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dc.contributor.author | Jiménez, Amanda |
---|---|
dc.contributor.author | Mari, Andrea |
dc.contributor.author | Casamitjana i Abellà, Roser |
dc.contributor.author | Lacy Fortuny, Antonio Ma. de |
dc.contributor.author | Ferrannini, Ele |
dc.contributor.author | Vidal i Cortada, Josep |
dc.date | 2017-06-16T07:45:04Z |
dc.date | 2017-06-16T07:45:04Z |
dc.date | 2014-05-21 |
dc.date | 2017-06-16T07:45:04Z |
dc.identifier | 0012-1797 |
dc.identifier | 646688 |
dc.identifier | 24848069 |
dc.identifier.uri | http://hdl.handle.net/2445/112443 |
dc.description | Although GLP-1 has been suggested as a major factor for the marked improvement of glucose tolerance commonly seen after sleeve gastrectomy (SG), several observations challenge this hypothesis. To better understand the role of GLP-1 in the remission of type 2 diabetes mellitus (T2DM) long term after SG in humans, we conducted two separate cross-sectional studies: 1) the GLP-1 response to a standardized mixed liquid meal (SMLM) was compared in subjects with T2DM antedating SG but with different long-term (>2 years) T2DM outcomes (remission, relapse, or lack of remission) (study 1) and 2) the effect of GLP-1 receptor blockade with exendin (9-39) on glucose tolerance was examined in subjects with T2DM antedating surgery, who had undergone SG and presented with long-term T2DM remission (study 2). In study 1, we observed a comparable GLP-1 response to the SMLM regardless of the post-SG outcome of T2DM. In study 2, the blockade of GLP-1 action resulted in impaired insulin secretion but limited deterioration of glucose tolerance. Thus, our data suggest the enhanced GLP-1 secretion observed long term after SG is neither sufficient nor critical to maintain normal glucose tolerance in subjects with T2DM antedating the surgery. |
dc.format | 6 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | American Diabetes Association |
dc.relation | Reproducció del document publicat a: https://doi.org/10.2337/db14-0357 |
dc.relation | Diabetes, 2014, vol. 63, num. 10, p. 3372-3377 |
dc.relation | https://doi.org/10.2337/db14-0357 |
dc.rights | cc-by-nc-nd (c) American Diabetes Association, 2014 |
dc.rights | http://creativecommons.org/licenses/by-nc-nd/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Obesitat mòrbida |
dc.subject | Diabetis no-insulinodependent |
dc.subject | Cirurgia digestiva |
dc.subject | Estudi de casos |
dc.subject | Morbid obesity |
dc.subject | Non-insulin-dependent diabetes |
dc.subject | Gastrointestinal surgery |
dc.subject | Case studies |
dc.title | GLP-1 and glucose tolerance after sleeve gastrectomy in morbidly obese subjects with type 2 diabetes. |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |