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Title:	The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies
Author:	Pereira, Licia P.; Köhler, Cristiano A.; Sousa, Rafael T.; Solmi, Marco; Freitas, Bárbara P. de; Fornaro, Michele; Machado-Vieira, Rodrigo; Miskowiak, Kamilla W.; Vieta i Pascual, Eduard, 1963-; Veronese, Nicola; Stubbs, Brendon; Carvalho, André F.
Notes:	Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach. Replicated evidence (i.e. in >2 studies) suggests that individuals with BD carrying the BDNF Val66Met risk allele could have reduced hippocampal volumes compared to non-carriers. This review underscores the potential of gene-neuroimaging paradigms to provide mechanistic insights for BD. However, this systematic review found a single replicated finding. Suggestions to improve the reproducibility of this emerging field are provided, including the adoption of a trans-diagnostic approach
Subject(s):	-Trastorn bipolar -Imatges per ressonància magnètica -Cervell -Manic-depressive illness -Magnetic resonance imaging -Brain
Rights:	cc-by-nc-nd (c) Elsevier, 2017 http://creativecommons.org/licenses/by-nc-nd/3.0/es
Document type:	Article Article - Accepted version
Published by:	Elsevier
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