Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 61-80 of 675
Total synthesis of lamellarin D and analogs library
Larnellarins are a group of marine natural products isolated from the prosobranch mollusc Lamellaria sp., the ascidian Didemnum sp., and the sponge Dendrilla Cactos. Several of them exhibit interesting biological activities. ...
Heteromeric nicotinic receptors are involved in the sensitization and addictive properties of MDMA in mice
We have investigated the effect of nicotinic receptor ligands in the behavioral sensitization (hyperlocomotion) and rewarding properties (conditioned place preference paradigm, CPP) of 3,4-methylenedioxy-methamphetamine ...
New fluorogenic probes for neutral and alkaline ceramidases
New fluorogenic ceramidase substrates derived from the N-acyl modification of our previously reported probes (RBM14) are reported. While none of the new probes were superior to the known RBM14C12 as acid ceramidase substrates, ...
Removal of the chiral inductor from phenylglycinol-derived tricyclic lactams. Unexpected generation of chiral trans-hydrochromene lactones
In the search for synthetic routes for the preparation of cis- and trans- decahydroquinolin-2- ones, a procedure for the generation of enantiopure trans-hydrochromene lactones, by treatment of (R)- phenylglycinol-derived ...
Fructose, but not glucose, impairs insulin signaling in the three major insulin-sensitive tissues
Human studies support the relationship between high intake of fructose-sweetened beverages and type 2 diabetes, but there is a debate on whether this effect is fructose-specific or it is merely associated to an excessive ...
Tissue Compatibility of SN-38-Loaded Anticancer Nanofiber Matrices
Delivery of chemotherapy in the surgical bed has shown preclinical activity to control cancer progression upon subtotal resection of pediatric solid tumors, but whether this new treatment is safe for tumor‐adjacent healthy ...
Alcoholisme: un cas clínic d'abordatge multidisciplinar a la Facultat de Farmàcia
Podeu consultar la Setena trobada de professorat de Ciències de la Salut completa a: http://hdl.handle.net/2445/43352
Enantioselective formal synthesis of ent-rhynchophylline and ent-isorhynchophylline
Starting from (S)-tryptophanol, a formal synthesis of ent-rhyncho-phylline and ent-isorhynchophylline, involving stereoselective cyclocondensation, spirocyclization, and alkylation reactions, and the final adjustment of ...
A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors
The development of multitarget compounds against multifactorial diseases, such as Alzheimer's disease, is an area of very intensive research, due to the expected superior therapeutic efficacy that should arise from the ...
Inhibition of 11β-HSD1, a key enzyme in the stress management, improves cognition by RL-118 drug treatment
In recent years, stress and stress-coping mechanisms constitute a growing public healthcare issue concerning modern society. Experiencing stress engenders a great complex mechanism named stress response, which consists of ...
Ethnopharmacological and chemical characterization of Salvia species used in Valencian traditional herbal preparations
In Valencia Region (Spain), some wild and cultivated sages are used for medicinal purposes. Among them, Salvia officinalis subsp. lavandulifolia (SL) is widely employed and known for production of Spanish sage oil and ...
Phosphoenolpyruvate from Glycolysis and PEPCK Regulate Cancer Cell Fate by Altering Cytosolic Ca2+
Changes in phosphoenolpyruvate (PEP) concentrations secondary to variations in glucose availability can regulate calcium signaling in T cells as this metabolite potently inhibits the sarcoplasmic reticulum Ca2+/ATPase pump ...
Sexual communication in day-flying Lepidoptera with special reference to castniids or 'butterfly-moths'
Butterflies and moths are subject to different evolutionary pressures that affect several aspects of their behaviour and physiology, particularly sexual communication. Butterflies are day-flying insects (excluding hedylids) ...
Acciones de mejora de las competencias profesionales de los estudiantes del Grado de Farmacia de la Universidad de Barcelona
El equipo decanal de la Facultad de Farmacia de la Universidad de Barcelona tiene como una de sus prioridades implementar acciones para la mejora de las competencias profesionales de los estudiantes del Grado de Farmacia. ...
Nanostructured materials for photodynamic therapy: synthesis, characterization and in vitro activity
Three nanostructured vehicles are proposed as potential carriers for photosensitizers to be used in photodynamic therapy: spherical nanoparticles, hexahedral microparticles and cylindrical magnetic nanorods. A comparative ...
Sex differences in the antidepressant-like response and molecular events induced by the imidazoline-2 receptor agonist CR4056 in rats
In searching for novel targets to design antidepressants, among the characterized imidazoline receptors (IR), I2 receptors are an innovative therapeutical approach since they are dysregulated in major depressive disorder ...
Isocyanides as Acceptor Groups in MHAT Reactions with Unactivated Alkenes
The use of isocyanides as acceptor groups in metal–hydride hydrogen atom transfer (MHAT) coupling reactions with nonactivated alkenes to form heterocycles is described. Monosubstituted alkenes couple and cyclize directly, ...
Pràcticas en empresa "lecciones aprendidas"
En este trabajo se analizan los resultados derivados de las encuestas recogidas de los estudiantes y de las empresas colaboradoras para el primer semestre del curso 14/15 (68 estudiantes de 72 matriculados). El objetivo ...
Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis
Multitarget anti-Alzheimer agents are the focus of very intensive research. Through a comprehensive bibliometric analysis of the publications in the period 1990-2020, we have identified trends and potential gaps that might ...
Synthesis of triheptanoin and formulation as a solid diet for rodents
Triheptanoin-enriched diets have been successfully used in the experimental treatment of various metabolic disorders. Maximal therapeutic effect is achieved in the context of a ketogenic diet where triheptanoin oil provides ...
