Bioquímica i Biomedicina Molecular: Recent submissions
Now showing items 81-100 of 917
Complexes of Pd(II) and Pt(II) with 9-aminoacridine: reactions with DNA and study of their antiproliferative activity
Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the ...
El carboni, l'esquelet de la vida
El carboni va esdevenir, fa més de tres mil cinc-cents milions d'anys, l'element bàsic sobre el qual es va generar la vida a la Terra. Per què? Quines característiques el van fer tan especial? D'on va sortir el carboni ...
S-acylation-dependent membrane microdomain localization of the regulatory Kvβ2.1 subunit
The voltage-dependent potassium (Kv) channel Kvβ family was the frst identifed group of modulators of Kv channels. Kvβ regulation of the α-subunits, in addition to their aldoketoreductase activity, has been under extensive ...
Estudi del comportament i regulació de l'enzim de la sintesi de glicogen en trombòcits humans
El glucogen ha estat descrit cons a component inajoritari clefs tromhocits. La seva ftfltcio coin a reserva energetica dins la ccllula sembla esser operativa en el netabolisme del trombocit i en la seva fancies fisiolugica. ...
Effect of cancer-related cachexia and related changes in nutritional status, inflammatory status, and muscle mass on immunotherapy efficacy and survival in patients with advanced non-small cell lung cancer
Immune checkpoint inhibitor (ICI)-based immunotherapy has significantly improved the survival of patients with advanced non-small cell lung cancer (NSCLC); however, a significant percentage of patients do not benefit from ...
Moderate calorie restriction during gestation programs offspring for lower BAT thermogenic capacity driven by thyroid and sympathetic signaling
BACKGROUND: Maternal calorie restriction during pregnancy programs offspring for later overweight and metabolic disturbances.Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis and has recently emerged ...
BIGNASim: A NoSQL database structure and analysis portal for nucleic acids simulation data
Molecular dynamics simulation (MD) is, just behind genomics, the bioinformatics tool that generates the largest amounts of data, and that is using the largest amount of CPU time in supercomputing centres. MD trajectories ...
Alanine aminotransferase: A target to improve utilisation of dietary nutrients in aquaculture
Podeu consultar el llibre complet a: http://hdl.handle.net/2445/67430
Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist
Several recent studies suggest functional and molecular interactions between striatal adenosine A2A and cannabinoid CB1 receptors. Here, we demonstrate that A2A receptors selectively modulate reinforcing effects of ...
El futur dels cursos massius oberts en línia
El MOOC són cursos en línia d'accés obert a través d'internet, dirigits a un nombre il·limitat de participants. Vídeos, exercicis i altre material encapsulat que es pot seguir des de qualsevol ordinador o tauleta. Una ...
Molecular dynamics modelling of the interaction of a synthetic zinc-finger miniprotein with DNA
We report the modelling of the DNA complex of an artificial miniprotein composed of two zinc finger modules and an AT-hook linking peptide. The computational study provides for the first time a structural view of these ...
Dinamitzar sectors d'alt valor afegit evitarà crisis
Segons dades de Biocat, Catalunya té el 21% de les empreses del sector biotecnològic espanyol que mouen més de 15.000 milions d'euros i ocupen més de 22.000 persones. A final del 2011, en el sector hi constaven 1.156 ...
Analysis of autophagic vesicles in mitotic cells
The detection of autophagic vesicles in interphase cells is well characterized with markers such as LC3, SQSTM1 (also known as p62) and LAMP2, which are commonly used in immunofluorescence and biochemistry assays to evaluate ...
Short-term oleoyl-estrone treatment affects capacity to manage lipids in rat adipose tissue
Background: Short-term OE (oleoyl-estrone) treatment causes significant decreases in rat weight mainly due to adipose tissue loss. The aim of this work was to determine if OE treatment affects the expression of genes that ...
Zebrafish models for human acute organophosphorus poisoning
Terrorist use of organophosphorus-based nerve agents and toxic industrial chemicals against civilian populations constitutes a real threat, as demonstrated by the terrorist attacks in Japan in the 1990 s or, even more ...
GDF15 mediates the metabolic effects of PPARβ/δ by activating AMPK
Peroxisome proliferator-activated receptor β/ (PPARβ/) activates AMP-activated protein kinase (AMPK) and plays a crucial role in glucose and lipid metabolism. Here, we examined whether the beneficial effects of PPARβ/δ ...
Cafeteria diet induce changes in blood flow that are more related with heat dissipation than energy accretion
Podeu consultar dades primàries associades a l'article a: http://hdl.handle.net/2445/96861
Fibroblast growth factor 21 in breast milk controls neonatal intestine function
FGF21 is a hormonal factor with important functions in the control of metabolism. FGF21 is found in rodent and human milk. Radiolabeled FGF21 administered to lactating dams accumulates in milk and is transferred to neonatal ...
Innovació: alerta roja
Les dades sobre l'Estat espanyol són dolentes, tant és així que, en referir-s'hi, la pàgina de resum titula: '«Aggravating decline: Spain»'. S'observa un descens de gairebé el 20% del pressupost públic en termes absoluts ...
Regulation of human class I alcohol dehydrogenases by bile acids
Class I alcohol dehydrogenases (ADH1s) are the rate-limiting enzymes for ethanol and vitamin A (retinol) metabolism in the liver . Because previous studies have shown that human ADH1 enzymes may participate in bile acid ...
