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| dc.contributor.author | Cantero, Irene |
|---|---|
| dc.contributor.author | Abete, Itziar |
| dc.contributor.author | Babio, Nancy |
| dc.contributor.author | Arós, Fernando |
| dc.contributor.author | Corella Piquer, Dolores |
| dc.contributor.author | Estruch Riba, Ramon |
| dc.contributor.author | Fitó Colomer, Montserrat |
| dc.contributor.author | Hébert, James R. |
| dc.contributor.author | Martínez-González, Miguel Ángel, 1957- |
| dc.contributor.author | Pintó Sala, Xavier |
| dc.contributor.author | Portillo, María P. |
| dc.contributor.author | Ruiz-Canela, Miguel |
| dc.contributor.author | Shivappa, Nitin |
| dc.contributor.author | Wärnberg, Julia |
| dc.contributor.author | Gómez Gracia, Enrique |
| dc.contributor.author | Tur, Josep Antoni |
| dc.contributor.author | Salas Salvadó, Jordi |
| dc.contributor.author | Zulet, M. Angeles |
| dc.contributor.author | Martínez, J. Alfredo, 1957- |
| dc.date | 2019-12-04T09:29:20Z |
| dc.date | 2019-12-04T09:29:20Z |
| dc.date | 2018-10 |
| dc.date | 2019-12-04T09:29:20Z |
| dc.identifier | 0261-5614 |
| dc.identifier | 688106 |
| dc.identifier.uri | http://hdl.handle.net/2445/146044 |
| dc.description | BACKGROUND & AIMS: To assess the possible association between a validated Dietary Inflammatory Index (DII) and specific dietary components with suitable non-invasive markers of liver status in overweight and obese subjects within the PREDIMED study. METHODS: A cross-sectional study encompassing 794 randomized overweight and obese participants (mean ± SD age: 67.0 ± 5.0 y, 55% females) from the PREDIMED (PREvención con DIeta MEDiterránea) trial was conducted. DII is a validated tool evaluating the effect of diet on six inflammatory biomarkers (IL-1b, IL-4, IL-6, IL-10, TNF-α and C-reactive protein). Furthermore, a validated 137-item food-frequency-questionnaire was used to obtain the information about the food intake. In addition, anthropometric measurements and several non-invasive markers of liver status were assessed and the Fatty Liver Index (FLI) score was calculated. RESULTS: A higher DII and lower adherence to Mediterranean diet (MeDiet) were associated with a higher degree of liver damage (FLI > 60) in obese as compared to overweight participants. Furthermore, the DII score was positively associated with relevant non-invasive liver markers (ALT, AST, GGT and FLI) and directly affected FLI values. Interestingly, a positive correlation was observed between liver damage (>50th percentile FLI) and nutrients and foods linked to a pro-inflammatory dietary pattern. CONCLUSIONS: This study reinforced the concept that obesity is associated with liver damage and revealed that the consumption of a pro-inflammatory dietary pattern might contribute to obesity and fatty liver disease features. These data suggest that a well-designed precision diet including putative anti-inflammatory components could specifically prevent and ameliorate non-alcoholic fatty liver manifestations in addition to obesity. |
| dc.format | 8 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Elsevier |
| dc.relation | Versió postprint del document publicat a: https://doi.org/10.1016/j.clnu.2017.06.027 |
| dc.relation | Clinical Nutrition, 2018, vol. 37, num. 5, p. 1736-1743 |
| dc.relation | https://doi.org/10.1016/j.clnu.2017.06.027 |
| dc.rights | cc-by-nc-nd (c) Elsevier Ltd and European Society for Clinical Nutrition and Metabolism, 2018 |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Malalties del fetge |
| dc.subject | Teixit adipós |
| dc.subject | Liver diseases |
| dc.subject | Adipose tissues |
| dc.title | Dietary Inflammatory Index and liver status in subjects with different adiposity levels within the PREDIMED trial |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/acceptedVersion |
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