Title:
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Stereocontrolled access to enantiopure to enantiopure 7-substituted cis- and trans-octahydroindoles
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Author:
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Ghirardi, Elena; Griera Farres, Rosa; Piccichè, Miriam; Molins i Grau, Elies; Fernández Cadenas, Israel; Bosch Cartes, Joan; Amat Tusón, Mercedes
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Other authors:
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Universitat de Barcelona |
Abstract:
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Cyclocondensation of (R)-phenylglycinol with stereoisomeric mixtures (racemates, cis/trans) of 3-substituted 2- oxocyclohexaneacetates stereoselectively afforded tricyclic oxazoloindolone lactams, from which straightforward procedures for the stereocontrolled formation of enantiopure 7-substituted octahydroindoles with a variety of stereochemical patterns have been developed. The methodology has been successfully applied to the synthesis of (+)-α-lycorane. |
Subject(s):
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-Lactames -Síntesi asimètrica -Lactams -Asymmetric synthesis |
Rights:
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(c) American Chemical Society , 2016
info:eu-repo/semantics/embargoedAccess |
Document type:
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Article Article - Accepted version |
Published by:
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American Chemical Society
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