Biomedicina: Enviaments recents
Ara mostrant els elements 541-560 de 779
AMPAR interacting protein CPT1C enhances surface expression of GluA1-containing receptors
AMPARs mediate the vast majority of fast excitatory synaptic transmission in the brain and their biophysical and trafficking properties depend on their subunit composition and on several posttranscriptional and posttranslational ...
Sertraline treatment prevents motor dysfunction in a Huntington's disease mouse model and functional decline in patients
Molecular alterations underlying Huntington's disease (HD) are not fully elucidated and no curative therapies are available. We have described that increased translation efficiency participates in the motor symptoms in the ...
Novel truncating germline variant reinforces TINF2 as a susceptibility gene for familial non-medullary thyroid cancer
Background: It has long been observed that there are families in which non-medullary thyroid cancer (NMTC) occurs, but few syndromes and genes have been described to date. Proteins in the shelterin complex have been implied ...
The contribution of human sperm proteins to the development and epigenome of the preimplantation embryo.
BACKGROUND: Knowledge of the proteomic composition of the gametes is essential to understand reproductive functions. Most of the sperm proteins are related to spermatogenesis and sperm function, but less abundant protein ...
Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux
Caveolin-1 (Cav1), a structural protein required for the formation of invaginated membrane domains known as caveolae, has been implicated in cholesterol trafficking and homeostasis. Here we investigated the contribution ...
Calmodulin inhibitor W13 induces sustained activation of ERK2 and expression of p21CIP1
One of the major signaling pathways by which extracellular signals induce cell proliferation and differentiation involves the activation of extracellular signal-regulated kinases (ERKs). Because calmodulin is essential for ...
Cell compression - relevance, mechanotransduction mechanisms and tools
From border cell migration during Drosophila embryogenesis to solid stresses inside tumors, cells are often compressed during physiological and pathological processes, triggering major cell responses. Cell compression can ...
Andronet. Winter 2023/2024
After a nice Holiday Season at the end of 2023, we are now looking forward to new activities in the spring. Note that ANDRONET will support several short-term scientific visits for collaborating researchers or clinical ...
Reversible effects of the SARS-CoV-2 on semen parameters
Despite that the SARS-CoV-2 pandemic has been controlled, it has affected a large proportion of the population, raising some concerns about potential sequelae in men at reproductive age. To contribute to the clarification ...
Prognostic microRNAs in upper tract urothelial carcinoma: multicenter and international validation study
Objective: To validate previously discovered miRNAs (miR-31-5p and miR-149-5p) as prognostic factors for UTUC in an independent cohort of UTUC patients.Patients and Methods: Multicenter, international and retrospective ...
Reciprocal Negative Cross-Talk between Liver X Receptors (LXRs) and STAT1: Effects on IFN-gamma-Induced Inflammatory Responses and LXR-Dependent Gene Expression
Liver X receptors (LXRs) exert key functions in lipid homeostasis and in control of inflammation. In this study we have explored the impact of LXR activation on the macrophage response to the endogenous inflammatory cytokine ...
SARS-CoV-2 seroprevalence and preeclampsia markers in Mozambican pregnant women with perinatal loss.
Background SARS-CoV-2 infection during pregnancy is known to be associated with poor pregnancy outcomes, including pre-eclampsia (PE), prematurity, perinatal and maternal mortality. Data on the burden of SARS-CoV-2 infection ...
Liver X receptors and inflammatory-induced C/EBPβ selectively cooperate to control CD38 transcription
Introduction: Macrophages abundantly express liver X receptors (LXRs), which are ligand-dependent transcription factors and sensors of several cholesterol metabolites. In response to agonists, LXRs promote the expression ...
Differential impact of optogenetic stimulation of direct and indirect pathways from dorsolateral and dorsomedial striatum on motor symptoms in Huntington’s disease mice
The alterations in the basal ganglia circuitry are core pathological hallmark in Huntington's Disease (HD) and traditionally linked to its sever motor symptoms. Recently it was shown that optogenetic stimulation of cortical ...
Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction
PURPOSE: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. METHODS: Evaluation was performed using ...
Unconventional EGF-induced ERK1/2-mediated Kv1.3 endocytosis
The potassium channel Kv1.3 plays roles in immunity, neuronal development and sensory discrimination. Regulation of Kv1.3 by kinase signaling has been studied. In this context, EGF binds to specific receptors (EGFR) and ...
Increased translation in adult mouse striatum is sufficient to induce motor dysfunction
Protein synthesis is a process finely regulated in all cell types but specially in neurons as they need rapid changes in protein concentration for synaptic plasticity. Alterations in translation rates have been shown in ...
Don’t Take Away My P: Phosphatases as Therapeutic Targets in Huntington’s Disease
The molecular bases that account for the preferential neurodegeneration of striatal mediumsized spiny neurons (MSNs) in Huntington’s Disease (HD) are still unknown, and different mechanisms have been proposed to contribute ...
Andronet News. Summar 2024
With Summer drawing to an end, our Action had its main event of the year. At the beginning of September, we gathered in an unusually sunny and warm Stockholm to attend the European Congress of Andrology (ECA2024), ...
Andronet News. Summar 2023
Since most of us have just returned from the summer break, this edition will be shorter than usual. The main item is the brief report from our main event held in June in conjunction with the 22nd European Testis Workshop ...
