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Título:	Coassembly and coupling of SK2 channels and mGlu5 receptors
Autor/a:	García-Negredo, Gloria; Soto del Cerro, David; Llorente, Javier; Morató Arús, Xavier; Galenkamp, Koen M.O.; Gómez Soler, Maricel; Fernández Dueñas, Víctor; Watanabe, Masahiko; Adelman, John P.; Shigemoto, Ryuichi; Fukazawa, Yugo; Luján, Rafael; Ciruela Alférez, Francisco
Notas:	Group I metabotropic glutamate (mGlu) receptors regulate hippocampal CA1 pyramidal neuron excitability via Ca(2+) wave-dependent activation of small-conductance Ca(2+)-activated K(+) (SK) channels. Here, we show that mGlu5 receptors and SK2 channels coassemble in heterologous coexpression systems and in rat brain. Further, in cotransfected cells or rat primary hippocampal neurons, mGlu5 receptor stimulation activated apamin-sensitive SK2-mediated K(+) currents. In addition, coexpression of mGlu5 receptors and SK2 channels promoted plasma membrane targeting of both proteins and correlated with increased mGlu5 receptor function that was unexpectedly blocked by apamin. These results demonstrate a reciprocal functional interaction between mGlu5 receptors and SK2 channels that reflects their molecular coassembly.
Materia(s):	-Canals de potassi -Neurologia -Hipocamp (Cervell) -Farmacologia -Rates (Animals de laboratori) -Potassium channels -Neurology -Hippocampus (Brain) -Pharmacology -Rats as laboratory animals
Derechos:	cc-by-nc-sa (c) García-Negredo, Gloria et al., 2014 http://creativecommons.org/licenses/by-nc-sa/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	The Society for Neuroscience
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