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Título:	Mannose-binding lectin-deficient genotypes as a risk factor of pneumococcal meningitis in infants
Autor/a:	Bautista Rodríguez, Carles; Launes Montaña, Cristian; Jordán García, Iolanda; Andrés, Maria; Arias, Maria Teresa; Lozano Soto, Francisco; García García, Juan José; Muñoz-Almagro, Carmen
Notas:	OBJECTIVES: The objective of this study was to evaluate to evaluate the role of mannose-binding-lectin deficient genotypes in pneumococcal meningitis (PM) in children. METHODS: We performed a 16-year retrospective study (January 2001 to March 2016) including patients ≤ 18 years with PM. Variables including attack rate of pneumococcal serotype (high or low invasive capacity) and MBL2 genotypes associated with low serum MBL levels were recorded. RESULTS: Forty-eight patients were included in the study. Median age was 18.5 months and 17/48 episodes (35.4%) occurred in children ≤ 12 months old. Serotypes with high-invasive disease potential were identified in 15/48 episodes (31.2%). MBL2 deficient genotypes accounted for 18.8% (9/48). Children ≤ 12 months old had a 7-fold risk (95% CI: 1.6-29.9; p < 0.01) of having a MBL2 deficient genotype in comparison to those > 12 months old. A sub-analysis of patients by age group revealed significant proportions of carriers of MBL2 deficient genotypes among those ≤ 12 months old with PM caused by opportunistic serotypes (54.5%), admitted to the PICU (Pediatric Intensive Care Unit) (46.7%) and of White ethnicity (35.7%). These proportions were significantly higher than in older children (all p<0.05). CONCLUSIONS: Our results suggest that differences in MBL2 genotype in children ≤12 months old affects susceptibility to PM, and it may have an important role in the episodes caused by non-high invasive disease potential serotypes.
Materia(s):	-Meningitis -Infeccions per pneumococs -Infants -Epidemiologia -Salut pública -Unitats de cures intensives -Meningitis -Pneumococcal Infections -Children -Epidemiology -Public health -Intensive care units
Derechos:	cc-by (c) Bautista-Rodríguez, Carles et al., 2017 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Public Library of Science (PLoS)
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