Título:
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Dependency of calcium alternans on Ryanodine Receptor Refractoriness
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Autor/a:
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Álvarez Lacalle, Enrique; Rodríguez Cantalapiedra, Inma; Peñaranda Ayllón, Angelina; Cinca, J.; Hove-Madsen, Leif; Echebarría Domínguez, Blas
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Otros autores:
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Universitat Politècnica de Catalunya. Departament de Física Aplicada; Universitat Politècnica de Catalunya. NOLIN - Física No-Lineal i Sistemes Fora de l'Equilibri; Universitat Politècnica de Catalunya. GICITED - Grup Interdiciplinari de Ciència i Tecnologia en l'Edificació |
Abstract:
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Background
Rapid pacing rates induce alternations in the cytosolic calcium concentration caused by fluctuations in calcium rele
However, the relationship between calcium alternans and refractoriness of the SR calcium release channel (RyR2)
Methodology/Principal Findings
To investigate how ryanodine receptor (RyR2) refractoriness modulates calcium handling on a beat-to-beat basis u
used a mathematical rabbit cardiomyocyte model to study the beat-to-beat calcium response as a function of RyR
were constructed depicting the beat-to-beat response. When alternans was observed, a novel numerical clamping
was caused by oscillations in SR calcium loading or by RyR2 refractoriness. Using this protocol, we identified regio
loading or RyR2 refractoriness underlie the induction of calcium alternans, and we found that at the onset of altern
inactivation rates of the RyR2, calcium alternans was caused by alternation in SR calcium loading, while at low act
level of available RyR2s.
Conclusions/Significance
We have mapped cardiomyocyte beat-to-beat responses as a function of RyR2 activation and inactivation, identify
refractoriness underlie the induction of calcium alternans. A corollary of this work is that RyR2 refractoriness due t
of calcium alternans even when alternation in SR calcium load is present. |
Abstract:
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Peer Reviewed |
Materia(s):
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-Àrees temàtiques de la UPC::Ciències de la salut -Ryanodine--Receptors -Receptors (Biologia) |
Derechos:
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Attribution-NonCommercial-NoDerivs 3.0 Spain
http://creativecommons.org/licenses/by-nc-nd/3.0/es/ |
Tipo de documento:
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Artículo - Versión publicada Artículo |
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