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Título:	GLP-1 and glucose tolerance after sleeve gastrectomy in morbidly obese subjects with type 2 diabetes.
Autor/a:	Jiménez, Amanda; Mari, Andrea; Casamitjana i Abellà, Roser; Lacy Fortuny, Antonio Ma. de; Ferrannini, Ele; Vidal i Cortada, Josep
Notas:	Although GLP-1 has been suggested as a major factor for the marked improvement of glucose tolerance commonly seen after sleeve gastrectomy (SG), several observations challenge this hypothesis. To better understand the role of GLP-1 in the remission of type 2 diabetes mellitus (T2DM) long term after SG in humans, we conducted two separate cross-sectional studies: 1) the GLP-1 response to a standardized mixed liquid meal (SMLM) was compared in subjects with T2DM antedating SG but with different long-term (>2 years) T2DM outcomes (remission, relapse, or lack of remission) (study 1) and 2) the effect of GLP-1 receptor blockade with exendin (9-39) on glucose tolerance was examined in subjects with T2DM antedating surgery, who had undergone SG and presented with long-term T2DM remission (study 2). In study 1, we observed a comparable GLP-1 response to the SMLM regardless of the post-SG outcome of T2DM. In study 2, the blockade of GLP-1 action resulted in impaired insulin secretion but limited deterioration of glucose tolerance. Thus, our data suggest the enhanced GLP-1 secretion observed long term after SG is neither sufficient nor critical to maintain normal glucose tolerance in subjects with T2DM antedating the surgery.
Materia(s):	-Obesitat mòrbida -Diabetis no-insulinodependent -Cirurgia digestiva -Estudi de casos -Morbid obesity -Non-insulin-dependent diabetes -Gastrointestinal surgery -Case studies
Derechos:	cc-by-nc-nd (c) American Diabetes Association, 2014 http://creativecommons.org/licenses/by-nc-nd/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	American Diabetes Association
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