Title:
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CTDquerier: A Bioconductor R package for Comparative
Toxicogenomics DatabaseTM data extraction, visualization and
enrichment of environmental and toxicological studies
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Author:
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Hernández Ferrer, Carles; González, Juan R.
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Abstract:
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Biomedical studies currently include a large volume of
genomic and environmental factors for studying the etiology of
human diseases. R/Bioconductor projects provide several tools
for performing enrichment analysis at gene-pathway level,
allowing researchers to develop novel hypotheses. However, there
is a need to perform similar analyses at the chemicals-genes or
chemicals-diseases levels, to provide complementary knowledge of
the causal path between chemicals and diseases. While the
Comparative Toxicogenomics DatabaseTM (CTD) provides information
about these relationships, there is no software for integrating
it into R/Bioconductor analysis pipelines. CTDquerier helps
users to easily download CTD data and integrate it in the
R/Bioconductor framework. The package also contains functions
for visualizing CTD data and performing enrichment analyses. We
illustrate how to use the package with a real data analysis of
asthma-related genes. CTDquerier is a flexible and easy-to-use
Bioconductor package that provides novel hypothesis about the
relationships between chemicals and diseases. Availability and
implementation: CTDquerier R package is available through
Bioconductor and its development version at
https://github.com/isglobal-brge/CTDquerier. Contact:
juanr.gonzalez@isglobal.org. Supplementary information:
Supplementary data are available at Bioinformatics online. |
Subject(s):
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-Ciències de la salut -Etiologia -Medical sciences -Etiology |
Rights:
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cc by-nc (c) Hernández Ferrer, Carles; González, Juan R., 2018
http://creativecommons.org/licenses/by-nc/3.0/es/ |
Document type:
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Article Article - Published version |
Published by:
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Oxford University Press
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