Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 181-200 of 675
El ácido bempedoico como activador PPARalpha: nuevas perspectivas para el tratamiento de la esteatosis hepática en un modelo experimental de rata hembra
La enfermedad del hígado graso no alcohólico cursa, en sus fases iniciales, con hipertrigliceridemia y acúmulo de lípidos en el hígado (esteatosis hepática). El ácido bempedoico es un inhibidor de la ATP:citrato liasa que ...
Cytotoxic Assessment of 3,3-Dichloro-β-Lactams Prepared through Microwave-Assisted Benzylic C-H Activation from Benzyl-Tethered Trichloroacetamides Catalyzed by RuCl2(PPh3)3
Natural and synthetic ß -lactam derivatives constitute an interesting class of compounds due to their diverse biological activity. Mostly used as antibiotics, they were also found to have antitubercular, anticancer and ...
Optimization of the spontaneous tail coiling test for fast assessment of neurotoxic effects in the zebrafish embryo using an automated workflow in KNIME®
Neuroactive chemicals are frequently detected in the environment. At sufficiently high concentrations or within mixtures, they could provoke neurotoxic effects and neurological diseases to organisms and humans. Fast ...
Cyclocondensation reactions of 2-acyl-3-indoleacetic acid derivatives with phenylglycinol. Enantioselective synthesis of 1-substituted tetrahydro-b-carboline alkaloids
Cyclocondensation reactions between a variety of 2‐acyl‐3‐indoleacetic acid derivatives and (R )‐phenylglycinol were studied. Successful results were obtained from N ‐alkyl keto acid derivatives. The resulting tetracyclic ...
Recent advances in lamellarin alkaloids: isolation, synthesis and activity
Lamellarins are a large family of marine alkaloids with potential anticancer activity that have been isolated from diverse marine organisms, mainly ascidians and sponges. All lamellarins feature a 3,4-diarylpyrrole system. ...
Effects of Nutrition on Cognitive Function in Adults with or without Cognitive Impairment: A Systematic Review of Randomized Controlled Clinical Trials
New dietary approaches for the prevention of cognitive impairment are being investigated. However, evidence from dietary interventions is mainly from food and nutrient supplement interventions, with inconsistent results ...
Developmental exposure to MDMA (ecstasy) in zebrafish embryos reproduces the neurotoxicity adverse outcome 'lower motor activity' described in humans
The recreational use of MDMA (ecstasy) by pregnant women is associated with impaired neuromotor function in infants, but the Adverse Outcome Pathway behind this effect is not clear yet. We present for the first time the ...
Facile synthesis of azocino[4,3-b]indoles by ring-closing metathesis
The azocino[4,3-b]indole system, tricyclic substructure of the indole alkaloids apparicine and ervaticine, is efficiently assembled by ring-closing metathesis of 2-allyl-3-(allylaminomethyl)indoles. The metathesis sites ...
<strong>Assessment of Endocrine-Disrupting Properties in Cosmetic Ingredients: Focus on UV Filters and Alternative Testing Methods</strong>
Endocrine-disrupting chemicals are substances capable of interfering with hormonal systems, potentially leading to adverse developmental, reproductive, neurological, and immune effects in both humans and wildlife. Various ...
Enantioselective formal synthesis of (+)-madangamine A
An enantioselective formal synthesis of the marine alkaloid madangamine A using phenylglycinol-derived lactam 1 as the starting enantiomeric scaffold is reported. The synthesis involves the construction of the C-9 substituted ...
A Joint experimental-computational comparative study of the Pd(0)-catalysed reactions of aryl iodides and aldehydes with N, O, and S tethers
The influence of the heteroatom (nitrogen, oxygen, and sulfur) on the course of the palladium‐catalysed intramolecular reactions of aryl iodides and aldehydes having heteroatom‐containing tethers has been explored by an ...
Species-specific developmental toxicity in rats and rabbits: generation of a reference compound list for development of alternative testing approaches
For regulatory information requirements, developmental toxicity testing is often conducted in two mammalian species. In order to provide a set of reference compounds that could be used to explore alternative approaches to ...
Pharmacological Inhibition of Soluble Epoxide Hydrolase as a New Therapy for Alzheimer's Disease
The inhibition of the enzyme soluble epoxide hydrolase (sEH) has demonstrated clinical therapeutic effects in several peripheral inflammatory-related diseases, with three compounds in clinical trials. However, the role of ...
Electrophysiological and behavioral responses of the black-banded oak borer Coroebus florentinus to conspecific insect and host plant volatiles
Aspects of the chemical ecology of the black-banded oak borer, (BBOB) Coroebus florentinus (Coleoptera: Buprestidae), were studied. Odors produced by males and females were similar, both qualitatively and quantitatively. ...
Inhibition of 11β-HSD1 Ameliorates Cognition and Molecular Detrimental Changes after Chronic Mild Stress in SAMP8 Mice
Impaired glucocorticoid (GC) signaling is a significant factor in aging, stress, and neurodegenerative diseases such as Alzheimer's disease. Therefore, the study of GC-mediated stress responses to chronic moderately stressful ...
Synthesis of phenylalaninol-derived oxazolopyrrolidone lactams and evaluation as NMDA receptor antagonists
N-Methyl-D-aspartate (NMDA) receptor antagonists are known to rescue neuronal cell death caused by excessive activation of glutamate receptors. This phenomenon, known as excitotoxicity, is implicated in the pathogenesis ...
Algunes notes sobre la producció científica empordanesa
Quan hom intenta de fer una valoració d'allò que ha estat o és la producció cultural en un determinat àmbit geogràfic, és del tot pertinent -i necessari- de dedicar un espai a una faceta d'aquest afer que ben sovint és ...
In vitro studies on the tumorigenic potential of the halonitromethanes trichloronitromethane and bromonitromethane
Epidemiological data indicate that chronic exposure to water disinfection by-products (DBPs) may result in increased risk of cancer. However, the real carcinogenic potential of individual DBPs is not well known. In this ...
Sequential ring-closing metathesis-vinyl halide Heck cyclization reactions: access to the tetracyclic ring system of ervitsine
A chemoselective indole-templated ring-closing metathesis is used to assemble the cyclohepta[b]indole substructure of the indole alkaloid ervitsine. A subsequent intramolecular Heck coupling of the resulting alkene ...
Preparation and Double Michael Addition Reactions of a Synthetic Equivalent of Nazarov Reagent
A synthetic equivalent of the Nazarov reagent, the silyl derivative 2, able to undergo base-catalyzed double Michael addition reactions with a,b-unsaturated carbonyl compounds, has been developed. The new reagent satisfactorily ...
