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Fonaments Clínics: Recent submissions

Now showing items 241-260 of 627

    Tuberculosis recurrence after completion treatment in a European city: reinfection or relapse? 

    Millet, Joan-Pau; Shaw Perujo, Evelyn; Orcau i Palau, Àngels; Casals, Martí; Miró Meda, José M. (José María), 1956-; Caylà i Buqueras, Joan A.; Gatell, José M.; Tudó i Vilanova, Griselda; Barcelona Tuberculosis Recurrence Working Group (Publication date: 2018-09-20)

    Background Tuberculosis (TB) recurrence can be due to reinfection or relapse. The contribution of each to TB incidence and the factors associated with recurrence are not well known. Effectiveness of TB control programs is ...

    Pro/anti-inflammatory disregulation in early psychosis: results from a longitudinal, case-control study 

    García Bueno, Borja; Bioque Alcázar, Miquel; MacDowell, Karina S.; Santabárbara, Javier; Martínez Cengotitabengoa, Mónica; Moreno, Carmen (Moreno Koch); Saiz, Pilar A.; Berrocoso, Esther; Gassó Astorga, Patricia; Barcones, M. Fe; González-Pinto, Ana; Parellada, Mara; Bobes García, Julio; Micó, Juan Antonio; Bernardo Arroyo, Miquel; Leza, Juan Carlos (Publication date: 2017-06-12)

    Background: Previous studies indicated a systemic deregulation of the pro-/antiinflammatory balance in subjects after 6 months of a first psychotic episode. This disruption was reexamined 12 months after diagnosis to ...

    Prosthetic joint infection by Bordetella holmesii: Case report and a review of the literature 

    Fernández Pittol, Mariana José; Bosch Mestres, Jordi; Morata, Laura; Lozano, Luis; Martínez Pastor, Juan Carlos; Soriano Viladomiu, Alex (Publication date: 2020-05-11)

    Introduction: Bordetella holmesii is a Gram-negative coccobacillus involved in different infections mostly described in case reports. Prosthetic joint infections in relation to this pathogen are rare. Here, we present the ...

    GPR56/ADGRG1 inhibits mesenchymal differentiation and radioresistance in glioblastoma 

    Moreno Monasterio, Marta; Pedrosa, Leire; Paré Brunet, Laia; Pineda, Estela; Bejarano, Leire; Martínez Soler, Fina; Balasubramaniyan, Veerakumar; Ezhilarasan, Ravesanker; Kallarackal, Naveen; Kim, Sung-Hak; Wang, Jia; Audia, Alessandra; Conroy, Siobhan; Marín Aguilera, Mercedes; Ribalta Farrés, Teresa María; Pujol Farré, Teresa; Herreros, Antonio; Tortosa i Moreno, Avelina; Mira, Helena; Alonso, Marta M.; Gómez-Manzano, Candelaria; Graus Ribas, Francesc; Sulman, Erik P.; Piao, Xianhua; Nakano, Ichiro; Prat Aparicio, Aleix; Bhat, Krishna P.; Iglesia, Núria de la (Publication date: 2018-01-09)

    A mesenchymal transition occurs both during the natural evolution of glioblastoma (GBM) and in response to therapy. Here, we report that the adhesion G-protein-coupled receptor, GPR56/ADGRG1, inhibits GBM mesenchymal ...

    The Contribution of QF-PCR and pathology studies in the diagnosis of diandric triploidy/partial mole 

    Benitez, Leticia; Pauta, Montse; Badenas Orquin, Celia; Madrigal Bajo, Irene; Nadal Serra, Alfons; Marimon, Edda; Borrell, Antoni (Publication date: 2021-11-11)

    Objective: the aim of our study was to assess the contribution of quantitative fluorescent polymerase chain reaction (QF-PCR) and pathology studies in the diagnosis of diandric triploidies/partial hydatidiform moles. ...

    The natural hallucinogen 5-MeO-DMT, component of Ayahuasca, disrupts cortical function in rats: reversal by antipsychotic drugs 

    Riga, Maurizio S.; Soria, Guadalupe; Tudela Fernández, Raúl; Artigas Pérez, Francesc; Celada Pedrosa, Paz (Publication date: 2015-04-24)

    5-Methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a natural hallucinogen component of Ayahuasca, an Amazonian beverage traditionally used for ritual, religious and healing purposes that is being increasingly used for ...

