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Biomedicina: Envíos recientes

Mostrando ítems 521-540 de 779

    Impact of Region-of-Interest Delineation Methods, Reconstruction Algorithms, and Intra- and Inter-Operator Variability on Internal Dosimetry Estimates Using PET 

    López Vilanova, N.; Pavía Segura, Javier; Duch Guillén, Ma. Amor (María Amor); Catafau Alcántara, Ana Ma.; Ros Puig, Domènec; Bullich Roig, Santiago (Fecha de publicación: 2019-02-05)

    Purpose: Human dosimetry studies play a central role in radioligand development for positron emission tomography (PET). Drawing regions of interest (ROIs) on the PET images is used to measure the dose in each organ. In the ...

    HER-2/AKT expression in upper urinary tract urothelial carcinoma: prognostic implications 

    Izquierdo Reyes, Laura; Truan, David; Mengual Brichs, Lourdes; Mallofré i Gómez, Carme; Alcaraz Asensio, Antonio (Fecha de publicación: 2019-04-09)

    AIM: To assess HER-2 and p-AKT expression in upper urinary tract urothelial carcinoma (UTUC) in order to determine their value as prognostic factors of tumour progression and cancer-specific survival. PATIENTS AND METHODS: ...

    Cryopreservation of Human Pluripotent Stem Cells: Are We Going in the Right Direction? 

    Martín Ibáñez, Raquel; Hovatta, Outi; Canals i Coll, Josep M. (Fecha de publicación: 2021-03-09)

    The first derivation of human embryonic stem cells (hESCs) (Thomson et al., 1998) and the more recently development of human induced pluripotent stem cells (iPSCs) (Park et al., 2008; Takahashi et al., 2007; Takahashi & ...

    RTP801 interacts with the tRNA ligase complex and dysregulates its RNA ligase activity in Alzheimer's disease 

    Campoy Campos, Genís; Solana Balaguer, Júlia; Guisado Corcoll, Anna; Chicote González, Almudena; García Segura, Pol; Pérez Sisqués, Leticia; Gabriel Torres, Adrián; Canal de la Iglesia, Mercè; Molina Porcel, Laura; Fernández Irigoyen, Joaquín; Santamaría, Enrique; Ribas de Pouplana, Lluís; Alberch i Vié, Jordi, 1959-; Martí Puig, Eulàlia; Giralt Torroella, Albert; Pérez Navarro, Esther; Malagelada Grau, Cristina (Fecha de publicación: 2025-08-27)

    RTP801/REDD1 is a stress-responsive protein overexpressed in neurodegenerative diseases such as Alzheimer’s disease (AD) that contributes to cognitive deficits and neuroinflammation. Here, we found that RTP801 interacts ...

    Helios modulates the maturation of a CA1 neuronal subpopulation required for spatial memory formation 

    Giralt Torroella, Albert; Brito, Verónica; Pardo Muñoz, Mònica; Rubio Abejón, Sara Esmeralda; Marion Poll, Lucile; Martín Ibáñez, Raquel; Zamora-Moratalla, Alfonsa; Bosch, Carles; Ballesteros, Jesús J.; Blasco, Esther; García-Torralba, Aída; Pascual Sánchez, Marta; Pumarola, Martí; Alberch i Vié, Jordi, 1959-; Ginés Padrós, Silvia; Martín, Eduardo D.; Segovia, José Carlos; Soriano García, Eduardo; Canals i Coll, Josep M. (Fecha de publicación: 2020-03-26)

    Currently, molecular, electrophysiological and structural studies delineate several neural subtypes in the hippocampus. However, the precise developmental mechanisms that lead to this diversity are still unknown. Here we ...

    Lung Tissue Multilayer Network Analysis Uncovers the Molecular Heterogeneity of Chronic Obstructive Pulmonary Disease 

    Olvera Ocaña, Núria; Sánchez Valle, Jon; Núñez Carpintero, Iker; Rojas Quintero, Joselyn; Noell, Guillaume; Casas Recasens, Sandra; Faiz, Alen; Hansbro, Philip M.; Guirao Montes, Àngela; Lepore, Rosalba; Cirillo, Davide; Agustí García-Navarro, Àlvar; Polverino, Francesca; Valencia, Alfonso; Faner, Rosa (Fecha de publicación: 2025-01-07)

    Rationale: Chronic obstructive pulmonary disease (COPD) is a heterogeneous condition. Objectives: We hypothesized that the unbiased integration of different COPD lung omics using a novel multilayer approach might unravel ...

