Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films

Home | About RECERCAT | Contact

Català | Castellano

All of RECERCAT

By Communities &
Collections By Defense Date By Authors By Titles By Subject

This Collection

By Defense Date By Authors By Titles By Subject

Statistics

View Statistics All RECERCAT

My RECERCAT

Other repositories directory

RECERCAT Home > Universitat Politècnica de Catalunya > Documents de recerca > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2117/121514

dc.contributor	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química
dc.contributor	Universitat Politècnica de Catalunya. Departament de Física
dc.contributor	Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial
dc.contributor	Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
dc.contributor.author	Francesko, Antonio
dc.contributor.author	Ivanova, Kristina Dimitrova
dc.contributor.author	Hoyo Pérez, Javier
dc.contributor.author	Pérez-Rafael, Silvia
dc.contributor.author	Petkova, Petya
dc.contributor.author	Fernandes Macedo, Margarida Maria
dc.contributor.author	Heinze, Thomas
dc.contributor.author	Mendoza Gómez, Ernesto
dc.contributor.author	Tzanov, Tzanko
dc.date	2018-07-27
dc.identifier.citation	Francesko, A., Ivanova, K., Hoyo, J., Pérez-Rafael, S., Petkova, P., Fernandes, M., Heinze, T., Mendoza, E., Tzanov, T. Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films. "Biomacromolecules", 27 Juliol 2018, vol. 19, núm. 9, p. 3628-3636.
dc.identifier.citation	1525-7797
dc.identifier.citation	10.1021/acs.biomac.8b00626
dc.identifier.uri	http://hdl.handle.net/2117/121514
dc.description.abstract	In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions ofAgNPs decorated with chitosan (CS) or aminocellulose (AC) were synthesized by applying high intensity ultrasound. These polycationic nanoentities were layer-by-layer assembled with the HA polyanion to generate stable 3D supramolecular constructs, where the biopolymer-capped AgNPs play the dual role of active agent and structural element. SEM images of the assemblies revealed gradual increase of thickness with the number of deposited bilayers. The composites of =50 bilayers were safe to human cells and demonstrated 100% antibacterial activity against Staphylococcus aureus and Escherichia coli. Moreover, the films containing CSAgNPs brought about the total prevention of biofilm formation reducing the cells surface adherence by up to 6 logs. Such nanobiocomposites could serve as an effective barrier to control bacterial growth on injured skin, burns, and chronic wounds.
dc.description.abstract	Peer Reviewed
dc.language.iso	eng
dc.relation	https://pubs.acs.org/doi/10.1021/acs.biomac.8b00626
dc.rights	Attribution-NonCommercial-NoDerivs 3.0 Spain
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	http://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.subject	Àrees temàtiques de la UPC::Enginyeria química
dc.subject	Chitosan
dc.subject	Biopolymers
dc.subject	Nanoparticles--therapeutic use
dc.subject	chitosan
dc.subject	aminocellulose
dc.subject	hyaluronic acid
dc.subject	biopolyme r-capped silver 1 nanoparticles
dc.subject	layer-by-layer
dc.subject	freestanding antimicrobial films
dc.subject	Quitosan
dc.subject	Biopolímers
dc.subject	Nanopartícules -- Ús terapèutic
dc.title	Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films
dc.type	info:eu-repo/semantics/submittedVersion
dc.type	info:eu-repo/semantics/article

Show simple item record

All of RECERCAT

This Collection

Statistics

My RECERCAT

Related documents

Other documents of the same author