    Magnetic resonance for assessment of disease activity and severity in ileocolonic Crohn's disease. 

    Rimola Gibert, Jordi; Rodríguez, S.; García Bosch, Orlando; Ordás, I.; Ayala, Edgar; Aceituno, Montserrat; Pellisé Urquiza, Maria; Ayuso Colella, Carmen; Ricart, Elena; Donoso Bach, Lluís; Panés Díaz, Julià (Publication date: 2011-07-07)

    Assessment of disease extension and activity is crucial to guide treatment in Crohn’s disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment...

    Bacterial co-infection at hospital admission in patients with COVID-19 

    Moreno García, Estela; Puerta-Alcalde, Pedro; Letona Giménez, Laura; Meira, Fernanda; Dueñas, Gerard; Chumbita, Mariana; García Pouton, Nicole; Monzó Gallo, Patricia; Lopera, Carlos; Serra, Laia; Cardozo Espinola, Celia; Hernández-Meneses, Marta; Rico, Verónica; Bodro, Marta; Morata, Laura; Fernández Pittol, Mariana José; Grafia, Ignacio; Castro, Pedro; Mensa Pueyo, Josep; Martínez, José Antonio; Sanjuan, Gemma; Marcos, Ma. Angeles; Soriano Viladomiu, Alex; Garcia Vidal, Carolina; Hospital Clinic of Barcelona COVID-19 Research Group (Publication date: 2023-05-29)

    Objectives: We described the current incidence and risk factors of bacterial co-infection in hospitalized patients with COVID-19. Methods: Observational cohort study was performed at the Hospital Clinic of Barcelona (February ...

    Effect of time to sentinel-node biopsy on the prognosis of cutaneous melanoma 

    Tejera Vaquerizo, Antonio; Nagore, Eduardo; Puig i Sardà, Susana; Robert, Caroline; Saiag, Philippe; Martín-Cuevas, Paula; Gallego, Elena; Herrera Acosta, Enrique; Aguilera, José; Malvehy, J. (Josep); Carrera Álvarez, Cristina; Cavalcanti, Andrea; Rull, Ramón; Vilalta Solsona, Antonio; Lannoy, Emilie; Boutros, Celine; Benannoune, Naima; Tomasic, Gorana; Aegerte, Philippe; Vidal i Sicart, Sergi; Palou, Josep; Alós i Hernández, Llúcia; Requena, Celia; Traves, Víctor; Pla, Ángel; Bolumar, Isidro; Soriano, Virtudes; Guillén, Carlos; Herrera Ceballos, Enrique (Publication date: 2019-03-19)

    Introduction: In patients with primary cutaneous melanoma, there is generally a delay between excisional biopsy of the primary tumour and sentinel-node biopsy. The objective of this study is to analyse the prognostic ...

    Genomic complexity and IGHV mutational status are key predictors of outcome of chronic lymphocytic leukemia patients with TP53 disruption. 

    Delgado, Julio (Delgado González); Salaverria Frigola, Itziar; Baumann, Tycho; Martínez Trillos, Alejandra; Lee, Eriong; Jiménez, Laura; Navarro López, Alba; Royo Moreno, Cristina; Santacruz, Rodrigo; López González, Cristina; Payer, Ángel R.; Colado, Enrique; González, Marcos; Armengol, Lluís; Colomer Pujol, Dolors; Pinyol, Magda; Villamor i Casas, Neus; Aymerich Gregorio, Marta; Carrió, Ana; Costa, Dolors; Clot Razquin, Guillem; Giné Soca, Eva; López Guillermo, Armando; Campo Güerri, Elias; Beà Bobet, Sílvia M. (Publication date: 2018-03-27)

    The clinical course of chronic lymphocytic leukemia (CLL) is extremely heterogeneous and while some patients achieve a normal lifespan, others succumb to the disease shortly after diagnosis. Recurrent chromosomal aberrations ...