    Liver-targeted nanoparticles delivering nitric oxide reduce portal hypertension in cirrhotic rats 

    Perramón Corominas, Meritxell; Navalón López, María; Fernández Varo, Guillermo; Moreno Lanceta, Alazne; García Pérez, Rocío; Faneca, Joana; López Moya, Mario; Fornaguera, Cristina; García Villoria, Judit; Morales Ruiz, Manuel; Melgar-Lesmes, Pedro; Borrós, Salvador; Jiménez Povedano, Wladimiro (Fecha de publicación: 2025-07-09)

    Nitric oxide (NO) is a small vasodilator playing a key role in the pathogenesis of portal hypertension. Here, we assessed the potential therapeutic effect of a NO donor targeted to the liver by poly(beta-amino ester) ...

    Hippocampal Pyk2 regulates specific social skills: Implications for schizophrenia 

    López Molina, Laura; Sancho Balsells, Anna; Al-Massadi, Omar; Montalban, Enrica; Alberch i Vié, Jordi, 1959-; Arranz, Belém; Girault, Jean-Antoine; Giralt Torroella, Albert (Fecha de publicación: 2025-07-09)

    Pyk2 has been shown previously to be involved in several psychological and cognitive alterations related to stress, Huntington's disease, and Alzheimer's disease. All these disorders are accompanied by different types of ...

    A role for human Sp alpha as a pattern-recognition receptor 

    Sarrias Fornés, Maria Rosa; Roselló, Sandra; Sánchez-Barbero, Fernando; Sierra Ortigosa, Josep Maria; Vila Estapé, Jordi; Yélamos, José; Vives, Jordi; Casals, Cristina; Lozano Soto, Francisco (Fecha de publicación: 2021-05-03)

    Human Sp alpha is a soluble protein belonging to group B of the scavenger receptor cysteine-rich (SRCR) superfamily for which little functional information is available. It is expressed by macrophages present in lymphoid ...

    Lamellarin D bioconjugates I: synthesis and cellular internalization of PEG-derivatives 

    Pla Queral, Daniel; Francesch, Andrés; Calvo, Pilar; Cuevas, Carmen; Aligué i Alemany, Rosa Maria; Albericio Palomera, Fernando; Álvarez Domingo, Mercedes (Fecha de publicación: 2014-07-18)

    Herein is reported the design and synthesis of poly(ethylene glycol) derivatives of Lamellarin D with the aim of modulating their physicochemical properties, and improving the biological activity. Mono-, di- and tri-PEG ...

    Effects of dietary cis/trans unsaturated and saturated fatty acids on the glucose metabolites and enzymes of rats. 

    Bernal, Claudio Adrian; Rovira, Jordi; Colandré, María E.; Cussó, Roser; Cadefau Surroca, Joan Aureli (Fecha de publicación: 2025-11-27)

    The aim of the present study was to examine whether the level of dietary cis fatty acid (cFA), or the isomers (trans or cis) and/or the saturation of the fatty acids at high dietary fat levels altered the intracellular ...

    Cortical thickness modeling and variability in Alzheimer's disease and frontotemporal dementia 

    Pérez Millan, Agnès; Borrego Écija, Sergi; Falgàs Martínez, Neus; Juncà Parella, Jordi; Bosch Capdevila, Beatriz; Tort Merino, Adrià; Antonell Boixader, Anna, 1978-; Bargalló Alabart, Núria; Rami González, Lorena; Balasa, Mircea; Lladó Plarrumaní, Albert; Sala Llonch, Roser; Sánchez Valle, Raquel (Fecha de publicación: 2024-02-13)

    Alzheimer's disease (AD) and frontotemporal dementia (FTD) show different patterns of cortical thickness (CTh) loss compared with healthy controls (HC), even though there is relevant heterogeneity between individuals ...

    Cell Differentiation Molecules (HCDM) organization. CD Molecules Nomenclature 2025: Antibody Validation and Expression Profiling of Immune System G Protein-Coupled Receptors. 

    Fernández Calles, Javier; Kuzilkova, Daniela; Hedin, Fanny; Bakardjieva Mihaylova, Violeta; Škvárová Kramarzová, Karolina; Zelm, Menno C. van; Cosma, Antonio; Kalina, Tomas; Engel Rocamora, Pablo (Fecha de publicación: 2026-02-24)

    Monoclonal antibodies (mAbs) targeting cell-surface molecules are pivotal in biomedical research, diagnostic applications, and biotechnology. Over the past four decades, the CD nomenclature system, established by the Human ...

