Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 201-220 of 675
Aplicació terapèutica dels compostos organometal·lics
In recent years, organometallic chemistry has acquired an important role in clinical practice, although it exists a wide variety of organic structures linked to metals in nature, and involved in biological processes. The ...
Polypurine Reverse Hoogsteen Hairpins as a tool for gene repair and editing
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/120717
Trafficking of Gold Nanoparticles Coated with the 8D3 Anti-Transferrin Receptor Antibody at the Mouse Blood-Brain Barrier
Receptor-mediated transcytosis has been widely studied as a possible strategy to transport neurotherapeutics across the blood-brain barrier (BBB). Monoclonal antibodies directed against the transferrin receptor (TfR) have ...
Tetrasubstituted imidazolium salts as potent antiparasitic agents against African and American trypanosomiases
Imidazolium salts are privileged compounds in organic chemistry, and have valuable biological properties. Recent studies show that symmetric imidazolium salts with bulky moieties can display antiparasitic activity against ...
Dendritic Spine Abnormalities in Hippocampal CA1 Pyramidal Neurons Underlying Memory Deficits in the SAMP8 Mouse Model of Alzheimer's Disease
SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the focus of attention as they show several alterations that have also been described in Alzheimer"s disease (AD) patients. The number ...
Determinació de la tolerància gastro-intestinal de medicaments mitjançant la quantificació radioactiva de les microhemorràgies digestives
Les lesions gastro-intestinals (GI) són, probablement, un deis principals efectes secundaris de l'ús dels antiinflamatoris i de molts altres agents terapèutics. Malgrat que els mecanismes productors de les lesions no són ...
Liquid fructose downregulates SIRT1 expression and activity and impairs the oxidation of fatty acids in rat and human liver cells
Fructose ingestion is associated with the production of hepatic steatosis and hypertriglyceridemia. For fructose to attain these effects in rats, simultaneous induction of fatty acid synthesis and inhibition of fatty acid ...
Amino acid-protecting groups
Synthetic organic chemistry is based on the concourse of reagents and catalysts to achieve the clean formation of new bonds and appropriate protecting groups are required to prevent the formation of undesired bonds and ...
Statins Inhibit HIV-1 Infection by Down-regulating Rho Activity
Human immunodeficiency virus (HIV)-1 infectivity requires actin-dependent clustering of host lipid raft-associated receptors, a process that might be linked to Rho guanosine triphosphatase (GTPase) activation. Rho GTPase ...
La Fitoterapia hoy: evidencias
II Congreso de Alimentación, Nutrición y Dietética. Avances en Nutrición y Dietética Clínica: Prevención, Tratamiento y Gestión - Rol del Dietista-Nutricionista
Chronic liquid fructose, but not glucose, supplementation selectively induces visceral adipose tissue leptin resistance and hypeertrophy in female Sprague-Dawley rats
Scope: The effect of chronic supplementation with simple-sugar solutions on leptin signaling in liver, hypothalamus, and visceral white adipose tissue (vWAT) is studied, which is designed to mimic the temporal pattern of ...
Magnetic nanoparticles: From diagnosis to therapy
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/128014
Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
Methylone is a cathinone derivative that has recently emerged as a designer drug of abuse in Europe and the USA. Studies on the acute and long-term neurotoxicity of cathinones are starting to be conducted. We investigated ...
Cardiovascular effects of PCB 126 (3,3',4,4',5-pentachlorobiphenyl) in zebrafish embryos and impact of co-exposure to redox modulating chemicals
The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the cardiovascular ...
Comparison of Migration Disturbance Potency of Epigallocatechin Gallate (EGCG) Synthetic Analogs and EGCG PEGylated PLGA Nanoparticles in Rat Neurospheres
Epigallocatechin gallate (EGCG), the main catechin of green tea, is described to have potential health benefits in several fields like oncology, neurology or cardiology. Currently, it is also under pre-clinical investigation ...
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease
Alzheimer's disease (AD), the most common type of dementia, currently represents an extremely challenging and unmet medical need worldwide. Amyloid-β (Aβ) and Tau proteins are prototypical AD hallmarks, as well as validated ...
Development of a strategy for the administration of praziquantel to the terrestrial edible snail Cornu aspersum parasitized by Brachylaima sp. metacercariae
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/120717
Editorial: Epigenetic Mechanisms Regulating Neural Plasticity.
While larger parts of the genome have been deciphered and sequenced during the last decade, it is now possible to identify practically all the genes that a cell or tissue transcribes and translates at a given moment in ...
Effects of maternal fructose intake on perinatal ER-Stress: A defective XBP1s nuclear translocation affects the ER-stress resolution
Endoplasmic reticulum (ER) homeostasis is crucial to appropriate cell functioning, and when disturbed, a safeguard system called unfolded protein response (UPR) is activated. Fructose consumption modifies ER homeostasis ...
Review of Drug Storage Conditions, A Case Report
High temperatures during the summer season are a very important factor to be considered due to their possible influence on drug stability and effectiveness. This is especially important in those patients included in clinical ...
