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PET Imaging of Self-Assembled 18F-Labelled Pd2L4 Metallacages for Anticancer Drug Delivery

To access the full text documents, please follow this link: http://hdl.handle.net/20.500.14342/4695

Author

Cosialls, Raúl

Simó, Cristina

Borrós, Salvador

Gómez Vallejo, Vanessa

Schmidt, Claudia

Llop, Jordi

Cuenca, Ana B.

Casini, Angela

Other authors

Universitat Ramon Llull. IQS

Publication date

2023-01-12



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Abstract

To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.

Document Type

Article

Document version

Published version

Language

English

CDU Subject

Subjects and keywords

Ammonium trifluoroborates; Cisplatin; Drug delivery; Metallacages; PET imaging; Self-assembly; Amoni; Cisplatí; Medicaments--Modes d'administració

Pages

p.7

Publisher

Wiley

Published in

Chemistry – A European Journal 2023, 29(3), e202202604

Grant Agreement Number

info:eu-repo/grantAgreement/MCI/PN I+D/PID2020-113661GB-I00

info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 01051

info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 00294

info:eu-repo/grantAgreement/MCI/PN I+D/PID2020-117656RB-I00

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Attribution 4.0 International

This item appears in the following Collection(s)

IQS [794]