Fonaments Clínics: Recent submissions
Now showing items 261-280 of 627
Genetic predisposition to chronic lymphocytic leukemia is mediated by a BMF super-enhancer polymorphism
Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which ...
Dissemination of NDM-producing Klebsiella pneumoniae and Escherichia coli high-risk clones in Catalan healthcare institutions
Objectives: To characterize the clonal spread of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli isolates between different healthcare institutions in Catalonia, Spain. Methods: Antimicrobial susceptibility ...
Predictive model for atrial fibrillation in hypertensive diabetic patients
Background: Several scores to identify patients at high risk of suffering atrial fibrillation have been developed. Their applicability in hypertensive diabetic patients, however, remains uncertain. Our aim is to develop ...
Validating a common tick survey method: cloth-dragging and line transects
Cloth-dragging is the most widely-used method for collecting and counting ticks, but there are few studies of its reliability. By using cloth-dragging, we applied a replicated line transects survey method, in two areas in ...
Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia.
Chronic lymphocytic leukemia (CLL) patients with differentialsomatic hypermutation status of the immunoglobulin heavy vari-able genes, namely mutated or unmutated, display fundamentalclinico-biological differences. Considering ...
Trends in Transmission of Drug Resistance and Prevalence of Non-B Subtypes in Patients with Acute or Recent HIV-1 Infection in Barcelona in the Last 16 Years (1997-2012)
OBJECTIVES: To evaluate the prevalence of transmitted drug resistance (TDR) and non-B subtypes in patients with acute/recent HIV-1 infection in Barcelona during the period ...
Virtuelles 3D Modell der Lendenwirbelsäule
Dieses interaktive Model entsprang einer 3D Nachbildung einer Kernspinaufnahme.
A Non-Inferiority, Individually Randomized Trial of Intermittent Screening and Treatment versus Intermittent Preventive Treatment in the Control of Malaria in Pregnancy
BACKGROUND: The efficacy of intermittent preventive treatment for malaria with sulfadoxine-pyrimethamine (IPTp-SP) in pregnancy is threatened in parts of Africa by the emergence and ...
Assessing viral metagenomics for the diagnosis of acute undifferentiated fever in returned travellers: a multicenter cohort study
Background: Up to 45% of febrile returning travellers remain undiagnosed after a thorough diagnostic work-up, even at referral centres. Although metagenomic next-generation sequencing (mNGS) has emerged as a promising tool, ...
Stromal markers of activated tumor associated fibroblasts predict poor survival and are associated with necrosis in non-small cell lung cancer
Objectives: Tumor associated fibroblasts (TAFs) are essential contributors of the progression of non-small cell lung cancer (NSCLC). Most lung TAFs exhibit an activated phenotype characterized by the expression of α-SMA ...
Perception and knowledge of the effect of climate change on infectious diseases within the general public: A multinational cross-sectional survey-based study
Infectious diseases are emerging and re-emerging due to climate change. Understanding how climate variability affects the transmission of infectious diseases is important for both researchers and the general public. Yet, ...
Core indicators evaluation of effectiveness of HIV-AIDS preventive-control programmnes carried out by nongovernmental organitations. A mixed method study
Background: The number of nongovernmental organizations working on AIDS has grown. There is great diversity in the type of activities and population groups that have been targeted. The purposes of this study are: to describe ...
Resistències als principals fàrmacs antituberculosos, importància, detecció i alteracions genètiques associades.
Anualment es declaren de vuit a nou milions de casos de tuberculosi al món, amb gairebé dos milions de morts. El 10% dels casos són resistents a algun dels fàrmacs. Diferents factors influeixen en les resistències, com el ...
Mastopatía fibroquística
La malaltia fibroquística de la mamella o mastopatia fibroquística és un terme vague que pretén definir clínicament una síndrome constituïda per una nodularitat mamària palpable poc delimitada, d'extensió diversa, freqüentment ...
Neurotoxic/Neuroprotective Effects of Clozapine and the Positive Allosteric Modulator of mGluR2 JNJ-46356479 in Human Neuroblastoma Cell Cultures
Current antipsychotics (APs) effectively control positive psychotic symptoms, mainly by blocking dopamine (DA) D2 receptors, but have little effect on negative and cognitive symptoms. Increased glutamate (GLU) release would ...
Emergence and spread of carbapenem-resistant Acinetobacter baumannii international clone II and III in Lima, Peru
Carbapenem-resistant Acinetobacter baumannii is the top-ranked pathogen in the World Health Organization priority list of antibiotic-resistant bacteria. It emerged as a global pathogen due to the successful expansion of a ...
Accurate Identification of ALK Positive Lung Carcinoma Patients: Novel FDA-Cleared Automated Fluorescence In Situ Hybridization Scanning System and Ultrasensitive Immunohistochemistry
Background: Based on the excellent results of the clinical trials with ALK-inhibitors, the importance of accurately identifying ALK positive lung cancer has never been greater. However, there are increasing number of recent ...
Factors Associated with Long-Term Sickness Absence Due to Mental Disorders: a Cohort Study of 7.112 Patients during the Spanish Economic Crisis
Background: Mental health problems are very common and often lead to prolonged sickness absence, having serious economic repercussions for most European countries. Periods of economic crisis are important social phenomena ...
Quality assurance in radiotherapy: analysis of the causes of not starting or early radiotherapy withdrawal.
BACKGROUND: The aim of this study was to analyse the reasons for not starting or for early of radiotherapy at the Radiation Oncology Department. METHODS: All radiotherapy treatments from March 2010 to February 2012 were ...
Humans shape the year-round distribution and habitat use of an opportunistic scavenger
Research focused on evaluating how human food subsidies influence the foraging ecology of scavenger species is scarce but essential for elucidating their role in shaping behavioral patterns, population dynamics, and potential ...