    Cortical macro- and microstructural changes in isolated rapid eye movement sleep behavior disorder 

    Pardo, Jèssica; Roura, Ignacio; Montal, Victor; Martín Barceló, Cristina; Oltra González, Javier; Campabadal Delgado, Anna; Bargalló Alabart, Núria; Serradell, Mónica; Mayà Casalprim, Gerard; Montini, Angelica; Gaig, Carles; Pont Sunyer, Claustre; Fortea, Juan; Iranzo, Alex; Junqué i Plaja, Carme, 1955-; Segura i Fàbregas, Bàrbara (Publication date: 2026-01-21)

    Cortical mean diffusivity (cMD), a marker of cortical microstructural changes in neurodegenerative disorders, remains unexplored in isolated REM sleep behavior disorder (iRBD), a prodromal stage of Lewy body (LB) diseases. ...

    Emergence of progressive mutations in SARS-CoV-2 from a hematologic patient with prolonged viral replication 

    Garcia Vidal, Carolina; Iglesias, María; Puerta-Alcalde, Pedro; Mas, Vicente; Cuesta Chasco, Genoveva; García Pouton, Nicole; Varona, Sarai; Pozo, Francisco; Vázquez Morón, Sonia; Marcos, Ma. Angeles; Soriano Viladomiu, Alex; Casas Flecha, Inmaculada; HEMATOCOVID19-Researchers Group (Publication date: 2023-05-12)

    We documented a hematologic patient with prolonged SARS-CoV-2 viral replication in whom emergence of viral mutations was documented after the consecutive use of antivirals and convalescent plasma. The virus detected in the ...

    Cell-Cycle-Dependent Reconfiguration of the DNA Methylome during Terminal Differentiation of Human B Cells into Plasma Cells 

    Caron, Gersende; Hussein, Mourad; Kulis, Marta; Delaloy, Céline; Chatonnet, Fabrice; Pignarre, Amandine; Avner, Stéphane; Lemarié, Maud; Mahé, Elise A.; Verdaguer Dot, Núria; Queirós, Ana C.; Tarte, Karin; Martín-Subero, José Ignacio; Salbert, Gilles; Fest, Thierry (Publication date: 2020-02-13)

    Molecular mechanisms underlying terminal differentiation of B cells into plasma cells are major determinants of adaptive immunity but remain only partially understood. Here we present the transcriptional and epigenomic ...

    Vertebral fracture risk in glucocorticoid-induced osteoporosis: the role of hypogonadism and corticosteroid boluses 

    Florez, Helena; Hernández Rodríguez, José; Carrasco Jordan, Josep Lluís; Prieto González, Sergio; Muxí Pradas, África; Filella Pla, Xavier; Ruiz-Gaspa, Silvia; Gomez Puerta, José A.; Cid Xutglà, M. Cinta; Espinosa Garriga, Gerard; Monegal Brancós, Ana; Guañabens Gay, Núria; Peris Bernal, Pilar (Publication date: 2021-02-19)

    Objective: The aim of this study was to identify the risk factors associated with fragility fracture (FF) development in glucocorticoid (GC)-treated patients. Methods: 127 patients (aged 62±18 years, 63% women) on GC-treatment ...

    miR-141 and miR-200c as markers of overall survival in early stage non-small cell lung cancer adenocarcinoma 

    Tejero Villalba, Rut; Navarro Ponz, Alfons; Campayo Guillaumes, Marc; Viñolas Segarra, Núria; Marrades Sicart, Ramon Ma.; Cordeiro Santanach, Anna; Ruíz Martínez, Marc; Santasusagna, Sandra; Molins López-Rodó, Laureano; Ramírez Ruz, J. (José); Monzó Planella, Mariano (Publication date: 2020-01-23)

    Several treatments in non-small cell lung cancer (NSCLC) are histology-dependent, and the need for histology-related markers is increasing. MicroRNAs (miRNAs) are promising molecular markers in multiple cancers and show ...

