Título:
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New amino acid based biodegradable poly(ester amide)s via bis-azlactone chemistry
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Autor/a:
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Kobauri, Sophio; Otinashvili, Giuli; Kantaria, Tengiz; Tugushi, David; Kharadze, Darejan; Kutsiava, Nazi; Puiggalí Bellalta, Jordi; Katsarava, Ramaz
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Otros autores:
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Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. PSEP - Polimers Sintètics: Estructura i Propietats. Polimers Biodegradables. |
Abstract:
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Three new classes of the amino acid based biodegradable (AABB) polymers were synthesized via step growth polymerization of bis-azlactones and amino acid based diamine-diesters with activated fatty diester and alkylenediamine: a) poly(ester amide)s (PEAs) were obtained by polymerization of bis-azlactones with diamine-diesters, b) hydrophobically modified co-poly(ester amide)s (co-PEAs) were synthesized by copolymerization of activated fatty diacid diester and bis-azlactones with diamine-diesters, and c) poly(ester amide-co-amide)s (PEA-co-PAs) were obtained by copolymerization of alkylene diamine and diamine-diesters with bis-azlactones. The new poly(ester amide)s showed relatively low-molecular-weights (Mw within 2,800–19,600¿Da, GPC in DMF), whereas the new co-poly(ester amide)s and poly(ester amide-co-amide)s exhibited high-molecular-weights (Mw within 40–100¿kDa) leading to good mechanical properties. Incorporation of the bis-azlactone fragments into the poly(ester amide)s backbone increased hydrophobicity and thermal stability, whereas incorporation of diamine-diester units into the backbone of the bis-azlactone based polyamides rendered them biodegradable. Synthesized AABB polymers are potential candidates for constructing resorbable surgical and pharmaceutical devices. |
Abstract:
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Peer Reviewed |
Materia(s):
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-Àrees temàtiques de la UPC::Enginyeria química -Polymers -Amino acids -bis-azlactones -a-amino acids -diamine-diesters -biodegradable polymers -poly(ester amide)s -co-poly(ester amide)s -poly(ester amides-co-amide) -synthesis -hydrophobicity -thermal properties -in vitro biodegradation -Aminoàcids -Polímers |
Derechos:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento:
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Artículo - Versión publicada Artículo |
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