To access the full text documents, please follow this link: http://hdl.handle.net/2445/113202
dc.contributor.author | Bautista Rodríguez, Carles |
---|---|
dc.contributor.author | Launes Montaña, Cristian |
dc.contributor.author | Jordán García, Iolanda |
dc.contributor.author | Andrés, Maria |
dc.contributor.author | Arias, Maria Teresa |
dc.contributor.author | Lozano Soto, Francisco |
dc.contributor.author | García García, Juan José |
dc.contributor.author | Muñoz-Almagro, Carmen |
dc.date | 2017-07-03T06:34:16Z |
dc.date | 2017-07-03T06:34:16Z |
dc.date | 2017-05-31 |
dc.date | 2017-07-03T06:34:17Z |
dc.identifier | 1932-6203 |
dc.identifier | 672568 |
dc.identifier | 28562692 |
dc.identifier.uri | http://hdl.handle.net/2445/113202 |
dc.description | OBJECTIVES: The objective of this study was to evaluate to evaluate the role of mannose-binding-lectin deficient genotypes in pneumococcal meningitis (PM) in children. METHODS: We performed a 16-year retrospective study (January 2001 to March 2016) including patients ≤ 18 years with PM. Variables including attack rate of pneumococcal serotype (high or low invasive capacity) and MBL2 genotypes associated with low serum MBL levels were recorded. RESULTS: Forty-eight patients were included in the study. Median age was 18.5 months and 17/48 episodes (35.4%) occurred in children ≤ 12 months old. Serotypes with high-invasive disease potential were identified in 15/48 episodes (31.2%). MBL2 deficient genotypes accounted for 18.8% (9/48). Children ≤ 12 months old had a 7-fold risk (95% CI: 1.6-29.9; p < 0.01) of having a MBL2 deficient genotype in comparison to those > 12 months old. A sub-analysis of patients by age group revealed significant proportions of carriers of MBL2 deficient genotypes among those ≤ 12 months old with PM caused by opportunistic serotypes (54.5%), admitted to the PICU (Pediatric Intensive Care Unit) (46.7%) and of White ethnicity (35.7%). These proportions were significantly higher than in older children (all p<0.05). CONCLUSIONS: Our results suggest that differences in MBL2 genotype in children ≤12 months old affects susceptibility to PM, and it may have an important role in the episodes caused by non-high invasive disease potential serotypes. |
dc.format | 9 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | Public Library of Science (PLoS) |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0178377 |
dc.relation | PLoS One, 2017, vol. 12, num. 5, p. e0178377 |
dc.relation | https://doi.org/10.1371/journal.pone.0178377 |
dc.rights | cc-by (c) Bautista-Rodríguez, Carles et al., 2017 |
dc.rights | http://creativecommons.org/licenses/by/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Meningitis |
dc.subject | Infeccions per pneumococs |
dc.subject | Infants |
dc.subject | Epidemiologia |
dc.subject | Salut pública |
dc.subject | Unitats de cures intensives |
dc.subject | Meningitis |
dc.subject | Pneumococcal Infections |
dc.subject | Children |
dc.subject | Epidemiology |
dc.subject | Public health |
dc.subject | Intensive care units |
dc.title | Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |