Farmacologia, Toxicologia i Química Terapèutica: Enviaments recents
Ara mostrant els elements 301-320 de 675
Disturbances in metabolic, transport and structural genes in experimental colonic inflammation in the rat: a longitudinal genomic analysis
Background: Trinitrobenzenesulphonic acid (TNBS) induced rat colitis is one of the most widely used models of inflammatory bowel disease (IBD), a condition whose aetiology and pathophysiology are incompletely understood. ...
Editorial: Epigenetic Mechanisms Regulating Neural Plasticity.
While larger parts of the genome have been deciphered and sequenced during the last decade, it is now possible to identify practically all the genes that a cell or tissue transcribes and translates at a given moment in ...
Effects of maternal fructose intake on perinatal ER-Stress: A defective XBP1s nuclear translocation affects the ER-stress resolution
Endoplasmic reticulum (ER) homeostasis is crucial to appropriate cell functioning, and when disturbed, a safeguard system called unfolded protein response (UPR) is activated. Fructose consumption modifies ER homeostasis ...
«Pasaporte a la profesión» en el grado de Farmacia: análisis y valoración del periodo 2015-2023
INTRODUCCIÓ. Des del 2015, la Facultat de Farmàcia i Ciències de l’Alimentació de la Universitat de Barcelona implementa el programa «Passaport a la professió» per vincular la formació acadèmica dels estudiants del grau ...
Review of Drug Storage Conditions, A Case Report
High temperatures during the summer season are a very important factor to be considered due to their possible influence on drug stability and effectiveness. This is especially important in those patients included in clinical ...
Cardiovascular effects of PCB 126 (3,3',4,4',5-pentachlorobiphenyl) in zebrafish embryos and impact of co-exposure to redox modulating chemicals
The developing cardiovascular system of zebrafish is a sensitive target for many environmental pollutants, including dioxin-like compounds and pesticides. Some polychlorinated biphenyls (PCBs) can compromise the cardiovascular ...
Total Synthesis of the Brdged Indole Alkaloid Apparicine
An indole-templated ring-closing metathesis or a 2-indolylacyl radical cyclization constitute the central steps of two alternative approaches developed to assemble the tricyclic ABC substructure of the indole alkaloid ...
Development of a strategy for the administration of praziquantel to the terrestrial edible snail Cornu aspersum parasitized by Brachylaima sp. metacercariae
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/120717
Clock/Sleep-Dependent Learning and Memory in Male 3xTg-AD Mice at Advanced Disease Stages and Extrinsic Effects of Huprine X and the Novel Multitarget Agent AVCRI104P3
A new hypothesis highlights sleep-dependent learning/memory consolidation and regards the sleep-wake cycle as a modulator of beta-amyloid and tau Alzheimer's disease (AD) pathologies. Sundowning behavior is a common ...
Serotonergic impairment and memory deficits in adolescent rats after binge exposure of methylone
Methylone is a cathinone derivative that has recently emerged as a designer drug of abuse in Europe and the USA. Studies on the acute and long-term neurotoxicity of cathinones are starting to be conducted. We investigated ...
Discovery of Dual Aβ/Tau Inhibitors and Evaluation of Their Therapeutic Effect on a Drosophila Model of Alzheimer's Disease
Alzheimer's disease (AD), the most common type of dementia, currently represents an extremely challenging and unmet medical need worldwide. Amyloid-β (Aβ) and Tau proteins are prototypical AD hallmarks, as well as validated ...
Structure-activity relationships of serotonergic 5-MeO-DMT derivatives: insights into psychoactive and thermoregulatory properties
<span style="color:rgb( 33 , 33 , 33 )">Recent studies have sparked renewed interest in the therapeutic potential of psychedelics for treating depression and other mental health conditions. Simultaneously, the novel ...
7,8-Dihydroxyflavone blocks the development of behavioral sensitization to MDPV, but not to cocaine: Differential role of the BDNF-TrkB pathway
3,4-Methylenedioxypyrovalerone (MDPV) acts as a dopamine transporter blocker and exerts powerful psychostimulant effects. In this study we aimed to investigate the bidirectional cross-sensitization between MDPV and cocaine, ...
Medicinal and food plants in ethnobotany and ethnopharmacology: Folk functional foods in Catalonia (Iberian Peninsula)
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/120717
Use of Natural Polymers for the Encapsulation of Eugenol by Spray Drying
<strong>Background:</strong> Eugenol is a colourless or yellowish compound whose presence in clove essential oil surpasses the 75% of its composition. This phenylpropanoid, widely used as an antiseptic, anaesthetic and ...
Intercalative DNA binding of the marine anticancer drug variolin B
Variolin B is a rare marine alkaloid that showed promising anti-cancer activity soon after its isolation. It acts as a cyclin-dependent kinase inhibitor, although the precise mechanism through which it exerts the cytotoxic ...
Supramolecular and base-induced singlet oxygen generation enhancement of a water-soluble phthalocyanine
Investigation into the reactive oxygen species (ROS) generating abilities of photosensitizers outside of in-vitro/vivo conditions is a crucial element in the wider study of photodynamic therapy (PDT) in clinical settings. ...
Synthesis and antitumor activity of mechercharmycin A analogues
Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines. Thiopeptide ...
Access to Enantiopure 5‑, 7‑, and 5,7-Substituted cis- Decahydroquinolines: Enantioselective Synthesis of (−)-Cermizine B
Stereoconvergent cyclocondensation reactions of (R)- or (S)-phenylglycinol with appropriately substituted cyclohexanone-based δ-keto esters are the key steps of short synthetic routes to enantiopure 5-, 7-, and 5,7-substituted ...
