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Imaging–guided optimization of biodistribution and antitumor efficacy of L19-based immunocytokines 

Virgilio, Tommaso; Chahine, Kamil; Guixeras-Carreras, Jordi; Pulfer, Alain; Pizzichetti, Chiara; Latino, Irene; Molina Romero, Daniel; Capucetti, Arianna; Luca Renner, Louis; Neri, Dario; Puca, Emanuele; De Luca, Roberto; F. Gonzalez, Santiago (Publication date: 2026-04)

Antibody-based targeted delivery of pharmaceuticals is an attractive approach to preferentially localize anti-cancer payloads to neoplastic lesions. The L19 antibody, specific for the extra domain B of fibronectin, is used ...

Direct UV photolysis of cloperastine in aqueous solution: Kinetic model and degradation pathway 

Marí­n-Garcí­a, Marc; González Olmos, Rafael; Gómez-Canela, Cristian (Publication date: 2026-01)

The increasing production and release of synthetic organic chemicals, including pharmaceuticals, into our environment has allowed these substances to accumulate in our surface water systems. Current purification technologies ...

Environmental risk assessment of pharmaceuticals in wastewaters and reclaimed water from catalan main river basins 

Domínguez García, Pol; Aljabasini, Ouwais; Barata, Carlos; Gómez-Canela, Cristian (Publication date: 2024-11-01)

Aquatic pollution from pharmaceuticals is a growing environmental concern globally, particularly in Catalonia's primary water bodies, the Llobregat and Besòs rivers. This study investigates pharmaceutical residues in ...

Predicted environmental concentrations to prioritize and determine geographical and temporal variation of 810 pharmaceuticals in wastewaters and rivers 

Domínguez García, Pol; Rodriguez Murillo, Natalia; Moreno, Anna; Lacorte, Silvia; Gomez, Cristian (Publication date: 2026-02-15)

Pharmaceuticals are considered emerging contaminants (ECs) due to their increasing presence in surface waters, largely caused by discharges from industries, domestic consumption and hospitals, and uncomplete elimination ...

Real-time prediction of influenza and respiratory syncytial virus epidemics in primary care using the Gompertz model 

Perramon Malavez, Aida; Ye, Qiaoling; López, Daniel; Montañola-Sales, Cristina; Alonso, Sergio; Álvarez, Enric; Soriano-Arandes, Antoni; Prats, Clara (Publication date: 2026-02-11)

Seasonal epidemics of influenza and respiratory syncytial virus (RSV)-bronchiolitis pose significant challenges for public health systems, requiring timely predictions for effective interventions. In this study, we applied ...

Sustainable encapsulation of lipophilic fragrances using biodegradable sodium alginate for cosmetic applications 

Tarrats i Duran, Anna; Borrós, Salvador; Rodrigo Magaña, José; Fornaguera, Cristina (Publication date: 2026-03)

The encapsulation of lipophilic compounds for use in the cosmetic, food, and detergency industries is an area of growing interest. However, most current strategies rely on non-biodegradable materials, often classified as ...

Tetra(4-carboxyphenyl)porphyrin-grafted chitosan fluorescent biopolymer: Synthesis, characterization, high DNA loading capacity and gene delivery 

Kumar, Santosh; Singh, Ira; Garg, Pankaj; Sobral, Abilio; KOH, JOONSEOK; Pandey, Shambhavi (Publication date: 2026-02)

Cationic polymer-based gene delivery vectors face several challenges, including low DNA loading capacity, rapid renal clearance, high toxicity due to non-degradability, and poor transfection efficiency. Chitosan offers a ...

Poset sensitivity analysis reveals post 2020 changes in human development index components 

Martori Adrian, Francesc; Hirai, Tadashi (Publication date: 2026-03-20)

This study assesses the sensitivity of the Human Development Index (HDI) using partially ordered set (poset) analysis. Unlike conventional methods, such as correlation, dominance, or simulation-based techniques, poset ...

Robust ECG signal classification using spiking neural networks with axonal delays 

Galvis Chacón, Javier; Ramos-Soto, Oscar; Oliva, Diego; Valdivia G., Arturo; Rostro Gonzalez, Horacio; Patino-Saucedo, Alberto (Publication date: 2026-02-26)

Cardiovascular diseases (CVD) continue to be the primary cause of mortality, with myocardial infarctions and strokes being the main contributors; according to the World Health Organization (WHO), timely diagnosis and ...

Acanthospermum hispidum and Its Metabolite Stigmasterol Modulates Anti-Inflammatory Antagonism of COX-1 and TGF-β 

Adeboye, Onome; Sowemimo, Abimbola; Fageyinbo, Muyiwa; Adedokun, Oluwasegun; Basit, Abdul; Olatunji, Opeyemi Joshua; Epole, Ntungwe (Publication date: 2026-01)

Acanthospermum hispidum (AH) leaves have been widely used in traditional medicine for inflammation. In this study, the anti-inflammatory effect of AH was evaluated, and a possible mechanism was predicted using an in silico ...

