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Title:
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Effect of RyR2 refractoriness and hypercalcemia on calcium overload, spontaneous release, and calcium alternans
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Author:
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Álvarez Lacalle, Enrique; Peñaranda Ayllón, Angelina; Rodríguez Cantalapiedra, Inma; Hove-Madsen, Leif; Echebarría Domínguez, Blas
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Other authors:
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Universitat Politècnica de Catalunya. Departament de Física; Universitat Politècnica de Catalunya. BIOCOM-SC - Grup de Biologia Computacional i Sistemes Complexos; Universitat Politècnica de Catalunya. ANCORA - Anàlisi i control del ritme cardíac; Universitat Politècnica de Catalunya. GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació |
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Abstract:
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In this work we use a computer model of a ventricular
rabbit myocyte to study several factors that affect sarcoplasmic
reticulum (SR) calcium load, such as hypercalcemia,
SR calcium buffering, or ryanodine receptor (RyR2)
dynamics. General conditions for the appearance of calcium
spontaneous release in situations with calcium overload
are obtained. Furthermore, we study the appearance
of alternans under these conditions. The presence of calcium
alternans may be due to either a steep calcium load
release relation, resulting in oscillations in SR Ca content,
or to a slow recovery from refractoriness of the RyR2. We
find that a change in calsequestrin buffering dynamics or
extracellular calcium concentration greatly affects the appearance
of the former type of alternans, but not of the
latter. |
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Abstract:
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Peer Reviewed |
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Subject(s):
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-Àrees temàtiques de la UPC::Enginyeria biomèdica::Electrònica biomèdica::Electrònica en cardiologia
-Cardiology
-Electronics in cardiology
-Calcium
-Load modeling
-Rabbits
-Oscillators
-Loading
-Extracellular
-Transient analysis
-physiological models
-biochemistry
-calcium
-cellular transport
-medical computing
-medical disorders
-molecular biophysics
-muscle
-Cardiologia
-Cardiologia -- Aparells i intruments |
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Rights:
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Document type:
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Article - Published version
Article |
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