Title:
|
Extending the substrate scope in the hydrogenation of unfunctionalized tetrasubstituted olefins with Ir-P stereogenic aminophosphine-oxazoline catalysts
|
Author:
|
Biosca, Maria; Salomó, Ernest; Cruz Sánchez, Pol de la; Riera i Escalé, Antoni; Verdaguer i Espaulella, Xavier; Pàmies, Oscar; Diéguez, Montserrat
|
Other authors:
|
Universitat de Barcelona |
Abstract:
|
Air stable and readily available Ir-catalyst precursors modified with MaxPHOX-type ligands have been successfully applied in the challenging asymmetric hydrogenation of tetrasubstituted olefins under mild reaction conditions. Gratifyingly, these catalyst precursors are not only able to efficiently hydrogenate a range of indene derivatives (ee's up to 96%) but also 1,2-dihydro-napthalene derivatives and acyclic olefins (ee's up to 99%), which both constitute the most challenging substrates for this transformation. |
Subject(s):
|
-Hidrogenació -Catàlisi -Lligands (Bioquímica) -Hydrogenation -Catalysis -Ligands (Biochemistry) |
Rights:
|
(c) American Chemical Society , 2019
|
Document type:
|
Article Article - Accepted version |
Published by:
|
American Chemical Society
|
Share:
|
|