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dc.contributor.author | García-Negredo, Gloria |
---|---|
dc.contributor.author | Soto del Cerro, David |
dc.contributor.author | Llorente, Javier |
dc.contributor.author | Morató Arús, Xavier |
dc.contributor.author | Galenkamp, Koen M.O. |
dc.contributor.author | Gómez Soler, Maricel |
dc.contributor.author | Fernández Dueñas, Víctor |
dc.contributor.author | Watanabe, Masahiko |
dc.contributor.author | Adelman, John P. |
dc.contributor.author | Shigemoto, Ryuichi |
dc.contributor.author | Fukazawa, Yugo |
dc.contributor.author | Luján, Rafael |
dc.contributor.author | Ciruela Alférez, Francisco |
dc.date | 2017-05-04T12:23:34Z |
dc.date | 2017-05-04T12:23:34Z |
dc.date | 2014-10-29 |
dc.date | 2017-05-04T12:23:34Z |
dc.identifier | 0270-6474 |
dc.identifier | 643622 |
dc.identifier | 25355231 |
dc.identifier.uri | http://hdl.handle.net/2445/110442 |
dc.description | Group I metabotropic glutamate (mGlu) receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca(2+) wave-dependent activation of small-conductance Ca(2+)-activated K(+) (SK) channels. Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain. Further, in cotransfected cells or rat primary hippocampal neurons, mGlu5 receptor stimulation activated apamin-sensitive SK2-mediated K(+) currents. In addition, coexpression of mGlu5 receptors and SK2 channels promoted plasma membrane targeting of both proteins and correlated with increased mGlu5 receptor function that was unexpectedly blocked by apamin. These results demonstrate a reciprocal functional interaction between mGlu5 receptors and SK2 channels that reflects their molecular coassembly. |
dc.format | 10 p. |
dc.format | application/pdf |
dc.language | eng |
dc.publisher | The Society for Neuroscience |
dc.relation | Reproducció del document publicat a: https://doi.org/10.1523/JNEUROSCI.2038-14.2014 |
dc.relation | Journal of Neuroscience, 2014, vol. 34, num. 44, p. 14793-14802 |
dc.relation | https://doi.org/10.1523/JNEUROSCI.2038-14.2014 |
dc.rights | cc-by-nc-sa (c) García-Negredo, Gloria et al., 2014 |
dc.rights | http://creativecommons.org/licenses/by-nc-sa/3.0/es |
dc.rights | info:eu-repo/semantics/openAccess |
dc.subject | Canals de potassi |
dc.subject | Neurologia |
dc.subject | Hipocamp (Cervell) |
dc.subject | Farmacologia |
dc.subject | Rates (Animals de laboratori) |
dc.subject | Potassium channels |
dc.subject | Neurology |
dc.subject | Hippocampus (Brain) |
dc.subject | Pharmacology |
dc.subject | Rats as laboratory animals |
dc.title | Coassembly and coupling of SK2 channels and mGlu5 receptors |
dc.type | info:eu-repo/semantics/article |
dc.type | info:eu-repo/semantics/publishedVersion |