Universitat Ramon Llull. IQS
2023-01-12
To advance the design of self-assembled metallosupramolecular architectures as new generation theranostic agents, the synthesis of 18F-labelled [Pd2L4]4+ metallacages is reported. Different spectroscopic and bio-analytical methods support the formation of the host-guest cage-cisplatin complex. The biodistribution profiles of one of the cages, alone or encapsulating cisplatin have been studied by PET/CT imaging in healthy mice in vivo, in combination to ICP-MS ex vivo.
Article
Versió publicada
Anglès
Ammonium trifluoroborates; Cisplatin; Drug delivery; Metallacages; PET imaging; Self-assembly; Amoni; Cisplatí; Medicaments--Modes d'administració
p.7
Wiley
Chemistry – A European Journal 2023, 29(3), e202202604
info:eu-repo/grantAgreement/MCI/PN I+D/PID2020-113661GB-I00
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 01051
info:eu-repo/grantAgreement/SUR del DEC/SGR/2017 SGR 00294
info:eu-repo/grantAgreement/MCI/PN I+D/PID2020-117656RB-I00
IQS [794]