Título:
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Enantioselective Total Synthesis of (+)-Gephyrotoxin 287C
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Autor/a:
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Piccichè, Miriam; Pinto, Alexandre; Griera Farres, Rosa; Bosch Cartes, Joan; Amat Tusón, Mercedes
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Otros autores:
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Universitat de Barcelona |
Abstract:
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A synthesis of (+)-gephyrotoxin 287C using, (S)-phenylglycinol-derived tricyclic lactam 7 as the starting enantiomeric scaffold is reported. From the stereochemical standpoint, the key steps are the generation of the DHQ C-5 stereocenter by hydrogenation of the C-C double bond, removal of the chiral inductor to give a cis-DHQ introduction of the DHQ C-2 substituent, completion of the (Z)-enyne moiety, and generation of the C-1 stereocenter during closure of the pyrrolidine ring. |
Materia(s):
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-Síntesi asimètrica -Lactames -Catàlisi asimètrica -Asymmetric synthesis -Lactams -Enantioselective catalysis |
Derechos:
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(c) American Chemical Society , 2017
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Tipo de documento:
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Artículo Artículo - Versión aceptada |
Editor:
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American Chemical Society
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