    Andronet News. Winter 2024-2025 

    Laurentino, Sandra; Rajpert-De Meyts, Ewa (Fecha de publicación: 2025-11-11)

    This newsletter marks the beginning of the last year of our COST ANDRONET Action. That does not mean that we are slowing our efforts in bringing together the research community dealing with andrological issues, much ...

    A myriad of miRNA variants in control and Huntington's disease brain regions detected by massively parallel sequencing 

    Martí Puig, Eulàlia; Pantano, Lorena; Bañez-Coronel, Mónica; Llorens Torres, Franc; Miñones Moyano, Elena; Porta, Sílvia; Sumoy, Lauro; Ferrer, Isidro (Ferrer Abizanda); Estivill, Xavier, 1955- (Fecha de publicación: 2018-11-21)

    Huntington disease (HD) is a neurodegenerative disorder that predominantly affects neurons of the forebrain. We have applied the Illumina massively parallel sequencing to deeply analyze the small RNA populations of two ...

    An RORγt oral inhibitor modulates IL-17 responses in peripheral blood and intestinal mucosa of Crohn's disease patients 

    Bassolas Molina, Helena; Raymond, Ernest; Labadia, Mark; Wahle, Joseph; Ferrer Picón, Elena; Panzenbeck, Mark; Zheng, Jie; Harcken, Christian; Hughes, Robert; Turner, Michael; Smith, Dustin; Calderón-Gómez, Elisabeth; Esteller Viñal, Miriam; Carrasco García, Anna; Esteve i Comas, Maria; Dotti, Isabella; Corraliza Márquez, Ana Maria; Masamunt, Maria Carme; Arajol, Claudia; Guardiola, Jordi; Ricart, Elena; Nabozny, Gerald; Salas Martínez, Azucena (Fecha de publicación: 2019-10-02)

    Background and Aims: Despite the negative results of blocking IL-17 in Crohn's disease (CD) patients, selective modulation of Th17-dependent responses warrants further study. Inhibition of retinoic acid-related orphan ...

    Validity of prognostic models of critical COVID-19 is variable. A systematic review with external validation 

    Bosch de Basea, Magda; Cobo, Inés; Subirana Cachinero, Isaac; Ceresa, Mario; Famada, Ernest; Gimeno Santos, Elena, 1980-; Delgado-Ortiz, Laura; Faner, Rosa; Molina Molina, María; Agustí García-Navarro, Àlvar; Muñoz, Xavier; Sibila Vidal, Oriol; Gea Guiral, Joaquim; García Aymerich, Judith (Fecha de publicación: 2024-03-08)

    Objectives: To identify prognostic models which estimate the risk of critical COVID-19 in hospitalized patients and to assess their validation properties. Study design and setting: We conducted a systematic review in Medline ...

    Annexins-Coordinators of Cholesterol Homeostasis in Endocytic Pathways 

    Rentero Alfonso, Carles; Blanco Muñoz, Patricia; Meneses Salas, Elsa; Grewal, Thomas; Enrich Bastús, Carles (Fecha de publicación: 2020-04-20)

    The spatiotemporal regulation of calcium (Ca2+) storage in late endosomes (LE) and lysosomes (Lys) is increasingly recognized to influence a variety of membrane trafficking events, including endocytosis, exocytosis, and ...

    Role of p27Kip1 as a transcriptional regulator 

    Bachs Valldeneu, Oriol; Gallastegui Calvache, Edurne, 1982-; Orlando, Serena; Bigas Salvans, Anna; Morante Redolat, José Manuel; Serratosa i Serdà, Joan; Fariñas, Isabel; Aligué i Alemany, Rosa Maria; Pujol Sobrevía, María Jesús (Fecha de publicación: 2020-04-16)

    The protein p27Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase (Cdk) inhibitors. It interacts with both the catalytic and the regulatory subunit (cyclin) and introduces a region into the catalytic cleave ...

    Decreased and Heterogeneous Neutralizing Antibody Responses Against RBD of SARS-CoV-2 Variants After mRNA Vaccination. 

    Hernández Luis, Pablo; Aguilar, Ruth; Pelegrin Pérez, Judit; Ruiz Olalla, Gemma; García-Basteiro, Alberto L.; Tortajada, Marta; Moncunill Piñas, Gemma; Dobaño, Carlota, 1969-; Angulo Aguado, Ana; Engel Rocamora, Pablo (Fecha de publicación: 2023-04-26)

    The rapid spread of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) emerging variants raises concerns about their capacity to evade immune protection provided by natural infection or vaccination. The ...