcia Criado, María Ángeles; Liang, Nathan; Swenerton, Ryan K.; Cofán Pujol, Federico; Cucchiari, David; Esforzado, Núria; Montagud Marrahi, Enrique; Oppenheimer Salinas, Federico; Piñeiro, Gastón Julio; Revuelta Vicente, Ignacio; Torregrosa, Vicens; Ahmed, Ebad; Soboleva, Karina; Kaur, Navchetan; Zimmermann, Bernhard G.; Al Haj Baddar, Nour; Demko, Zachary P.; Escrig, Cesar; Tabriziani, Hossein; Gauthier, Philippe; Billings, Paul R.; Amor Fernández, Antonio Jesús; Ferrer Fábrega, Joana; Campistol Plana, Josep M.; Diekmann, Fritz (Data de publicació: 2025-12-02)

Background. Pancreas graft status in simultaneous pancreas-kidney transplant (SPKTx) is currently assessed by nonspecific biochemical markers, typically mylase or lipase. Identifying a noninvasive biomarker with good ...

Beyond viral suppression of HIV - the new quality of life frontier 

Lazarus, Jeffrey V.; Safreed-Harmon, Kelly; Barton, Simon E.; Costagliola, Dominique; Dedes, Nikos; Amo Valero, Julia del; Gatell, José M.; Baptista-Leite, Ricardo; Mendao, Luis; Porter, Kholoud; Vella, Stefano; Rockstroh, Jürgen Kurt (Data de publicació: 2016-07-18)

BACKGROUND: In 2016, the World Health Organization (WHO) adopted a new Global Health Sector Strategy on HIV for 2016-2021. It establishes 15 ambitious targets, including the '90-90-90' ...

B Cell-Derived Extracellular Vesicles Reveal Residual B Cell Activity in Kidney Graft Recipients Undergoing Pre-Transplant Desensitization 

Cucchiari, David; Tubita, Valeria; Rovira Juárez, Jordi; Ramírez Bajo, María José; Bañón Maneus, Elisenda; Lazo Rodríguez, Marta; Hierro García, Natalia; Borràs, Francesc E.; Ventura Abreu Aguiarà, Pedro; Piñeiro, Gastón Julio; Martorell, Jaume; Peri, Lluis; Musquera Felip, Mireia; Hertig, Alexandre; Oppenheimer Salinas, Federico; Campistol Plana, Josep M.; Diekmann, Fritz; Revuelta Vicente, Ignacio (Data de publicació: 2025-12-03)

Background: Living-donor kidney transplant (LDKT) recipients undergoing desensitization for Human Leukocyte Antigen (HLA)-incompatibility have a high risk of developing antibody-mediated rejection (ABMR). The purpose of ...

Early-onset Alzheimer's disease shows a distinct neuropsychological profile and more aggressive trajectories of cognitive decline than late-onset 

Tort Merino, Adrià; Falgàs Martínez, Neus; Allen, I. E.; Balasa, M.; Olives, Jaume; Contador Muñana, José Miguel; Castellví, M.; Juncà Parella, J.; Guillen, N.; Borrego Écija, Sergi; Bosch, B.; Fernandez Villullas, G.; Ramos Campoy, O.; Antonell Boixader, Anna, 1978-; Rami González, Lorena; Sánchez Valle, Raquel; Lladó Plarrumaní, Albert (Data de publicació: 2024-03-25)

Early- and late-onset Alzheimer's disease (EOAD and LOAD) share the same neuropathological traits but show distinct cognitive features. We aimed to explore baseline and longitudinal outcomes of global and domain-specific ...

Paediatric and adolescent athletes in Switzerland: age-adapted proposals for pre-participation cardiovascular evaluation 

Albiński, Maciej; Balmer, Christian; Wilhelm, Matthias; Meyer, Philippe; Gass, Matthias; Schmied, Christian; Menafoglio, Andrea; Kriemler, Susanne; Mivelaz, Yvan; Stambach, Dominik; Saubade, Mathieu; Gremeaux, Aaron; Gojanovic, Boris; Brugada Terradellas, Josep, 1958-; Baggish, Aaron; Gabus, Vincent (Data de publicació: 2023-06-21)

High-level sports competition is popular among Swiss youth. Even though preparticipation evaluation for competitive athletes is widespread, screening strategies for diseases responsible for sudden death during sport are ...

Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study* 

Kayser. S.; Hills, R. K.; Langová, R.; Kramer, M.; Guijarro Tomàs, Francisca; Sustkova. Z,; Estey, E. H.; Shaw, C. M.; Racil, Z.; Mayer, J.; Zak, P.; Baer, M. R.; Brunner, A. M.; Szotkowski, T.; Cetkovsky, P.; Grimwade, D.; Walter, Roland B.; Burnett, A. K.; Ho, A. D.; Ehninger, G.; Müller Tidow, C.; Platzbecker, U.; Thiede, C.; Röllig, C.; Schulz, A.; Warsow, G.; Brors, B.; Esteve Reyner, Jordi; Russell, N. H.; Schlenk, R. F.; Levis, M. J. (Data de publicació: 2025-03-25)

In acute myeloid leukaemia (AML) t(8;16)(p11;p13)/MYST3–CREBBP is a very rare abnormality. Previous small series suggested poor outcome. We report on 59 patients with t(8;16) within an international, collaborative study. ...

Comprehensive data integration-Toward a more personalized assessment of diastolic function 

Loncaric, Filip; Cikes, Maja; Sitges Carreño, Marta; Bijnens, Bart (Data de publicació: 2020-07-15)

Background and aim: The main challenge of assessing diastolic function is the balance between clinical utility, in the sense of usability and time‐efficiency, and overall applicability, in the sense of precision for the ...

Benefits and harm of systemic steroids for short- And long-term use in rhinitis and rhinosinusitis: an EAACI position paper 

Hox, Valerie; Lourijsen, Evelijn; Jordens, Arnout; Aasbjerg, Kristian; Agache, Ioana; Alobid, Isam; Bachert, Claus; Boussery, Koen; Campo, Paloma; Fokkens, Wytske; Hellings, Peter; Hopkins, Claire; Klimek, Ludger; Mäkelä, Mika; Mösges, Ralph; Mullol i Miret, Joaquim; Pujols Tarrés, Laura; Rondon, Carmen; Rudenko, Michael; Toppila‑Salmi, Sanna; Scadding, Glenis; Scheire, Sophie; Tomazic, Peter‑Valentin; Van Zele, Thibaut; Wagemann, Martin; van Boven, Job F. M.; Gevaert, Philippe (Data de publicació: 2020-03-03)

Because of the inflammatory mechanisms of most chronic upper airway diseases such as rhinitis and chronic rhinosinusitis, systemic steroids have been used for their treatment for decades. However, it has been very well ...

Community-Acquired Pneumococcal Pneumonia in Virologically Suppressed HIV-Infected Adult Patients: A Matched Case-Control Study 

Cillóniz, Catia; Torres Martí, Antoni; Manzardo, Christian; Gabarrús, Albert; Ambrosioni, Juan; Salazar, Adriana; García, Felipe; Ceccato, Adrian; Mensa Pueyo, Josep; Puig de la Bellacasa, Jordi; Moreno Camacho, Ma. Asunción; Miró Meda, José M. (José María), 1956- (Data de publicació: 2019-11-25)

Background: The study aimed to investigate whether the clinical presentations and outcomes (length of stay, ICU admission, and 30-day mortality) of pneumococcal pneumonia in virologically suppressed patients who were ...

Fluorescent PLGA Nanocarriers for Pulmonary Administration: Influence of the Surface Charge 

Areny Balagueró, Aina; Mekseriwattana, Wid; Camprubí Rimblas, Marta; Stephany, Andrea; Roldán, Ariana; Solé Porta, Anna; Artigas, Antonio; Closa, Daniel, 1961-; Roig, Anna (Data de publicació: 2024-03-27)

Nearly four million yearly deaths can be attributed to respiratory diseases, prompting a huge worldwide health emergency. Additionally, the COVID-19 pandemic’s death toll has surpassed six million, significantly increasing ...