From Gut to Brain: Glyphosate and Triclosan Impair Microbiome Composition, Neuroactive Metabolites, and Cognitive and Ecological Fitness in Daphnia magna 

Romero Alfano, Irene; Julià-López, Alba; Piña, Benjamin; Gomez, Cristian; Barata, Carlos (Publication date: 2026-01-20)

Gut microbiome dysbiosis is a major off-target effect of many pharmaceuticals, personal care products (PPCP), and plant protection products (PPP). This study aims to characterize these effects for two compounds, glyphosate ...

Endovascular repair of aortic dissection with a bioresorbable patch: Computational and experimental study 

Bracco, Marta Irene; Canalejo-Codina, Francesc; Giuliodori, Agustina; Montanino, Andrea; Martorell, Jordi; Soudah, Eduardo (Publication date: 2026-03)

This study introduces an experimentally-calibrated finite-element framework to predict the endovascular sealing performance of a bioresorbable patch for aortic dissection repair. The patch–aortic wall interaction was modeled ...

Limblab: pipeline for 3D analysis and visualisation of limb bud gene expression 

Aviñó Esteban, Laura; Cardona, Heura; Musy, Marco; Matyjaszkiewicz, Antoni; Sharpe, James; Dalmasso, Giovanni (Publication date: 2026-01-12)

Background: Although some aspects of limb development can be treated as a 2D problem, a true understanding of the morphogenesis and patterning requires 3D analysis. Since the data on gene expression patterns are largely ...

Transient cognitive and affective impairments following short-term aluminum exposure in adult zebrafish 

Elizalde-Velazquez, Gustavo Axel; Selene Elizabeth, Herrera-Vázquez; Tagkalidou, Niki; Faria, Melissa; Romero Alfano, Irene; Prats, Eva; Verdaguer, Ariadna; Gómez-Canela, Cristian; Gómez-Oliván, Leobardo Manuel (Publication date: 2026-02)

Aluminum (Al) is a widespread aquatic neurotoxic pollutant, yet its brain accumulation is seldom quantified in fish neurotoxicity studies. Here, we investigated the neurobehavioral and molecular consequences of acute ...

Business model innovation from dynamic capabilities perspective: A systematic literature review 

Cruz-Sanchez, Oscar Mauricio; Cruz-Cázares, Claudio; Hernandez-Vivanco, Alfonso (Publication date: 2026-02)

Business model innovation (BMI) is increasingly recognized as a key source of competitive advantage and organizational performance. BMI is rooted in the dynamic capabilities (DC) perspective as an iterative process that ...

Unveiling the role of service quality in the quick service restaurant sector: An integrative review 

Mendocilla Meregildo, Mario Orlando; Miravitlles Matamoros, Paloma; Matute, Jorge (Publication date: 2026-01)

This study methodically examines the extant literature on service quality assessment in the Quick-Service Restaurant (QSR) sector to gain a deeper understanding of its role in this particular sector and to identify consistent ...

Copper Coils as Efficient and Inexpensive Reactors for the Synthesis of Tetrazoles in Flow Chemistry 

Molins Colomer, Maite; Roig, Natàlia; FERNANDEZ, JAVIER; Berzosa, Xavier (Publication date: 2025-09-29)

Sartans are an important family of drugs used to treat hypertension. A common characteristic of most of them is a biphenyl moiety with a tetrazole ring in the ortho position of the phenyl–phenyl bond. This tetrazole is ...

What makes hybrid companies attractive to potential employees? Insights from a cross-country analysis 

Riviere, Monica; Garcia Pereyra, Jose Facundo; MION, Giorgio (Publication date: 2025-09)

While hybrid companies (HCs)—businesses that pursue both economic and social goals—are gaining prominence, little is known about what makes them attractive to potential employees. This study addresses this gap by examining ...

Food waste in group dining: the interplay of shame and conflict aversion in the “last piece of food” dilemma 

Filimonau, Viachaslau; Matute, Jorge; Sezerel, Hakan; ÖZOĞUL BALYALI, TUĞÇE (Publication date: 2026-01)

Group dining at social or business occasions frequently encounters the “last piece of food” dilemma, where a single item remains uneaten when food is served to event guests on a shared plate. Despite its contribution to ...

Silver-coated silicone stents as an approach to prevent bacterial colonization of central airways after tracheobronchial stenting 

Lopez-Lisbona, Rosa; Calatayud, Laura; Gilabert Porres, Joan; Díez Ferrer, Marta; Borrós, Salvador; Ardanuy, Carmen; Santos, Salud; Rosell, Antoni; Martí, Sara (Publication date: 2025-12)

Rationale: Tracheobronchial stents are used to treat central airway obstruction but frequently develop bacterial colonization that can lead to infection. Objectives: To identify the microorganisms responsible for stent ...

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