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| dc.contributor.author | Pereira, Licia P. |
|---|---|
| dc.contributor.author | Köhler, Cristiano A. |
| dc.contributor.author | Sousa, Rafael T. |
| dc.contributor.author | Solmi, Marco |
| dc.contributor.author | Freitas, Bárbara P. de |
| dc.contributor.author | Fornaro, Michele |
| dc.contributor.author | Machado-Vieira, Rodrigo |
| dc.contributor.author | Miskowiak, Kamilla W. |
| dc.contributor.author | Vieta i Pascual, Eduard, 1963- |
| dc.contributor.author | Veronese, Nicola |
| dc.contributor.author | Stubbs, Brendon |
| dc.contributor.author | Carvalho, André F. |
| dc.date | 2018-10-16T15:14:44Z |
| dc.date | 2019-07-01T05:10:14Z |
| dc.date | 2017-08-01 |
| dc.date | 2018-10-16T15:14:44Z |
| dc.identifier | 0149-7634 |
| dc.identifier | 671501 |
| dc.identifier | 28479278 |
| dc.identifier.uri | http://hdl.handle.net/2445/125372 |
| dc.description | Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach |
| dc.format | 61 p. |
| dc.format | application/pdf |
| dc.language | eng |
| dc.publisher | Elsevier |
| dc.relation | Versió postprint del document publicat a: https://doi.org/10.1016/j.neubiorev.2017.05.002 |
| dc.relation | Neuroscience and Biobehavioral Reviews, 2017, vol. 79, p. 87-109 |
| dc.relation | https://doi.org/10.1016/j.neubiorev.2017.05.002 |
| dc.rights | cc-by-nc-nd (c) Elsevier, 2017 |
| dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/es |
| dc.rights | info:eu-repo/semantics/openAccess |
| dc.subject | Trastorn bipolar |
| dc.subject | Imatges per ressonància magnètica |
| dc.subject | Cervell |
| dc.subject | Manic-depressive illness |
| dc.subject | Magnetic resonance imaging |
| dc.subject | Brain |
| dc.title | The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies |
| dc.type | info:eu-repo/semantics/article |
| dc.type | info:eu-repo/semantics/acceptedVersion |
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Pereira, Licia P.; Köhler, Cristiano A.; Sousa, Rafael T.; Solmi, Marco; Freitas, Bárbara P. de; Fornaro, Michele; Machado-Vieira, Rodrigo; Miskowiak, Kamilla W.; Vieta i Pascual, Eduard, 1963-; Veronese, Nicola; Stubbs, Brendon; Carvalho, André F.
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