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Oxygen pathway modeling estimates high Reactive oxygen species production above the highest permanent human habitation.
Cano Franco, Isaac; Selivanov, Vitaly A.; Gomez Cabrero, David; Tegnér, Jesper; Roca Torrent, Josep; Wagner, P. D. (Peter D.); Cascante i Serratosa, Marta
Universitat de Barcelona
The production of reactive oxygen species (ROS) from the inner mitochondrial membrane is one of many fundamental processes governing the balance between health and disease. It is well known that ROS are necessary signaling molecules in gene expression, yet when expressed at high levels, ROS may cause oxidative stress and cell damage. Both hypoxia and hyperoxia may alter ROS production by changing mitochondrial Po2 (). Because depends on the balance between O2 transport and utilization, we formulated an integrative mathematical model of O2 transport and utilization in skeletal muscle to predict conditions to cause abnormally high ROS generation. Simulations using data from healthy subjects during maximal exercise at sea level reveal little mitochondrial ROS production. However, altitude triggers high mitochondrial ROS production in muscle regions with high metabolic capacity but limited O2 delivery. This altitude roughly coincides with the highest location of permanent human habitation. Above 25,000 ft., more than 90% of exercising muscle is predicted to produce abnormally high levels of ROS, corresponding to the "death zone" in mountaineering.
Oxigen en l'organisme
Oxigen
Mitocondris
Respiració
Oxygen in the body
Oxygen
Mitochondria
Respiration
cc-by (c) Cano Franco, Isaac et al., 2014
http://creativecommons.org/licenses/by/3.0/es
Artículo
info:eu-repo/semantics/publishedVersion
Public Library of Science (PLoS)
         

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Roca Torrent, Josep; Vargas, Claudia; Cano Franco, Isaac; Selivanov, Vitaly A.; Barreiro, Esther; Maier, Dieter; Falciani, Francesco; Wagner, P. D. (Peter D.); Cascante i Serratosa, Marta; García Aymerich, Judith; Kalko, Susana; Marin-de Mas, Igor; Tegnér, Jesper; Escarrabill Sanglas, Joan; Agustí García-Navarro, Àlvar; Gomez Cabrero, David; Synergy-COPD consortium
Roca Torrent, Josep; Vargas, Claudia; Cano Franco, Isaac; Selivanov, Vitaly A.; Barreiro, Esther; Maier, Dieter; Falciani, Francesco; Wagner, P. D. (Peter D.); Cascante i Serratosa, Marta; García Aymerich, Judith; Kalko, Susana; Marin-de Mas, Igor; Tegnér, Jesper; Escarrabill Sanglas, Joan; Agustí García-Navarro, Àlvar; Gomez Cabrero, David; Synergy-COPD consortium
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Gomez Cabrero, David; Menche, Jörg; Cano, Isaac; Abugessaisa, Imad; Huertas Migueláñez , M.Mercedes , M.; Tenyi, Akos; Marin-de Mas, Igor; Kiani, Narsis A.; Marabita, Francesco; Falciani, Francesco; Burrowes, Kelly; Maier, Dieter; Wagner, P. D. (Peter D.); Selivanov, Vitaly A.; Cascante i Serratosa, Marta; Roca Torrent, Josep; Barabási, Albert László; Tegnér, Jesper