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Title:	Bottom-up layer-by-layer assembling of antibacterial freestanding nanobiocomposite films
Author:	Francesko, Antonio; Ivanova, Kristina Dimitrova; Hoyo Pérez, Javier; Pérez-Rafael, Silvia; Petkova, Petya; Fernandes Macedo, Margarida Maria; Heinze, Thomas; Mendoza Gómez, Ernesto; Tzanov, Tzanko
Other authors:	Universitat Politècnica de Catalunya. Departament d'Enginyeria Química; Universitat Politècnica de Catalunya. Departament de Física; Universitat Politècnica de Catalunya. GBMI - Grup de Biotecnologia Molecular i Industrial; Universitat Politècnica de Catalunya. GCM - Grup de Caracterització de Materials
Abstract:	In this study, freestanding nanobiocomposite films were obtained by the sequential deposition of biopolymer-capped silver nanoparticles (AgNPs) and hyaluronic acid (HA). At first, dispersions ofAgNPs decorated with chitosan (CS) or aminocellulose (AC) were synthesized by applying high intensity ultrasound. These polycationic nanoentities were layer-by-layer assembled with the HA polyanion to generate stable 3D supramolecular constructs, where the biopolymer-capped AgNPs play the dual role of active agent and structural element. SEM images of the assemblies revealed gradual increase of thickness with the number of deposited bilayers. The composites of =50 bilayers were safe to human cells and demonstrated 100% antibacterial activity against Staphylococcus aureus and Escherichia coli. Moreover, the films containing CSAgNPs brought about the total prevention of biofilm formation reducing the cells surface adherence by up to 6 logs. Such nanobiocomposites could serve as an effective barrier to control bacterial growth on injured skin, burns, and chronic wounds.
Abstract:	Peer Reviewed
Subject(s):	-Àrees temàtiques de la UPC::Enginyeria química -Chitosan -Biopolymers -Nanoparticles--therapeutic use -chitosan -aminocellulose -hyaluronic acid -biopolyme r-capped silver 1 nanoparticles -layer-by-layer -freestanding antimicrobial films -Quitosan -Biopolímers -Nanopartícules -- Ús terapèutic
Rights:	Attribution-NonCommercial-NoDerivs 3.0 Spain http://creativecommons.org/licenses/by-nc-nd/3.0/es/
Document type:	Article - Submitted version Article
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