    CCND2 and CCND3 hijack immunoglobulin light chain enhancers in cyclin D1-negative mantle cell lymphoma 

    Martín García, David; Navarro López, Alba; Valdés Mas, Rafael; Clot Razquin, Guillem; Gutiérrez-Abril, Jesús; Prieto, Miriam; Ribera Cortada, Inmaculada; Woroniecka, Renata; Rymkiewicz, Grzegorz; Bens, Susanne; Leval, Laurence de; Rosenwald, Andreas; Ferry, Judith A.; Hsi, Eric D.; Fu, Kai; Delabie, Jan; Weisenburger, Dennis D.; Jong, Daphne de; Climent, Fina; O'Connor, Sheila J.; Swerdlow, Steven H.; Torrents Arenales, David; Beltran i Agulló, Sergi; Espinet Solà, Blanca; González Farré, Blanca; Veloza, Luis; Costa, Dolors; Matutes, Estella; Siebert, Reiner; Ott, German; Quintanilla Martinez, Leticia; Jaffe, Elaine S.; López-Otin, Carlos; Salaverria Frigola, Itziar; Puente, Xose S.; Campo Güerri, Elias; Beà Bobet, Sílvia M. (Publication date: 2020-01-09)

    Mantle cell lymphoma (MCL) is characterized by the t(11;14)(q13;q32) translocation resulting in overexpression of cyclin D1. However, a small subset of cyclin D1− MCL has been recognized, and approximately one-half of them ...

    Prevalence, clinical characteristics and outcome of severe primary HIV-1 infection: a prospective cohort study 

    Nicolás, David; Suárez, Antonio; Ambrosioni, Juan; Manzardo, Christian; Ligero, Carmen; Costa, Josep; Fernández, Emma; Marcos, Ma. Angeles; Plana Prades, Montserrat; Mosquera, Maria Mar; Sánchez-Palomino, Sonsoles; Gatell, José M.; Miró Meda, José M. (José María), 1956- (Publication date: 2020-05-19)

    Background: Severe cases of primary HIV infection have been described in patients presenting with neurological involvement, AIDS defining events or other life-threatening events. These severe forms have not been fully ...

    Dual PI3K/mTOR inhibition is required to effectively impair microenvironment survival signals in mantle cell lymphoma 

    Rosich, Laia; Montraveta, Arnau; Xargay i Torrent, Sílvia; López-Guerra, Mónica; Roldán, Jocabed; Aymerich Gregorio, Marta; Salaverria Frigola, Itziar; Beà Bobet, Sílvia M.; Campo Güerri, Elias; Pérez Galán, Patricia; Roué, Gaël; Colomer Pujol, Dolors (Publication date: 2018-03-27)

    Phosphatidylinositol-3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway activation contributes to mantle cell lymphoma (MCL) pathogenesis and drug resistance. Antitumor activity has been observed with mTOR ...

    Genomic landscape of follicular lymphoma across a wide spectrum of clinical behaviors. 

    Mozas, Pablo; López González, Cristina; Grau Cuesta, Marta; Nadeu Prat, Ferran; Clot Razquin, Guillem; Valle, Sara; Kulis, Marta; Navarro López, Alba; Ramis Zaldivar, Joan Enric; González Farré. Blanca; Rivas Delgado, Alfredo; Rivero, Andrea; Frigola, Gerard; Balagué Ponz, Olga; Giné Soca, Eva; Delgado, Julio; Villamor i Casas, Neus; Matutes, Estella; Magnano, Laura; García Sanz, Ramón; Huet, Sarah; Russell. Robert B.; Campo Güerri, Elias; López Guillermo, Armando; Beà Bobet, Sílvia M. (Publication date: 2025-03-20)

    While some follicular lymphoma (FL) patients do not require treatment or experience prolonged responses, others relapse early, and little is known about genetic alterations specific to patients with a particular clinical ...

    A role for human Sp alpha as a pattern-recognition receptor 

    Sarrias Fornés, Maria Rosa; Roselló, Sandra; Sánchez-Barbero, Fernando; Sierra Ortigosa, Josep Maria; Vila Estapé, Jordi; Yélamos, José; Vives, Jordi; Casals, Cristina; Lozano Soto, Francisco (Publication date: 2021-05-03)

    Human Sp alpha is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily for which little functional information is available. It is expressed by macrophages present in lymphoid ...